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Akeso's Bispecific Antibody Targeting Aβ and BBB-Expressed Receptor Approved for Alzheimer's Disease Clinical Trials in China
Prnewswire· 2025-11-17 02:29
Core Insights - Akeso, Inc. has received approval from the National Medical Products Administration (NMPA) to initiate clinical trials for its bispecific antibody AK152, targeting Alzheimer's Disease [1][2]. Company Overview - Akeso is a leading biopharmaceutical company founded in 2012, focusing on innovative biological medicines and has developed a comprehensive end-to-end drug development platform [10]. - The company has a robust pipeline of over 50 innovative assets across various disease areas, with 24 candidates currently in clinical trials [10]. Product Development - AK152 is the first bispecific antibody developed in China aimed at disease-modifying therapy for Alzheimer's Disease, marking a significant breakthrough in the field [2]. - The antibody targets both amyloid-beta (A) and a receptor expressed on the blood-brain barrier (BBB), enhancing brain penetration and therapeutic efficacy [4][6]. Mechanism of Action - AK152 binds to amyloid-beta plaques and selectively targets neurotoxic soluble A oligomers, while also utilizing receptor-mediated endocytosis to improve brain penetration [4][6]. - Preclinical studies indicate that AK152 significantly improves brain penetration and accelerates the clearance of A plaques compared to conventional monoclonal antibodies [5][6]. Clinical Significance - The development of AK152 addresses critical unmet clinical needs in treating Alzheimer's Disease, which has long posed therapeutic challenges globally [5]. - The promising preclinical results suggest that AK152 could become a next-generation disease-modifying therapy for Alzheimer's patients [6].
KMX INVESTOR ALERT: Robbins Geller Rudman & Dowd LLP Announces that CarMax, Inc. Investors with Substantial Losses Have Opportunity to Lead Investor Class Action Lawsuit
Prnewswire· 2025-11-16 20:40
Core Viewpoint - The CarMax class action lawsuit alleges that the company and its executives misrepresented growth prospects, leading to significant stock price declines following disappointing financial results and executive termination announcements [3][4][5]. Group 1: Class Action Details - The class action lawsuit is titled Cap v. CarMax, Inc., and it involves purchasers of CarMax securities from June 20, 2025, to November 5, 2025 [1]. - Investors have until January 2, 2026, to seek appointment as lead plaintiff in the lawsuit [1][6]. - The lawsuit claims that CarMax overstated its growth prospects, attributing earlier growth to temporary factors related to customer behavior influenced by tariff speculation [3]. Group 2: Financial Performance - On September 25, 2025, CarMax reported a 5.4% decrease in retail unit sales and a 6.3% decrease in comparable store unit sales for the second quarter of fiscal year 2026, with net earnings per diluted share dropping from $0.85 to $0.64 year-over-year [4]. - Following this report, CarMax's stock price fell approximately 20% [4]. - On November 6, 2025, CarMax announced the termination of CEO William D. Nash and projected a significant decline in used car sales for the third quarter, resulting in a further stock price drop of over 24% [5].
FLY INVESTOR ALERT: Bronstein, Gewirtz & Grossman LLC Announces that Firefly Aerospace Inc. Investors with Substantial Losses Have Opportunity to Lead Class Action Lawsuit
Prnewswire· 2025-11-16 17:00
Core Points - A class action lawsuit has been filed against Firefly Aerospace Inc. for alleged violations of federal securities laws related to its IPO and subsequent securities transactions [1][2]. Group 1: Lawsuit Details - The lawsuit seeks to recover damages for investors who purchased Firefly securities during the IPO on August 7, 2025, and within the class period ending September 29, 2025 [2]. - The Complaint alleges that the Offering Documents were negligently prepared, containing untrue statements of material fact and omitting necessary information, thus misleading investors [3]. - Specific allegations include that Firefly overstated demand for its Spacecraft Solutions, the operational readiness of its Alpha rocket program, and that these misrepresentations would likely have a material negative impact on the Company [3]. Group 2: Next Steps for Investors - Investors who suffered losses in Firefly have until January 12, 2026, to request appointment as lead plaintiff in the class action [4]. - The law firm representing the investors operates on a contingency fee basis, meaning they will only collect fees if the case is successful [5]. Group 3: Law Firm Background - Bronstein, Gewirtz & Grossman, LLC is a nationally recognized law firm specializing in securities fraud class actions and has recovered hundreds of millions of dollars for investors [6].
FLY Investor Alert: A Securities Fraud Class Action Lawsuit Has Been Filed Against Firefly Aerospace Inc. (FLY) - Contact Kessler Topaz Meltzer & Check, LLP
Prnewswire· 2025-11-16 16:17
Core Viewpoint - A securities class action lawsuit has been filed against Firefly Aerospace Inc. for allegedly making false and misleading statements regarding its business operations and growth prospects during its IPO and subsequent period [1][2]. Group 1: Lawsuit Details - The lawsuit is on behalf of investors who purchased Firefly's common stock during the IPO on August 7, 2025, and securities acquired between August 7, 2025, and September 29, 2025 [1]. - The lead plaintiff deadline for the lawsuit is set for January 12, 2026 [1][3]. Group 2: Allegations Against Defendants - The complaint alleges that Firefly overstated the demand and growth prospects for its Spacecraft Solutions offerings [2]. - It is claimed that the Alpha rocket program did not meet its operational readiness and commercial viability as represented [2]. - As a result of these issues, the statements made by the defendants regarding the company's business and prospects were materially false and misleading [2]. Group 3: Lead Plaintiff Process - Investors may seek to be appointed as a lead plaintiff representative of the class by the deadline or may choose to remain absent [3]. - The lead plaintiff is typically the investor or group of investors with the largest financial interest in the case [3]. Group 4: Law Firm Background - Kessler Topaz Meltzer & Check, LLP has a reputation for prosecuting class actions and has recovered billions for victims of corporate misconduct [4]. - The firm encourages affected investors to contact them for more information regarding the lawsuit [4].
Mondevo Group errichtet globalen Hauptsitz im Abu Dhabi Global Market
Prnewswire· 2025-11-16 16:02
Core Insights - Mondevo Group has established its global headquarters in Abu Dhabi Global Market (ADGM), leveraging Abu Dhabi's position as a leading hub for artificial intelligence, digital assets, and next-generation financial services [1][2] Strategic Considerations for Abu Dhabi - The decision to set up in ADGM is driven by its innovation-friendly regulations, advanced AI infrastructure, and global connectivity, aligning with Mondevo's long-term vision [2][4] - Abu Dhabi's commitment to digital transformation and technological development provides a solid foundation for Mondevo's operations [2][3] AI-First Government Vision - Abu Dhabi has allocated 13 billion AED as part of its Digital Strategy 2025-2027 to become the world's first fully AI-driven government, with over 200 AI solutions being implemented in public services [3] Advanced Framework for Digital Assets - ADGM has established clear regulations for digital assets, tokenization, and blockchain technologies, making it an ideal environment for Mondevo's ambitions [4] Business-Friendly Environment - The common law system, tax efficiency, and transparent oversight in ADGM create an optimal base for innovative financial service groups [5] Leadership Perspective - Hussam Otaibi, founder of Mondevo Group, emphasized Abu Dhabi's operational commitment to becoming the AI capital of the world, highlighting the emirate's creation of a necessary ecosystem for scaling their AI-native merchant banking platform [6] Building an AI-Based Ecosystem for Wealth Management and Innovation - Mondevo Group operates on three complementary pillars: Mondevo Wealth (AI-driven private wealth management), Mondevo Ventures (investments in AI-native companies), and MondeVita (luxury and lifestyle investments), supported by a technology hub in Singapore [7] Alignment with National Vision - The establishment of Mondevo Group aligns with Abu Dhabi's vision to position itself as a global hub for innovation-driven economic growth, supported by the emirate's Digital Strategy 2025-2027 [8] Company Information - Mondevo Group is an AI-native wealth and innovation ecosystem serving global family offices, operating through its three pillars and supported by a technology team in Singapore [9]
Sinopec übergibt der Universität Kairo 1.000 Bücher anlässlich der Eröffnung des Silk Road Book House - China Bookshelf
Prnewswire· 2025-11-16 07:27
Accessibility StatementSkip Navigation Bücher als Brücken: Vertiefung des chinesisch-ägyptischen Kulturaustauschs und gegenseitiges Lernen zwischen den Zivilisationen CAIRO, 16. November 2025 /PRNewswire/ -- China Petroleum & Chemical Corporation (HKG: 0386, "Sinopec") hat im Rahmen der Initiative "Silk Road Book House – China Bookshelf" 1.000 sorgfältig ausgewählte Bücher an die Universität Kairo geliefert. Die gemeinsam von Sinopec und der Universität Kairo kuratierte Sammlung umfasst die Bereiche trad ...
Sinopec fait don de 1 000 livres à l'université du Caire à l'occasion du lancement de la Silk Road Book House - China Bookshelf
Prnewswire· 2025-11-16 07:22
Accessibility StatementSkip Navigation Continue Reading Sinopec Provides 1,000 Books to Cairo University with the Launch of Silk Road Book House - China Bookshelf. La cérémonie de lancement s'est déroulée en présence de M. Lu Chunsheng, ministre conseiller à l'ambassade de Chine en Égypte, de M. Yu Yongsheng, directeur général du département de la marque du groupe Sinopec, de la professeure Naglaa Raafat, doyenne de la faculté des arts de l'université du Caire, et de plus de 260 professeurs et étudian ...
INVESTIGATION ALERT: Edelson Lechtzin LLP Announces Investigation of Coty Inc. (NYSE: COTY) and Encourages Investors with Substantial Losses or Witnesses with Relevant Information to Contact the Firm
Prnewswire· 2025-11-16 00:48
Company Overview - Coty Inc. is a global beauty company founded in 1904, specializing in fragrances, cosmetics, and skincare [3]. Allegations and Investigation - Edelson Lechtzin LLP is investigating potential violations of federal securities laws involving Coty Inc., stemming from allegations of providing misleading business information to investors [1]. - The investigation follows Coty's announcement of its full-year 2025 and fourth-quarter results on August 20, 2025, which revealed an unexpected loss and guidance that was softer than anticipated [4]. - The CFO of Coty attributed the disappointing results to several factors, including slowing beauty-market profits, value-seeking consumers, innovation fatigue, and the impacts of anti-theft and immigration policy changes [4]. - Following the earnings announcement, Coty's stock price dropped by $1.05 per share, or 21.6%, closing at $3.81 per share on August 21, 2025 [4].
U.S. Chief of Naval Operations Visits HD Hyundai Heavy Industries and Confirms World-Class Naval Shipbuilding Capabilities
Prnewswire· 2025-11-16 00:00
Core Viewpoint - The visit of Admiral Daryl Caudle, Chief of Naval Operations of the United States, to HD Hyundai Heavy Industries highlights the company's advanced shipbuilding capabilities and the potential for enhanced cooperation under the MASGA initiative aimed at strengthening U.S. naval shipbuilding [1][4][9]. Group 1: Visit and Discussions - Admiral Caudle visited HD Hyundai Heavy Industries' Ulsan shipyard on November 15, 2025, to witness the company's shipbuilding capabilities and discuss future collaboration [1][4]. - During the visit, Chairman Chung Kisun introduced HD Hyundai's advanced shipbuilding technologies and discussed ways to strengthen bilateral cooperation for improving the operational readiness of the U.S. Navy fleet [5][9]. - The visit included a tour of the commercial shipbuilding facilities and the Naval Ship Division, where advanced Aegis destroyers are constructed [5][6]. Group 2: Shipbuilding Projects - Admiral Caudle boarded the newly launched ROKS Dasan Jeong Yak-yong, the second Aegis destroyer, and received a briefing on its combat systems and operational capabilities [3][6]. - HD Hyundai is currently integrating its naval, commercial, and mid-sized shipbuilding capabilities through a merger with HD Hyundai Mipo, aiming to maximize synergy and expand exports [7]. - The company is actively expanding its presence in global defense markets, including the U.S., leveraging its experience in building advanced Aegis destroyers for foreign clients [8]. Group 3: Future Cooperation - The discussions during Admiral Caudle's visit are expected to advance technical cooperation and supply chain integration in warship construction between HD Hyundai and the U.S. Navy [9]. - Chairman Chung emphasized HD Hyundai's commitment to supporting the growth of the U.S. shipbuilding industry and enhancing the U.S. Navy's capabilities through the MASGA project [9][11]. - HD Hyundai is broadening its cooperation with the U.S. Navy, as evidenced by previous visits from U.S. Navy officials and ongoing discussions on future maritime research opportunities [11].
National Restaurant Association Statement on Removal of Tariffs on Food and Agricultural Products
Prnewswire· 2025-11-15 19:23
Core Points - President Trump signed an Executive Order to remove tariffs on certain food and agricultural products, aimed at stabilizing supply chains and reducing cost pressures for restaurants and consumers [1][4] - The National Restaurant Association supports this action, highlighting that food costs have increased nearly 40% over the past four years, and emphasizes the need for further tariff reductions to maintain affordable prices [1][4] - The removal of tariffs is seen as a step to strengthen the food supply chain, reduce costs, and support menu innovation, with calls for further actions on alcohol, supplies, and equipment essential to the hospitality industry [3][4] Industry Impact - The restaurant industry relies on a steady and affordable supply of ingredients, with many products not being able to be sourced domestically due to seasonal and climate limitations, making this tariff removal beneficial for maintaining diverse menus and reasonable prices [2] - The National Restaurant Association represents over 1 million restaurant and foodservice outlets and a workforce of 15.7 million employees, indicating the significant scale and economic impact of the industry [5] - The ongoing challenges for the industry include labor, rent, swipe fees, and utilities, highlighting the need for continued collaboration with policymakers to address these cost issues [4]