A few misplaced amino acids in the hemoglobin protein can cause a lifetime of pain, organ damage, and emergency transfusions. For 30 years, the standard of care for these cickle cell anemia patients was hydroxyura, a drug approved in 1998 that manages symptoms without correcting the underlying genetic defect. In December 2023, the FDA approved a therapy that acts as a functional cure for this disorder.Crisper Therapeutics built Casvy, the first commercially approved crisper edited medicine. The treatment ex ...

Market Dynamics - Artificial intelligence innovation costs are collapsing rapidly [1] - The inference cost to answer a user query on models like ChatGPT, Grok, or Claude is dropping by 99.99% per year [1] - Frontier development costs are reaching between $200 per month and $2,000 per month, benefiting leading AI entities such as OpenAI, Anthropic, and SpaceX [2] Investment Opportunities and Industry Trends - Businesses without a need for extreme frontier capabilities can utilize existing AI models to independently build enterprises [3] - Founders and organizations are able to leverage AI-only solutions to solve market problems and streamline general and administrative tasks that previously required extensive manual effort [4]