Core Insights - Arvinas, Inc. announced new preclinical combination data for ARV-393, which will be presented at the AACR Annual meeting, highlighting its potential to be combined with standard lymphoma treatments [1][2] Group 1: Product Information - ARV-393 is an investigational PROteolysis TArgeting Chimera (PROTAC) designed to degrade B-cell lymphoma 6 protein (BCL6), a key driver of B-cell lymphomas [2][4] - The degradation of BCL6 through PROTAC technology aims to address the traditionally undruggable nature of this protein, which plays a significant role in B cell tolerance and proliferation [4] Group 2: Presentation Details - The presentation of ARV-393 will take place on April 28, 2025, at the AACR Annual meeting, with the poster titled "ARV-393, a PROteolysis TArgeting Chimera (PROTAC) BCL6 Degrader, Combined With Biologics or Small-Molecule Inhibitors Induces Tumor Regressions in Diffuse Large B-Cell Lymphoma Models" [3] - The session will focus on experimental and molecular therapeutics, specifically under the title "Degraders and Glues 2" [3] Group 3: Company Overview - Arvinas is a clinical-stage biotechnology company focused on developing therapies that utilize the body's natural protein disposal system to selectively degrade disease-causing proteins [5] - The company is advancing multiple investigational drugs, including vepdegestrant for ER+/HER2- breast cancer, ARV-393 for non-Hodgkin lymphoma, and ARV-102 for neurodegenerative disorders [5]

Arvinas, Inc. (ARVN) has been on a downward spiral lately with significant selling pressure. After declining 25.4% over the past four weeks, the stock looks well positioned for a trend reversal as it is now in oversold territory and there is strong agreement among Wall Street analysts that the company will report better earnings than they predicted earlier.How to Determine if a Stock is OversoldWe use Relative Strength Index (RSI), one of the most commonly used technical indicators, for spotting whether a s ...

Arvinas, Inc. ARVN unveiled first-in-human data on Friday for its experimental Parkinson’s disease treatment, ARV-102.Results from the randomized, double-blind, placebo-controlled single ascending dose (SAD) cohort of the Phase 1 healthy volunteer trial and initial results from the multiple ascending dose (MAD) cohort were shared in a presentation at the 2025 International Conference on Alzheimer’s and Parkinson’s Diseases.The Phase 1 trial included SAD cohorts from 10 mg to 200 mg and MAD cohorts of 10 mg ...

Core Insights - Arvinas, Inc. presented data from the first-in-human clinical trial of ARV-102, demonstrating its potential in reducing LRRK2 protein associated with neurodegenerative diseases like Parkinson's disease and progressive supranuclear palsy [1][3][7] Group 1: Clinical Trial Findings - ARV-102 was well tolerated and showed substantial LRRK2 reduction in both central and peripheral systems, indicating effective protein degradation [1][5] - The Phase 1 trial included a single ascending dose (SAD) cohort with doses from 10 mg to 200 mg and a multiple ascending dose (MAD) cohort with doses from 10 mg to 80 mg [2][3] - At doses of 60 mg or higher, ARV-102 achieved over 50% LRRK2 reduction in cerebrospinal fluid (CSF) and over 90% reduction in peripheral blood mononuclear cells (PBMCs) [5][9] Group 2: Safety and Tolerability - No serious adverse events were reported, and the drug was generally safe and well tolerated among healthy volunteers [4][5] - Common treatment-related adverse events included headache (17.1%) and fatigue (8.6%), with procedural pain from lumbar puncture reported in 28.6% of treated individuals [9] Group 3: Pharmacokinetics and Pharmacodynamics - ARV-102 demonstrated dose-dependent increases in exposure in both plasma and CSF, with a median terminal plasma half-life of 73 hours [9] - The drug's pharmacodynamic effects included significant reductions in phospho-Rab10T73 and bis(monoacylglycerol)phosphate (BMP) in urine, indicating engagement with downstream LRRK2 pathways [5][9] Group 4: Future Directions - Arvinas plans to continue the clinical program for ARV-102, with ongoing trials in patients with Parkinson's disease and expectations to present initial data in 2025 [7][10]

Core Insights - Arvinas, Inc. is set to present data from its first-in-human study of ARV-102, a drug targeting LRRK2, at the International Conference on Alzheimer's and Parkinson's Diseases in April 2025 [1][3] - ARV-102 is designed as a PROTAC to degrade LRRK2, which is linked to Parkinson's disease and progressive supranuclear palsy [2][4] - The presentation will focus on the safety, pharmacokinetics, and pharmacodynamics of ARV-102 in healthy males [3] Company Overview - Arvinas is a clinical-stage biotechnology company focused on developing therapies for serious diseases using its PROTAC platform [5] - The company is advancing multiple investigational drugs, including vepdegestrant for breast cancer, ARV-393 for non-Hodgkin lymphoma, and ARV-102 for neurodegenerative disorders [5] - Arvinas is headquartered in New Haven, Connecticut, and aims to improve patient outcomes through innovative protein degradation therapies [5]

NEW HAVEN, Conn., March 27, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical- stage biotechnology company working to develop a new class of drugs based on targeted protein degradation, today announced that data from the first-in-human study evaluating single-ascending and multiple-ascending doses in healthy volunteers of ARV-102 will be presented at the International Conference on Alzheimer's and Parkinson's Diseases (AD/PD™), April 1-5, 2025 in Vienna, Austria. ARV-102 is Arvinas' investig ...

Core Viewpoint - Arvinas, Inc. (ARVN) has experienced significant selling pressure, resulting in a 54.9% decline in stock price over the past four weeks, but analysts anticipate better earnings than previously predicted, indicating a potential turnaround for the company [1]. Group 1: Stock Performance and Technical Indicators - The stock is currently in oversold territory, with a Relative Strength Index (RSI) reading of 23.18, suggesting that the heavy selling may be exhausting itself and a price reversal could be imminent [5][6]. - A stock is generally considered oversold when its RSI falls below 30, indicating a potential entry opportunity for investors [2][3]. Group 2: Earnings Estimates and Analyst Sentiment - Over the last 30 days, the consensus earnings per share (EPS) estimate for ARVN has increased by 1.2%, reflecting a strong agreement among analysts to raise earnings estimates for the current year [6]. - ARVN holds a Zacks Rank 2 (Buy), placing it in the top 20% of over 4,000 ranked stocks based on earnings estimate revisions and EPS surprises, further supporting the potential for a turnaround [7].

Arvinas, Inc. (ARVN) has been beaten down lately with too much selling pressure. While the stock has lost 54% over the past four weeks, there is light at the end of the tunnel as it is now in oversold territory and Wall Street analysts expect the company to report better earnings than they predicted earlier.Guide to Identifying Oversold StocksWe use Relative Strength Index (RSI), one of the most commonly used technical indicators, for spotting whether a stock is oversold. This is a momentum oscillator that ...

Company Overview - Arvinas, Inc. (ARVN) shares increased by 8.8% to close at $9.03, following a trading session with significantly higher volume than usual, despite a 53.1% loss over the past four weeks [1] - The stock's recovery came after mixed results from a late-stage breast cancer study of vepdegestrant, which is in phase III VERITAC-2 study for advanced or metastatic breast cancer [2] Financial Performance - The company is projected to report a quarterly loss of $0.85 per share, reflecting a year-over-year increase of 12.4%, with expected revenues of $58.14 million, marking a 129.8% increase from the previous year [3] - The consensus EPS estimate for the upcoming quarter has been revised 26.9% higher in the last 30 days, indicating a positive trend that may lead to price appreciation [4] Industry Context - Arvinas is part of the Zacks Medical - Biomedical and Genetics industry, where another company, Certara, Inc. (CERT), saw a 1% increase to $11.01 but has a -21.4% return over the past month [4] - Certara's consensus EPS estimate has decreased by 23.8% to $0.10, showing no change from the previous year, and it currently holds a Zacks Rank of 3 (Hold) [5]

Core Insights - Arvinas, Inc. and Pfizer Inc. announced topline results from the Phase 3 VERITAC-2 trial for vepdegestrant in advanced or metastatic breast cancer patients [1][2] - The trial focused on estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+/HER2-) patients who had disease progression after prior treatments [2] Trial Results - The trial met its primary endpoint in the estrogen receptor 1-mutant (ESR1m) population, showing a statistically significant improvement in progression-free survival (PFS) compared to fulvestrant [3] - The results surpassed the pre-specified target hazard ratio of 0.60 in the ESR1m population [4] - No statistical significance was found in PFS improvement in the intent-to-treat (ITT) population, and overall survival data was not mature at the time of analysis [4] Future Plans and Designations - The trial will continue to evaluate overall survival as a key secondary endpoint [5] - Vepdegestrant was generally well tolerated during the trial [5] - Detailed results will be presented at a medical meeting later this year, and the FDA granted Fast Track designation for vepdegestrant for monotherapy in eligible patients [5] Market Reaction - Following the trial results, ARVN stock experienced a decline of 52.4%, trading at $8.35 [6]