Core Insights - The partnership between argenx and Monica Seles aims to raise awareness and understanding of myasthenia gravis (MG) through the 'Go for Greater' initiative at the 2025 U.S. Open Tennis Championships [1][2] - Seles publicly shares her experience with MG to empower patients and connect them with support resources [2] - Over 120,000 people in the U.S. are living with MG, which causes various symptoms including muscle weakness and fatigue [3] Company Overview - Argenx is a global immunology company focused on improving the lives of individuals suffering from severe autoimmune diseases [4] - The company collaborates with leading academic researchers through its Immunology Innovation Program to develop novel antibody-based medicines [4] - Argenx has developed the first approved neonatal Fc receptor (FcRn) blocker and is exploring its potential in multiple serious autoimmune diseases [4]

Core Viewpoint - Baron is an asset management firm that specializes in growth equity investment solutions, emphasizing a long-term and fundamental approach to investing [1] Company Overview - Founded in 1982, Baron has established a reputation for its active growth investing strategy [1] - The firm originated as an equity research company, which remains central to its operations [1] Communication Note - The account mentioned is not managed or monitored by Baron Capital, and inquiries should be directed through official channels [1]

Financial Data and Key Metrics Changes - Total operating income for Q2 2025 was $967 million, reflecting a 97% year-over-year growth, driven by significant unmet needs in MG and CIDP [14][20] - Product net sales were $949 million, with a quarter-over-quarter growth of 19% or $158 million compared to Q1 2025 [14][15] - Gross to net increased from 12% at the end of 2024 to approximately 20% by the end of Q2 2025, with net revenue per patient remaining consistent [17][76] Business Line Data and Key Metrics Changes - Plinab achieved a year-over-year growth of 97% across all approved indications, with 15,000 patients globally treated with Vipcart [6][7] - The introduction of the prefilled syringe (PFS) has driven new patient starts, with 50% of PFS patients being new to the product [25][49] - In the U.S., product net sales reached $802 million, with 18% quarter-over-quarter growth driven by strong performance in gMG and CIDP [15][16] Market Data and Key Metrics Changes - The contribution of non-U.S. markets now represents over 15% of global product net sales, with growth seen across all regions except for supply to China [15][16] - The U.S. market specifically saw strong growth across all three presentations of the product, indicating a robust demand [16][17] Company Strategy and Development Direction - The company is focused on long-term value creation through its Vision 2030 roadmap, aiming to expand its pipeline and market reach [6][8] - There is a commitment to innovation, with multiple registrational trials initiated in large market opportunities and a robust late-stage pipeline [6][8] - The company is expanding its immunology innovation platform, with four new molecules in Phase I studies targeting high unmet needs [12][13] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth potential within MG and CIDP, emphasizing the transformative impact of their treatments [31][32] - The company anticipates data from six Phase III and six Phase II trials over the next eighteen months, which could unlock new patient populations [32][33] - Management acknowledged the competitive landscape but believes their innovative approach positions them well for continued leadership [58][59] Other Important Information - The company has a strong cash position of $3.9 billion, up from $3.4 billion at the beginning of the year, driven by operating cash flow [20][88] - Total operating expenses for Q2 were $766 million, reflecting a disciplined investment in innovation [18][19] Q&A Session Summary Question: How have your cycles per year in MG evolved? - Management confirmed that they continue to guide for five cycles per year on average for an MG patient, with high utilization and adherence expected due to the convenience of PFS [38][39] Question: Can you provide a breakdown of the PFS switches between Hytrula and IV? - Management indicated that 50% of PFS patients are new to Vivgut, with the strategy focused on market expansion rather than just switching existing patients [44][45] Question: How much of the gMG patient adds were due to the prefilled syringe? - Management noted that the prefilled syringe significantly contributed to the strong quarter in MG, expanding the prescriber base and allowing for earlier lines of treatment [49][50] Question: What are your thoughts on increasing competition? - Management acknowledged the competitive dynamics but emphasized their commitment to raising treatment expectations and maintaining leadership in the market [58][59] Question: Can you comment on the CIDP launch and patient dynamics? - Management reported strong growth in CIDP, with 85-90% of patients coming from IVIG switches, indicating a long growth trajectory ahead [69][72] Question: What is the outlook for gross margin? - Management expects gross margin to remain around 11%, with decreasing costs offset by increasing royalties [67][68]

Financial Data and Key Metrics Changes - Total operating income for Q2 2025 was $967 million, reflecting a 97% year-over-year growth, driven by significant unmet needs in MG and CIDP [13][14] - Product net sales were $949 million, with a quarter-over-quarter growth of 19% or $158 million compared to Q1 2025 [13][14] - The gross to net ratio increased from 12% in 2024 to approximately 20% by the end of Q2 2025 [16][75] - The company reported a profit after tax of $245 million for the quarter, with a year-to-date profit of $415 million [20] Business Line Data and Key Metrics Changes - Plinab achieved a remarkable year-over-year growth of 97% across all approved indications [4] - The company is treating 15,000 patients globally with Vipcart, including 2,500 CIDP patients just one year post-launch [5] - The introduction of the prefilled syringe (PFS) has driven new patient starts and prescriber demand, with 50% of PFS patients being new to the product [24] Market Data and Key Metrics Changes - In the U.S., product net sales reached $802 million, with an 18% quarter-over-quarter growth [14][15] - The contribution from non-U.S. markets now represents over 15% of global product net sales, indicating successful expansion [14] - The company is seeing strong growth in Japan and Germany, with both markets off to a fast start following recent launches [61] Company Strategy and Development Direction - The company’s Vision 2030 roadmap aims for long-term value creation, with a focus on expanding labeled indications and advancing a robust late-stage pipeline [4] - The strategy includes a commitment to innovation, with multiple registrational trials initiated in large market opportunities [4][6] - The company is expanding its immunology innovation platform, with four new molecules in Phase I studies targeting high unmet needs [11] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth potential within MG and CIDP, emphasizing the transformative impact of their treatments [30] - The company anticipates data from six Phase III and six Phase II trials over the next eighteen months, which could unlock new patient populations [31] - Management acknowledged the competitive landscape but remains committed to leading through innovation and maintaining high treatment standards [56] Other Important Information - The company has a strong cash position of $3.9 billion, up from $3.4 billion at the beginning of the year, primarily driven by operating cash flow [20][88] - The effective tax rate for the year to date is reported at 15% [19] Q&A Session Summary Question: How have your cycles per year in MG evolved? - Management confirmed that net revenue per patient remains consistent despite a higher gross to net ratio, with no price increases in 2025 [36][37] Question: Can you provide a breakdown of the PFS switches between Hytrula and IV? - Management indicated that Hytrulo is driving the majority of growth, with 50% of PFS patients being new to the product [42] Question: How much of the gMG patient adds were due to the prefilled syringe? - Management noted that the prefilled syringe significantly contributed to patient growth, with a strong prescriber base established [47] Question: What are your thoughts on increasing competition? - Management acknowledged the competitive dynamics but emphasized their commitment to innovation and maintaining leadership in the market [56] Question: Can you comment on the CIDP launch and patient dynamics? - Management reported strong growth in CIDP, primarily from IVIG switches, and noted that they are still early in the launch curve [68][70] Question: What is the outlook for gross margin? - Management expects gross margin to remain around 11%, with offsetting factors affecting cost of sales [66] Question: Can you provide an update on the FDA spares update from June? - Management stated that they are monitoring the situation and have not observed a significant change in the benefit-risk ratio [98][100]

Financial Performance - Product net sales for Q2 2025 reached $949 million, demonstrating a 97% growth compared to Q2 2024[13, 14, 15] - US product net sales in Q2 2025 were $802 million, a 97% increase from $407 million in Q2 2024[15] - Japan's product net sales grew significantly to $52 million in Q2 2025, a 138% increase compared to $20 million in Q2 2024[15] - Rest of World (RoW) product net sales increased to $83 million in Q2 2025, a 119% increase from $37 million in Q2 2024[15] - Total operating income for Q2 2025 was $967 million, compared to $489 million in Q2 2024[18] - The company ended Q2 2025 with $3.9 billion in cash, including $2.1 billion in cash and cash equivalents and $1.8 billion in current financial assets[19, 33] Strategic Goals and Pipeline - The company aims to reach 50,000 patients globally across 10 labeled indications by 2030 as part of its Vision 2030 strategy[4, 8] - The company is advancing three new molecules into Phase 1 clinical trials[8] - The company has approximately 15,000 patients treated globally[8] - The company is focused on expanding the addressable market for MG (myasthenia gravis) to up to 60,000 patients by 2030[4, 25, 26]

2025 Half-Year Financial Report Table of Contents | Management report | 2 | | --- | --- | | 1 Main events in the first six months of 2025 | 2 | | 2 Financial highlights | 4 | | 3 Risk factors | 5 | | 4 Forward-looking statements | 5 | | 5 Statement of the board of directors | 6 | | Unaudited condensed consolidated interim financial statements | 7 | | Unaudited condensed consolidated interim statements of financial position | 7 | | Unaudited condensed consolidated interim statements of profit or loss | 9 | | ...

$949 million in second quarter global product net sales VYVGART SC launch in CIDP progresses with more than 2,500 patients on treatment globally July 31, 2025 7:00 AM CET Amsterdam, the Netherlands – argenx SE (Euronext & Nasdaq: ARGX), a global immunology company committed to improving the lives of people suffering from severe autoimmune diseases, today announced its half year 2025 results and provided a second quarter business update. "We continue to make meaningful progress towards our Vision 2030, advan ...

Company Overview - argenx is a global immunology company focused on improving the lives of individuals suffering from severe autoimmune diseases [3] - The company is known for developing and commercializing the first approved neonatal Fc receptor (FcRn) blocker, with ongoing evaluations for its potential in various serious autoimmune diseases [3] Upcoming Events - argenx will host a conference call and audio webcast on July 31, 2025, at 2:30 p.m. CET (8:30 a.m. ET) to discuss its half-year 2025 financial results and provide a second-quarter business update [1] - The live call can be accessed via the Investors section of the argenx website, with a replay available for approximately one year [2] Contact Information - Media inquiries can be directed to Ben Petok at bpetok@argenx.com [4] - Investor relations can be contacted through Alexandra Roy at aroy@argenx.com [4]

Core Viewpoint - Pomerantz LLP is investigating claims of potential securities fraud or unlawful business practices involving argenx SE and its officers or directors [1] Group 1: Regulatory Concerns - On June 30, 2025, the FDA issued an alert regarding argenx's Vyvgart Hytrulo product, indicating a potential risk of severe worsening of chronic inflammatory demyelinating polyradiculoneuropathy [3] - Following the FDA alert, argenx's American Depositary Share (ADS) price decreased by $8.92, or 1.59%, closing at $551.22 per ADS on the same day [3] Group 2: Legal Investigation - Pomerantz LLP is actively seeking investors of argenx to discuss potential claims related to the investigation [1] - The firm is recognized for its expertise in corporate, securities, and antitrust class litigation, having a long history of fighting for victims of securities fraud and corporate misconduct [4]

Core Viewpoint - Morgan Stanley's strategy team highlights 15 stocks with short-term catalytic potential, indicating that S&P 500 index earnings growth in Q2 may exceed expectations [1] Earnings Expectations - The market anticipates a 5% year-over-year increase in S&P 500 Q2 earnings per share and over 4% revenue growth, but actual growth may be stronger [1] - The seven major tech companies are expected to see a 14% increase in net profit, while the remaining 493 constituents may experience a 3% decline [1] - Despite analysts lowering earnings expectations from April to May, the earnings revision has rebounded from -25% to approximately 1%, suggesting Q2 earnings will likely exceed expectations, aligning with the historical average of 4%-5% [1] Recommended Stocks - **argenx SE (ARGX.US)**: undervalued R&D pipeline, target price $700 [2] - **Atlassian (TEAM.US)**: continuous revenue growth potential over 20% and expected margin expansion, target price $320 [3] - **Chewy (CHWY.US)**: benefits from marketing and product optimization, expected revenue to maintain or exceed Q1 levels, target price $50 [4] - **CVS Health (CVS.US)**: advantages from competitor store closures and growth in pharmacy benefit management, target price $80 [4] - **DraftKings (DKNG.US)**: potential earnings inflection point in Q2, with actual licensing rates offsetting tax and regulatory pressures, target price $52 [4] - **Eaton Corporation (ETN.US)**: benefits from improved profit margins in U.S. electrical business, target price $375 [5] - **Eli Lilly (LLY.US)**: core products Mounjaro and Zepbound expected to contribute $8.2 billion in revenue, exceeding expectations may lead to 2025 guidance upgrades, target price $1,135 [5] - **F5 (FFIV.US)**: positive outlook due to demand growth in cloud and load balancing products, target price $305 [6] - **NVIDIA (NVDA.US)**: strong end-user demand and accelerated shipments of rack-level products supporting supply-side growth, target price $170 [7] - **Omada Health (OMDA.US)**: operational leverage through technology empowerment and multi-disease sales, target price $25 [8] - **Southwest Airlines (LUV.US)**: potential stock rebound if internal guidance is met and baggage fee impacts are confirmed as limited, target price $38 [9] - **Valley National Bank (VLY.US)**: expected net interest income growth of 3% quarter-over-quarter, target price $11 [10] - **Western Digital (WDC.US)**: undervalued gross margin expansion prospects, target price $85 [11] Cautious Outlook - **National Storage Affiliates Trust (NSA.US)**: cautious due to expected funds from operations (FFO) per share being below market and company guidance, target price $30 [12] - **Teradyne (TER.US)**: revenue and earnings per share forecasts for FY2026 are 7% and 14% below Wall Street expectations, target price $74 [13] Summary - Overall, Morgan Stanley's recommendations combine company fundamentals, industry trends, and market sentiment, providing diversified options for investors [14]