Core Viewpoint - The company has received clinical trial approval for its long-acting bispecific antibody QX027N, which is intended for the treatment of asthma and atopic dermatitis, marking a significant advancement in its innovative dual antibody matrix in the field of autoimmune and allergic diseases [1] Group 1 - The clinical trial approval was granted by the National Medical Products Administration, with acceptance numbers CXSL2500757 and CXSL2500758 [1] - QX027N represents an important achievement in the company's bispecific antibody research and signifies further progress in its strategic layout for respiratory and skin diseases [1] - The company aims to address the clinical needs of millions of asthma and atopic dermatitis patients globally by continuing to advance innovative therapies for more effective, safer, and more convenient treatment options [1]

Core Viewpoint - The company, Qianxin Biologics-B (02509), has received clinical trial implicit approval from the National Medical Products Administration for its self-developed long-acting bispecific antibody QX027N, aimed at treating asthma and atopic dermatitis, marking a significant step in its innovative dual antibody matrix in the field of autoimmune and allergic diseases [1] Group 1 - The candidate drug QX027N represents an important achievement in the company's bispecific antibody research and signifies further progress in its collaborative layout in respiratory and dermatological disease areas [1] - The clinical approval addresses the urgent clinical needs of millions of asthma and atopic dermatitis patients worldwide, indicating the company's commitment to advancing innovative therapies [1] - The company aims to provide more efficient, safer, and more convenient treatment options for patients through continuous development and clinical translation of innovative therapies [1]

Core Viewpoint - The company has received clinical trial approval for its long-acting bispecific antibody QX027N, which is intended for the treatment of asthma and atopic dermatitis, marking a significant advancement in its innovative dual antibody matrix in the field of autoimmune and allergic diseases [1] Group 1 - The National Medical Products Administration has granted clinical trial implicit approval for QX027N, with acceptance numbers CXSL2500757 and CXSL2500758 [1] - QX027N represents a key achievement in the company's bispecific antibody research and signifies further progress in its strategic focus on respiratory and dermatological diseases [1] - The company aims to address the clinical needs of hundreds of millions of asthma and atopic dermatitis patients globally by advancing innovative therapies for more effective, safer, and more convenient treatment options [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責， 對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全 部 或 任 何部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 承董事會命 江蘇荃信生物醫藥股份有限公司 董事會主席及執行董事 裘霽宛先生 長效雙抗QX027N獲得兩項臨床試驗默示許可 本 公 告 乃 由 江 蘇 荃 信 生 物 醫 藥 股 份 有 限 公 司（「本公司」）自 願 刊 發，以 向 股 東 及 潛 在投資者提供本公司最新的業務發展狀況。 本 公 司 董 事 會（「 董事會 」）欣 然 宣 佈， 本 公 司 自 主 研 發 的 長 效 雙 抗QX027N注 射 液 獲 得 國 家 藥 品 監 督 管 理 局 藥 品 審 評 中 心 的 臨 床 試 驗 默 示 許 可（ 受 理 號： CXSL2500757，CXSL2500758），擬 用 於 治 療 哮 喘 及 特 應 性 皮 炎。該 候 選 藥 物 的 臨 床 許可標誌著本公司在自免及過敏疾病領域的創新雙抗矩 陣 正式邁入臨床階段。 QX02 ...

Group 1: Solar and Energy Stocks - Solar stocks showed recovery with New Special Energy (01799) up 4.99%, Flat Glass (06865) up 3.25%, Xinyi Solar (00968) up 3.75%, and GCL-Poly Energy (03800) up 2.27%. The China Photovoltaic Industry Association stated that rumors about a polysilicon storage platform were false, aiming to malign the industry [1][2] - Energy storage concept stocks rose against the trend, with Longpan Technology (02465) up 17.09%, Ruipu Lanjun (00666) up 15.2%, and Zhongxin Innovation (03931) up 9.22%. Lithium hexafluorophosphate prices have surged, with some market quotes reaching 150,000 yuan/ton, doubling since mid-October [1] Group 2: Oil and Gas Stocks - Oil stocks collectively declined, with CNOOC (00883) down 3.14%, CNOOC Services (02883) down 2.98%, PetroChina (00857) down 2.09%, and Sinopec (00386) down 1.79%. OPEC's monthly report indicated a slight oversupply in the oil market by 2026, contrasting previous predictions of sustained demand [2] Group 3: Steel and Mining Stocks - Steel stocks saw a midday surge, with Maanshan Iron & Steel (00323) up 7.09%, Ansteel (00347) up 2.26%, and Chongqing Iron & Steel (01053) up 2.13%. The Simandou project in Guinea, which has the potential to become the fifth-largest mine globally, has commenced production [2] Group 4: Airline and Transportation Stocks - Southern Airlines (01055) rose over 3.9% after reporting a 2.2% year-on-year increase in revenue for the first three quarters of 2025 [2] Group 5: Biotechnology and Pharmaceuticals - Gilead Sciences (01672) increased over 5.7% as it announced the clinical development of new drugs ASC36 and ASC35 [3] - Zai Lab (02509) rose over 8.4% after announcing plans for continued related transactions for the commercialization of QX001S from 2026 to 2028 [4] Group 6: Gold Stocks - Gold stocks collectively rose, with China Gold International (02099) up 5.99%, Jihai Resources (02489) up 7.3%, and Lingbao Gold (03330) up 4.47%. Gold prices have surpassed $4,100 and are testing the $4,200 resistance level [4] Group 7: US Market Movements - Major tech stocks in the US fell, with Meta Platforms (META.US) down over 2.8%, Tesla (TSLA.US) down over 2%, and Amazon (AMZN.US) down over 1.9% [5] - Eli Lilly (LLY.US) rose 2.95%, reaching a historical high, after announcing a deal to lower GLP-1 drug prices to $245 per month, potentially opening a new market of 30 million people [5] - The US airline service sector saw gains, with United Airlines (UAL.US) up 5.29% and American Airlines (AAL.US) up 3.62%, as the government is expected to reopen soon [5] Group 8: Nuclear Energy Stocks - US nuclear energy stocks rose, with Oklo (OKLO.US) up 6.67% as the government plans to finance new nuclear power plants to meet the energy demands of AI development [6] Group 9: Company-Specific Developments - On Holding (ONON.US) surged over 17.9% after reporting Q3 net sales of 794.4 million Swiss francs, exceeding market expectations [7] - AMD (AMD.US) rose 9% as it projected a 35% annual growth rate in revenue over the next three to five years, driven by AI chip demand [7]

Group 1 - The stock of Zai Lab Limited (荃信生物-B) increased by over 10%, reaching HKD 20.92 with a trading volume of HKD 10.62 million [1] - The board of directors has proposed a new annual cap for continuing connected transactions for the fiscal years 2026 to 2028, based on the business needs following the commercialization of QX001S [1] - The profit-sharing cap is expected to rise significantly from RMB 55 million in 2026 to RMB 290 million in 2028 [1] Group 2 - Zai Lab has entered into a global exclusive collaboration and licensing agreement with Roche for its self-developed long-acting dual antibody QX031N [2] - Under the agreement, Roche will receive exclusive global rights for research, development, registration, production, and commercialization of QX031N, with Zai Lab receiving an upfront payment of USD 75 million and up to USD 995 million in milestone payments [2] - Zai Lab is recognized as a leader in the domestic innovative autoimmune drug sector, with a mature pipeline that is moving towards realization, enhancing its financial capabilities [2]

Core Viewpoint - The stock of Zai Lab Limited (荃信生物-B) has increased by over 10%, reaching HKD 20.92, following announcements regarding its business strategies and partnerships in the biopharmaceutical sector [1][2]. Group 1: Business Developments - The board of Zai Lab has proposed a new annual cap for related transactions under the QX001S framework agreement for the fiscal years 2026 to 2028, with profit-sharing limits expected to rise significantly from RMB 55 million in 2026 to RMB 290 million in 2028 [1]. - Zai Lab has entered into a global exclusive collaboration and licensing agreement with Roche for its self-developed long-acting dual antibody QX031N, which includes an upfront payment of USD 75 million and potential milestone payments up to USD 995 million, along with tiered royalties on future product sales [2]. Group 2: Market Position and Outlook - Zai Lab is recognized as a leader in the domestic self-immune innovative drug sector, with a strong foundation in this field [2]. - The company's mature pipeline is approaching a monetization phase, and its innovative pipeline is seeing successful international licensing agreements, which further supports its stable operations [2].

江蘇荃信生物醫藥股份有限公司 （ 於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司 ） （股份代號：2509） 持續關連交易： 重 續QX001S框架協議年度上限 及 建議修訂本公司之公司章程 茲提述本公司刊發的日期為2024年3月12日 的 招 股 章 程（內 容 有 關 本 公 司 與 中 美 華東訂立的QX001S框 架 協 議）及 本 公 司 日 期 為2024年9月12日 的 公 告。除 另 有 界 定者外，本公告所用詞彙與招股章程及該公告所界定者具有相同涵義。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責， 對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全 部 或 任 何部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 Qyuns Therapeutics Co., Ltd. 董事會已考慮賽樂信® （QX001S）商 業 化 後 的 業 務 需 要，並 建 議 根 據QX001S框 架 協議的條款為2026年 至2028年三個財政年度的持續關連交易重續新年度上限。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責， 對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全 部 或 任 何部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 Qyuns Therapeutics Co., Ltd. 江蘇荃信生物醫藥股份有限公司 （ 於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司 ） （股份代號：2509） 持續關連交易： 重 續QX001S框架協議年度上限 及 建議修訂本公司之公司章程 茲提述本公司刊發的日期為2024年3月12日 的 招 股 章 程（內 容 有 關 本 公 司 與 中 美 華東訂立的QX001S框 架 協 議）及 本 公 司 日 期 為2024年9月12日 的 公 告。除 另 有 界 定者外，本公告所用詞彙與招股章程及該公告所界定者具有相同涵義。 – 1 – 本公司將召開臨時股東大會供獨立股東考慮及酌情批准 重 續 新 年 度 上 限。於 本 公告日期，中美華東持有本公司已發行股本（不包括本公司持作庫存股份的股份） 的15.85%。因此 ...

Group 1 - The company, Zhenxin Biotechnology-B (02509), announced a share buyback on November 11, 2025, costing approximately HKD 998,800 for 52,200 shares [1]