Artisan Partners, an investment management company, released its fourth-quarter 2025 investor letter for “Artisan Mid Cap Fund”.  A copy of the letter can be downloaded here. The Fund seeks to invest in companies that possess franchise characteristics, with strong earnings trajectories, and are trading at a discount to the estimated private market value. US equities ended a record year with robust fourth-quarter gains. The Fund’s Investor Class, ARTMX, delivered -0.44%, the Advisor Class, APDMX, delivered - ...

Core Viewpoint - argenx is actively engaging in the healthcare sector by participating in conferences to discuss advancements in immunology and its commitment to treating severe autoimmune diseases [1]. Company Overview - argenx is a global immunology company focused on improving the lives of individuals suffering from severe autoimmune diseases [3]. - The company collaborates with leading academic researchers through its Immunology Innovation Program (IIP) to translate immunology breakthroughs into a portfolio of novel antibody-based medicines [3]. - argenx has developed and is commercializing the first approved neonatal Fc receptor (FcRn) blocker, exploring its potential across multiple serious autoimmune diseases while advancing several earlier-stage experimental medicines [3]. Event Participation - Karen Massey, the Chief Operating Officer of argenx, will participate in a fireside chat at the TD Cowen 46 Annual Healthcare Conference on March 2 at 11:50 a.m. ET [1]. - A live webcast of the presentation will be available on the Investors section of the argenx website, with a replay accessible for approximately 30 days following the event [2].

Company Overview - argenx is a global immunology company focused on improving the lives of individuals suffering from severe autoimmune diseases [3] - The company is known for developing and commercializing the first approved neonatal Fc receptor (FcRn) blocker, with ongoing evaluations of its potential in various serious autoimmune diseases [3] Upcoming Events - argenx will host a conference call and audio webcast on February 26, 2026, at 2:30 PM CET (8:30 AM ET) to discuss its full year 2025 financial results and provide a fourth quarter business update [1] - The live call can be accessed via the Investors section of the argenx website, with a replay available for approximately one year following the presentation [2] Contact Information - Media inquiries can be directed to Ben Petok at bpetok@argenx.com [4] - Investor relations can be contacted through Alexandra Roy at aroy@argenx.com [4]

Core Insights - Halozyme Therapeutics (HALO) reported a fourth-quarter 2025 adjusted loss of 24 cents per share, significantly below the Zacks Consensus Estimate of earnings of $2.15, and down from adjusted earnings of $1.26 per share in the same quarter last year [1][6] - The decline in earnings was primarily attributed to a $2.42 per share unfavorable impact from acquired IPR&D expenses related to the Surf Bio acquisition [1] Revenue Performance - Total revenues for the fourth quarter increased by 52% year over year to $451.8 million, surpassing the Zacks Consensus Estimate of $449 million [2] - The growth in revenue was driven by increased product sales and higher royalty payments, with royalty revenues totaling $258 million, up 51% from the previous year [4][6] Product Sales and Royalties - Product sales reached $122.7 million in the fourth quarter, reflecting a 54.5% increase year over year, although it fell short of the model estimate of $123.2 million [7] - Revenues under collaborative agreements were $71.1 million, marking a 47.5% year-over-year increase [7] Financial Metrics - Adjusted EBITDA for the quarter was $21.9 million, a significant decrease from $195.8 million in the same quarter last year [8] - As of December 31, 2025, the company had cash, cash equivalents, and marketable securities totaling $145.4 million, down from $702 million as of September 30, 2025 [8] Full-Year Results and Guidance - For the full year 2025, Halozyme generated revenues of $1.39 billion, a 38% increase year over year, with adjusted earnings of $4.15 per share, down from $4.23 per share in the previous year [9] - The company expects total revenues for 2026 to be between $1.71 billion and $1.81 billion, indicating year-over-year growth of 22% to 30% [10] - Royalty revenues for 2026 are anticipated to be in the range of $1.13 billion to $1.17 billion, reflecting a year-over-year growth of 30% to 35% [10] Future Expectations - Adjusted EBITDA for 2026 is projected to be between $1.125 billion and $1.205 billion, representing a year-over-year increase of 71% to 83% [11] - Adjusted earnings per share for 2026 are expected to be in the range of $7.75 to $8.25, indicating growth of 87% to 99% year over year [11] - Management anticipates a 5% to 10% decrease in royalty revenues for the first quarter of 2026 compared to the fourth quarter of 2025 due to annual contract rate adjustments [12]

Financial Data and Key Metrics Changes - Total revenue grew 38% to $1.4 billion, with royalty revenue increasing 52% to $868 million for the full year 2025 [9][17][19] - Net income for the full year was $316.9 million, compared to $444.1 million in 2024, while adjusted EBITDA was $657.6 million, up from $632.2 million in 2024 [19][20] - GAAP diluted EPS was $2.50, down from $3.43 in 2024, while non-GAAP diluted EPS was $4.15, compared to $4.23 in 2024 [19][20] Business Line Data and Key Metrics Changes - DARZALEX Subcutaneous generated $483 million in royalty revenue, a 29% year-over-year growth, with total sales reaching $14.4 billion [10][19] - Phesgo's royalty revenue increased 51% year-over-year to $105.6 million, with total sales growing 48% to approximately $3 billion [11][19] - VYVGART and VYVGART Hytrulo saw a 444% year-over-year growth in royalty revenues to $157.2 million, with total sales reaching $4.15 billion [12][19] Market Data and Key Metrics Changes - ENHANZE-enabled products now include 10 global blockbuster opportunities, with significant approvals in multiple markets including the U.S., Japan, and China [8][16] - The subcutaneous formulations of Ocrevus, Opdivo, RYBREVANT, and Tecentriq represent a combined market opportunity of approximately $30 billion by 2028 [13][16] Company Strategy and Development Direction - The company aims to expand its ENHANZE portfolio with six new programs entering phase I in 2026, bringing the total development portfolio to 15 products [24][35] - Hypercon technology is expected to meet the demand for lower volume, auto-injector-ready therapies, with projections of approximately $1 billion in royalty revenue within five years of the first launches [26][27] - The company plans to pursue strategic acquisitions to enhance its drug delivery portfolio while maintaining financial discipline [27][28] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the long-term trajectory of the company, highlighting multiple revenue drivers and the durability of royalty revenue [23][39] - The company anticipates continued strong growth from existing products and new launches, with a focus on expanding into new therapeutic areas [24][35] Other Important Information - The company completed acquisitions of Elektrofi and Surf Bio, enhancing its drug delivery capabilities with long-duration IP [6][27] - The company expects to maintain a strong balance sheet and reduce net debt to below 1x by the end of 2026 [21][22] Q&A Session Summary Question: Regarding the mechanics of DARZALEX collaboration with J&J - Management expects to enter discussions with J&J to extend the agreement closer to its expiration in 2032, emphasizing the importance of the partnership [42][43] Question: On the ADC strategy and regulatory paths - Management indicated that the regulatory pathway for converting IV to subcutaneous delivery would likely follow traditional PK non-inferiority studies [49][50] Question: Update on Hypercon products and clinical testing - Management confirmed that two Hypercon products are on track for phase I clinical testing in 2026, with completion of clinical scale-up batches underway [63][64] Question: Expectations for new partnerships in auto-injectors - Management anticipates progress with high-volume auto-injectors and expects to see interest from both current and new partners [75][76]

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Core Viewpoint - Harmony Biosciences Holdings, Inc. (HRMY) is currently viewed as a more attractive investment compared to argenex SE (ARGX) due to its stronger earnings outlook and better valuation metrics [1][3][7] Valuation Metrics - HRMY has a forward P/E ratio of 9.48, significantly lower than ARGX's forward P/E of 29.52, indicating that HRMY may be undervalued [5] - The PEG ratio for HRMY is 0.35, while ARGX has a PEG ratio of 0.72, suggesting that HRMY offers better value relative to its expected earnings growth [5] - HRMY's P/B ratio stands at 2.61, compared to ARGX's P/B of 8.36, further highlighting HRMY's superior valuation [6] Investment Ratings - HRMY holds a Zacks Rank of 1 (Strong Buy), while ARGX has a Zacks Rank of 3 (Hold), indicating a more favorable investment outlook for HRMY [3][7] - Based on the valuation metrics and earnings outlook, HRMY is considered the superior value option at this time [7]

Core Insights - Baron Health Care Fund reported a 13.10% increase in Q4, outperforming the Russell 3000 Health Care Index's 11.92% and the Russell 3000 Index's 2.40% [1] - The fund's annual return was 10.28%, compared to 14.56% and 17.15% for the respective indexes [1] - The fund focuses on businesses with sustainable competitive advantages and strong management, particularly in the healthcare sector, which is expected to show positive momentum through 2026 [1] Company Highlights - Argenx SE (NASDAQ:ARGX) significantly contributed to the fund's performance, with a one-month return of 4.04% and a 52-week gain of 26.86% [2] - As of February 5, 2026, Argenx SE's stock closed at $820.31, with a market capitalization of $50.764 billion [2] - The company is recognized for its leading FcRn inhibitor, Vyvgart, which has exceeded sales expectations and is expected to have strong long-term growth potential [3] Market Position - Argenx SE is not among the top 30 most popular stocks among hedge funds, with 50 hedge fund portfolios holding its shares at the end of Q3, a slight decrease from 53 in the previous quarter [4] - While Argenx SE is viewed as a potential investment, there are AI stocks considered to have greater upside potential and lower downside risk [4]

Core Viewpoint - Argenx SE (NASDAQ:ARGX) is identified as one of the top growth stocks on NASDAQ for the next decade, with positive ratings and significant upside potential from analysts [1][2]. Analyst Ratings and Price Targets - H.C. Wainwright maintains a Buy rating on Argenx SE with a price target of $915, indicating an 8.93% upside from current levels [1]. - Wells Fargo has also reiterated a Buy rating, increasing its price target from $1,264 to $1,317, suggesting a potential upside of 55% from current levels [2]. Revenue Estimates - Wells Fargo has raised its revenue estimates for Argenx's product Vyvgart for the 2026-2030 period by 5%-15%, reflecting expectations of stronger performance [3]. - The consensus revenue estimate for FY 2026 is $5.6 billion, which Wells Fargo believes underestimates the company's growth potential, projecting revenues could reach $6.5 billion with single-digit quarter-over-quarter growth in Q1 and low double-digit growth from Q2 to Q4 [3]. Company Overview - Argenx SE is a commercial-stage biopharmaceutical company focused on developing therapies for autoimmune diseases, operating in multiple countries including the Netherlands, the United States, China, and Japan [4]. - The company's product lineup includes VYGART HYTRULO and VYGART, and it was founded in 2008, headquartered in Amsterdam, the Netherlands [4].