Q4 AND FULL YEAR 2025 EARNINGS CALL Cautionary Note on Forward-looking Statements The statements made in, and during the course of, this presentation that are not statements of historical fact, including those related to the Company's commercial capabilities, initiatives and production, its product pipeline and associated timelines, its upcoming corporate milestones, and its growth strategy and projections, are forward looking statements within the meaning of Section 27A of the Securities Act of 1933 and Se ...

Met 2025 revenue and exceeded revised adjusted EBITDA; reaffirms 2026 revenue and sets adjusted EBITDA target Commercial Channel grew 22% and 15% for Q4 and full year, respectively Generated $11.2 million operating cash flow and $4.4 million in free cash flow for the full year FDA response for Hyalofast® PMA received in January 2026, Anika developing responses for submission BEDFORD, Mass., Feb. 26, 2026 (GLOBE NEWSWIRE) -- Anika Therapeutics, Inc. (Nasdaq: ANIK), a global leader in the osteoarthritis (“OA ...

Group 1 - Anika Therapeutics, Inc. is a global joint preservation company focused on early intervention orthopedics, with a presentation scheduled at the Canaccord Genuity 2026 Musculoskeletal Conference on March 2, 2026 [1] - The presentation will be available via live webcast and archived for 30 days, allowing investors to access the information post-event [2] - Anika specializes in minimally invasive orthopedic products, particularly in Osteoarthritis Pain Management and Regenerative Solutions, leveraging expertise in hyaluronic acid and implant solutions [3] Group 2 - Anika's global operations are headquartered outside of Boston, Massachusetts, emphasizing its strategic location for industry engagement [3] - The company actively engages with investors through one-on-one meetings during events, showcasing its commitment to investor relations [1][2]

Core Viewpoint - Anika Therapeutics, Inc. will release its fourth quarter and year-end 2025 financial results on February 26, 2026, followed by a conference call to discuss the results and business highlights [1]. Group 1: Financial Results Announcement - The financial results will be issued before the market opens on February 26, 2026 [1]. - A conference call is scheduled for 8:30 a.m. ET on the same day to discuss the results [1]. Group 2: Conference Call Access - The conference call can be accessed via a toll-free domestic number (1-800-717-1738) or an international number (1-646-307-1865) with the conference ID number 89327 [2]. - A live audio webcast and presentation materials will be available on Anika's Investor Relations website [2]. - The call will be archived and accessible shortly after its conclusion on the same website [2]. Group 3: Company Overview - Anika Therapeutics, Inc. is a global joint preservation company focused on early intervention orthopedic care [3]. - The company specializes in hyaluronic acid and implant solutions, partnering with clinicians to provide minimally invasive products [3]. - Anika targets high opportunity areas within orthopedics, including Osteoarthritis Pain Management and Regenerative Solutions, with products delivered in key care sites like ambulatory surgery centers [3]. - The company's global operations are headquartered outside of Boston, Massachusetts [3].

Core Viewpoint - Anika Therapeutics, Inc. is under investigation by Kirby McInerney LLP for potential violations of federal securities laws and other unlawful business practices related to its senior management [1]. Group 1: Company Performance - On July 30, 2025, Anika announced topline results from its clinical trial of Hyalofast, which is a resorbable hyaluronic acid scaffold for cartilage repair. The results indicated that while Hyalofast showed consistent improvements in treated patients compared to microfracture, it did not meet its pre-specified co-primary endpoints [2]. - The clinical trial's outcomes were likely affected by a higher dropout rate in the microfracture arm and missed visits during COVID, leading to missing data that complicated the statistical analysis [2]. - Following the announcement, Anika's share price fell by $3.06, or approximately 27.42%, closing at $8.10 per share on the same day [2]. Group 2: Legal Investigation - The ongoing investigation aims to determine if claims can be filed under federal securities laws, although no lawsuit has been initiated yet [3]. - Investors who purchased or acquired Anika securities and have relevant information are encouraged to contact Kirby McInerney LLP for further discussion regarding their rights or interests [3].

Compensation and Benefits - The Executive's annual base salary will be $690,000 starting from February 1, 2026[6]. - The Executive is eligible for a target annual bonus of 75% of the Base Salary, commencing with fiscal year 2026[7]. - The Executive will receive an equity award valued at $2,450,000, consisting of 50% restricted stock units and 50% stock appreciation rights[9]. - The Executive is entitled to reimbursement for reasonable expenses incurred during the Term[10]. - The Executive will have flexible, nonaccrual paid time off according to the Company's vacation policy[12]. - The Company will pay the Executive an amount equal to 18 months of the Executive's then-current Base Salary as Severance Amount, paid in equal installments over 18 months[24]. - If the Executive's employment is terminated without Cause or for Good Reason, the Company will pay the Accrued Benefit through the Date of Termination[23]. - If the Date of Termination occurs after the end of a fiscal year, the Company will pay any annual bonus that would have been earned if the Executive had remained employed[30]. - The Severance Amount will commence within 60 days after the Date of Termination, with specific conditions for payments spanning calendar years[24]. - The Company will cover the employer portion of COBRA premiums for the Executive during the continuation of health benefits[28]. - Payments under this Agreement are subject to compliance with Section 409A of the Internal Revenue Code[36]. - The Company may amend the Agreement to ensure compliance with Section 409A without additional cost to either party[37]. Employment Termination - The Executive's employment may be terminated for Cause, which includes willful misconduct or material breach of the agreement[16]. - The Company may terminate the Executive's employment without Cause at any time during the Term[17]. - The Executive may terminate his employment for Good Reason, which includes material changes in responsibilities or salary[18]. - All stock options and other stock-based awards held by the Executive will immediately accelerate and become fully exercisable upon termination related to a Change in Control[29]. - In the event of a Change in Control, the Change in Control Severance Amount will equal 2 times the sum of the Executive's Base Salary and target annual bonus for the current fiscal year[27]. Confidentiality and Intellectual Property - The Company emphasizes the importance of confidentiality regarding financial information, forecasts, and business plans, which could lead to competitive disadvantages if disclosed[40]. - The Executive is required to disclose all inventions and developments made during employment, which will be assigned to the Company, ensuring all intellectual property rights are protected[43]. - The Executive must not disclose any confidential information obtained from previous employers during their tenure with the Company[55]. Non-Competition and Non-Solicitation - The Executive agrees to noncompetition for 12 months post-employment, restricting engagement with competing businesses in specified territories[50]. - The Executive's eligibility for noncompete compensation is contingent upon compliance with the noncompetition and nonsolicitation provisions[52]. Indemnification - The Executive shall be provided with rights to indemnification and coverage under the Company's D&O insurance policy[74]. - The Company will indemnify Indemnitee for all reasonable expenses incurred in connection with any proceeding, provided Indemnitee acted in good faith[99]. - Indemnitee is entitled to indemnification for expenses if they are successful in any proceeding, with the Company covering all reasonable expenses incurred[102]. - The Company will advance expenses incurred by Indemnitee within 30 days of receiving a request, regardless of Indemnitee's ability to repay[106]. - Indemnification will not be provided for amounts already received under any insurance policy or for any claims where Indemnitee is found liable to the Company[104]. - The Company must consent to any settlement of a proceeding, and will not indemnify for amounts paid in settlements made without prior consent[111]. - A determination of Indemnitee's entitlement to indemnification will be made by disinterested directors or Independent Counsel, depending on whether a Change in Control has occurred[112]. - The Company agrees to reimburse Indemnitee for expenses incurred while cooperating with Independent Counsel or the Company in determining entitlement to indemnification[113]. - Indemnitee must submit a written request for indemnification, specifying the basis for the claim and the amounts sought[107]. - The Company will not indemnify for any claims initiated by Indemnitee against the Company unless consented to by the Board[104]. - The Company will indemnify Indemnitee for expenses incurred as a witness in any proceeding where Indemnitee is not a party[103]. - The determination of entitlement to indemnification shall be made without regard to the Indemnitee's entitlement to insurance coverage[115]. - Indemnitee is presumed to be entitled to indemnification if a request is submitted, placing the burden of proof on the Company to overcome this presumption[118]. - The Company must indemnify Indemnitee to the fullest extent permitted by law against any Enforcement Expenses incurred in connection with indemnification actions[126]. - The rights to indemnification and advancement are non-exclusive and do not limit any other rights Indemnitee may have under applicable law or agreements[129]. - The Company is required to maintain liability insurance for its directors and officers, covering Indemnitee to the maximum extent available[131]. - The Agreement will continue until ten years after Indemnitee ceases to serve as a director or one year after the final termination of any related proceeding[134]. Agreement Provisions - The Agreement constitutes the entire agreement between the parties and supersedes any prior agreements[62]. - All payments made to the Executive under this Agreement shall be net of any required tax withholdings[63]. - The Agreement shall benefit the Executive's personal representatives and continue payments to the designated beneficiary in the event of the Executive's death[64]. - If any provision of the Agreement is declared illegal or unenforceable, the remainder shall remain valid[65]. - The Agreement may only be amended in writing, signed by both the Executive and a duly authorized representative of the Company[68]. - The Agreement is governed by the laws of the Commonwealth of Massachusetts[69]. - The Company must require any successor to assume and agree to perform this Agreement[71]. - No modification or waiver of the Agreement shall be binding unless executed in writing by both parties[138]. - The Company intends for the Agreement to comply with the Indemnification exception under Section 1.409A-1(b)(10) of the Internal Revenue Code, ensuring no deferral of compensation for bona fide claims against Indemnitee[144]. - The Company and Indemnitee agree that monetary damages for breach of the Agreement may be inadequate, allowing for injunctive relief and specific performance without the necessity of showing actual damage[148]. - The Agreement may be executed in one or more counterparts, each deemed an original, but collectively constituting one Agreement[147]. - All notices under the Agreement must be in writing and can be delivered by hand, certified mail, overnight courier, or facsimile transmission[141]. - The Company and Indemnitee consent to the exclusive jurisdiction of the Delaware Court for any actions arising from the Agreement[145]. - The Company acknowledges that a bond or undertaking may be required by the Court, but waives any such requirement for Indemnitee[149]. - Indemnitee must promptly notify the Company upon being served with any legal documents related to indemnification[140]. - The Company will contribute to the amount incurred by Indemnitee if indemnification is unavailable, reflecting the relative benefits received by both parties[142]. - The Agreement is governed by the laws of the State of Delaware, without regard to its conflict of laws rules[145]. - The headings in the Agreement are for convenience only and do not affect its construction[146].

Core Viewpoint - Anika Therapeutics has announced a leadership transition, appointing Stephen Griffin as the new President and CEO, effective February 1, 2026, succeeding Cheryl R. Blanchard, who will become Executive Chair of the Board of Directors [1][5]. Leadership Transition - Stephen Griffin has been with Anika as CFO since 2024 and COO since April 2025, bringing a strong background in strategic transformation and operational excellence [2][6]. - Cheryl R. Blanchard has served as CEO for six years and will continue to support the company as Executive Chair, focusing on regulatory expertise and product development [3][4]. Strategic Focus - Griffin aims to accelerate growth, improve operational discipline and profitability, and direct resources effectively to enhance value for patients, employees, healthcare professionals, and shareholders [3][4]. - Under Blanchard's leadership, Anika has focused on hyaluronic acid innovations, achieving double-digit growth in its commercial channel and launching new products like the Integrity Implant System [3][4]. Board Changes - John B. Henneman, III has been appointed as Lead Independent Director, and the company will accept the resignation of Susan N. Vogt, effective February 1, 2026, due to board size limitations [1][4]. Financial Guidance - Anika has reaffirmed its fiscal 2025 guidance, which was previously confirmed on November 5, 2025, alongside its third-quarter financial results [4].

Group 1 - Anika Therapeutics, Inc. is under investigation by Kirby McInerney LLP for potential violations of federal securities laws or unlawful business practices by the company or its senior management [1] - On July 30, 2025, Anika announced topline results from its clinical trial of Hyalofast, which showed improvements in treated patients but did not meet pre-specified co-primary endpoints due to a higher dropout rate and missed visits during COVID [2] - Following the announcement, Anika's share price fell by $3.06, approximately 27.42%, closing at $8.10 per share on the same day [2] Group 2 - Investors who purchased or acquired Anika securities and have information regarding the investigation are encouraged to contact Kirby McInerney LLP for further discussion about their rights or interests [3] - Kirby McInerney LLP specializes in securities litigation and has achieved recoveries totaling billions of dollars for shareholders [4]

Core Viewpoint - Anika Therapeutics, Inc. is under investigation for potential violations of federal securities laws and unlawful business practices following the release of disappointing clinical trial results for its product Hyalofast [1][3]. Group 1: Investigation Details - The law firm Kirby McInerney LLP is leading the investigation into Anika Therapeutics [1]. - The investigation focuses on whether Anika and/or its senior management engaged in unlawful practices related to the company's securities [1]. Group 2: Clinical Trial Results - On July 30, 2025, Anika announced topline results from a clinical trial of Hyalofast, which is a resorbable hyaluronic acid scaffold for cartilage repair [3]. - The trial showed consistent improvements in treated patients compared to microfracture, but did not meet its pre-specified co-primary endpoints [3]. - Factors affecting the trial results included a higher dropout rate in the microfracture arm and missed visits during COVID, leading to missing data and a reduced evaluable sample size [3]. - Following the announcement, Anika's share price fell by $3.06, or approximately 27.42%, closing at $8.10 per share [3].

Revenue Performance - Revenue from the OEM Channel product family decreased by 20% for the three-month period and 19% for the nine-month period ended September 30, 2025, compared to the same periods in 2024, with a total decrease of $3.9 million and $11.0 million respectively [100]. - Revenue from the Commercial Channel product family increased by 22% for the three-month period and 13% for the nine-month period ended September 30, 2025, with international OA pain management product sales increasing by $1.5 million [101]. Profitability - Gross profit for the three- and nine-month periods ended September 30, 2025 was $15.6 million and $44.6 million, respectively, down from $19.4 million and $58.9 million in the same periods in 2024 [102]. - Gross margin decreased to 56% for the three-month period and 54% for the nine-month period ended September 30, 2025, compared to 66% for both periods in 2024 [103]. Expenses - Total research and development expenses for the three-month period ended September 30, 2025 were $5.9 million, a 17% decrease from $6.9 million in the same period in 2024 [105]. - Research and development external costs increased to $3.3 million for the three-month period ended September 30, 2025, up from $2.3 million in the same period in 2024 [106]. - Selling, general and administrative expenses decreased to $11.9 million for the three-month period ended September 30, 2025, down from $13.5 million in the same period in 2024 [107]. Losses - Loss from continuing operations increased to $3.2 million for the three-month period ended September 30, 2025, compared to a loss of $1.8 million in the same period in 2024 [108]. - Adjusted EBITDA for the three-month period ended September 30, 2025 was $865,000, a decrease of $3.7 million compared to $4.5 million in the same period in 2024 [116]. - Adjusted net loss for the nine-month period ended September 30, 2025 was $11.8 million, compared to a loss of $6.3 million in the same period in 2024 [118].