NEW HAVEN, Conn., Oct. 01, 2025 (GLOBE NEWSWIRE) -- Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, today announced that two presentations, including one e-poster session and one oral platform presentation, featuring clinical data for ARV-102, an investigational oral PROTAC (PROteolysis TArgeting Chimera) degrader of leucine-rich repeat kinase 2 (LRRK2), will be presented at the 2025 International Congress of Parkinson ...

Core Viewpoint - Pfizer has not abandoned vepdegestrant but has deprioritized it, seeking new partners for the project with Arvinas, reflecting the challenges in the innovative drug industry [1][2][4] Group 1: Clinical Trial Results - The VERITAC-2 trial results showed that vepdegestrant achieved one of its dual primary endpoints in ESR1 mutant patients but failed to demonstrate significant improvement in progression-free survival (PFS) in the intent-to-treat population [2][3] - The trial's outcome indicates that vepdegestrant could not meet its core objective of covering the entire patient population, missing out on a significant market opportunity [2][3] Group 2: Market Position and Competition - Vepdegestrant is likely to struggle in a highly competitive market, as it has not differentiated itself from other second-generation SERDs, with Menarini's elacestrant showing superior clinical benefits [3][4] - The decision to seek new partners suggests that both Pfizer and Arvinas are acknowledging the limited competitive edge of vepdegestrant in the current landscape [4][5] Group 3: Company Performance and Market Sentiment - Arvinas has seen its market value plummet from a peak of $8 billion to approximately $552 million, illustrating the volatility and risks associated with innovative drug development [6] - The initial excitement surrounding vepdegestrant's early clinical data has not translated into sustained market success, highlighting the unpredictability of clinical trials [6][7] Group 4: Industry Insights - The situation with vepdegestrant serves as a cautionary tale for the innovative drug sector, emphasizing the gap between early expectations and later clinical realities [1][6] - The broader innovative drug industry is characterized by a pattern of high expectations followed by significant challenges, necessitating a cautious yet optimistic approach [7]

Market Overview - US stock market indices, including the Dow Jones, Nasdaq, S&P 500, and Russell 2000, reached both intraday and closing historical highs on Thursday, driven by signals from the Federal Reserve indicating an upcoming interest rate cut cycle [1][3] - The Dow Jones increased by 124.10 points (0.27%) to 46,142.42, the Nasdaq rose by 209.40 points (0.94%) to 22,470.73, the S&P 500 gained 31.61 points (0.48%) to 6,631.96, and the Russell 2000 surged by 59.317 points (2.46%) to 2,466.662 [3] Economic Indicators - The Federal Reserve is expected to lower the benchmark interest rate by 25 basis points, with two additional cuts anticipated this year, boosting investor sentiment regarding economic growth [3][4] - Initial jobless claims in the US decreased by 33,000 to 231,000, marking the largest drop in nearly four years, aligning with low layoff levels in the economy [5] Company Highlights - Intel's stock surged approximately 26% following Nvidia's announcement of a $5 billion investment to co-develop data center and personal computer chips, which also led to a more than 3% increase in Nvidia's stock [3][6] - Palantir secured a $750 million contract to expand its presence in the UK market [6] - Tesla received an order for 10,000 units of its Optimus 3+ humanoid robots [6] - TSMC's stock rose amid reports that Apple has secured over half of the 2nm production capacity for next year [6] Sector Performance - Small-cap companies, represented by the Russell 2000, are expected to benefit more from low interest rates due to their reliance on external funding for operations and growth [3] - Semiconductor stocks experienced a rally, driven by Intel's performance and Nvidia's investment announcement [6] - Quantum computing stocks saw a broad increase, continuing the upward trend from the previous day [6]

1. 9月18日(周四)美股盘前，美股三大股指期货齐涨。截至发稿，道指期货涨0.65%，标普500指数期货涨0.81%，纳指期货涨 1.09%。 2. 截至发稿，德国DAX指数涨1.35%，英国富时100指数涨0.29%，法国CAC40指数涨1.23%，欧洲斯托克50指数涨1.55%。 3. 截至发稿，WTI原油涨0.34%，报64.27美元/桶。布伦特原油涨0.28%，报68.14美元/桶。 | 틀 WTI原油 | 2025年10月 | 64.27 | 64.28 | 63.45 | +0.22 | +0.34% | | --- | --- | --- | --- | --- | --- | --- | | 器 伦敦布伦特原油 | 2025年11月 | 68.14 | 68.15 | 67.34 | +0.19 | +0.28% | 市场消息 美联储降息东风至！小盘股重回市场焦点。在美股今年创纪录式大幅上涨的大部分时间里，小盘股似乎处于观望状态。如今， 在美联储降息预期持续升温的大举推动之下，市场"动物精神"全面回归，小盘股终于在近期短暂地加入了这场投资盛宴，并几 乎终结了自大流行以来持续跑输标普500指数 ...

盘前市场动向 1. 9月18日(周四)美股盘前，美股三大股指期货齐涨。截至发稿，道指期货涨0.65%，标普500指数期货涨0.81%，纳指期货涨 1.09%。 | = US 30 | 46,319.60 | 46,366.60 | 46,025.10 | +301.30 | +0.65% | | --- | --- | --- | --- | --- | --- | | US 500 | 6,654.10 | 6,659.70 | 6,604.40 | +53.70 | +0.81% | | 트 US Tech 100 | 24,488.30 | 24,505.60 | 24.245.40 | +264.60 | +1.09% | 2. 截至发稿，德国DAX指数涨1.35%，英国富时100指数涨0.29%，法国CAC40指数涨1.23%，欧洲斯托克50指数涨1.55%。 | 德国DAX30 | 23,661.89 | 23,690.39 | 23,483.89 | +314.94 | +1.35% | | --- | --- | --- | --- | --- | --- | | 器 英国富时100 | 9, ...

Group 1 - Arvinas and Pfizer have decided to sublicense the commercialization rights of the innovative drug vepdegestrant, which is an investigational estrogen receptor degrader for breast cancer [1] - The FDA approval application for vepdegestrant was submitted in June [1] - Following significant changes in the vepdegestrant project, Arvinas plans to lay off 15% of its workforce to seek greater strategic business development opportunities and identify more efficiency improvement areas [1] Group 2 - Arvinas' pre-market stock price increased by 3.81% to $7.90, while Pfizer's pre-market stock price rose by 0.75% [1] - As of the last trading session, Arvinas closed at $7.61 with a market capitalization of $559 million [1] - The stock has a 52-week high of $29.61 and a low of $5.90, indicating significant volatility [1]

Core Viewpoint - Arvinas and Pfizer are collaborating to out-license the commercialization rights of vepdegestrant to a third party, aiming to maximize its commercial potential for treating advanced or metastatic breast cancer [2][3] Company Actions - The company plans to implement additional cost optimization measures expected to achieve total annual savings of over $100 million compared to FY 2024 [1][7] - A stock repurchase program has been authorized for up to $100 million, reflecting the company's confidence in its long-term growth prospects [1][8][10] - The company reaffirms its cash runway guidance through the second half of 2028, indicating sufficient funds to support ongoing clinical programs [1][11] Product Development - Vepdegestrant is under FDA review as a monotherapy for ER+/HER2- advanced or metastatic breast cancer, with a PDUFA action date set for June 5, 2026 [3][14] - The drug is being developed as a potential best-in-class therapeutic option for patients with ESR1 mutations [3][12] Strategic Review - Following the decision to out-license vepdegestrant, Arvinas conducted a strategic review of its business, reaffirming the potential of its pipeline of PROTAC degraders [4][5] - The company has three investigational PROTAC degraders currently in Phase 1 trials targeting various cancers and neurodegenerative diseases [4][15] Workforce and Cost Management - The company will reduce its workforce by an additional 15% to streamline operations, particularly in roles related to vepdegestrant commercialization [6] - Additional measures will be taken to limit expenditures on the vepdegestrant program while preparing for commercialization [5][6]

Core Insights - Pfizer has strengthened its R&D pipeline through mergers and acquisitions (M&A) and successful clinical trials over the past decade [1] - The company expects to have eight or more blockbuster oncology medicines in its portfolio by 2030 [4][10] Oncology Pipeline - Pfizer has advanced its oncology pipeline with several candidates in late-stage development, including vepdegestrant, atirmociclib, and sigvotatug vedotin [2][10] - Sasanlimab is under review for high-risk non-muscle invasive bladder cancer, and Pfizer has exclusive rights to develop SSGJ-707, a dual PD-1 and VEGF inhibitor [3] Recent Approvals and Growth - In 2023, Pfizer achieved a record with nine new medicine/vaccine approvals, and in 2024, it gained approval for a gene therapy for hemophilia [5][10] - New products are contributing to top-line growth, and the company maintains a robust R&D pipeline with potential blockbuster drugs [6] Competitive Landscape - Major competitors in the oncology space include AstraZeneca, Merck, Johnson & Johnson, and Bristol-Myers, each with significant oncology sales contributing to their overall revenues [8][9][11] Financial Performance - Pfizer's stock has declined 1.2% in 2023, while the industry has seen a 1.5% increase [12] - The company's shares are trading at a price/earnings ratio of 8.01, lower than the industry average of 14.75 and its own 5-year mean of 10.71 [13] Earnings Estimates - The Zacks Consensus Estimate for 2025 earnings has increased from $3.05 to $3.13 per share, while the estimate for 2026 remains stable at $3.09 [14]

Investment Rating - The report maintains a "Buy" rating for Galaxy Entertainment, highlighting the resilience of the gaming industry and the long-term growth potential of the company [6]. Core Insights - Galaxy Entertainment achieved a net revenue of HKD 12 billion in Q2 2025, representing an 8% quarter-on-quarter increase and a 10% year-on-year increase. The adjusted EBITDA was HKD 3.2 billion, with a 7% quarter-on-quarter increase but a 1% year-on-year decline. Key revenue metrics have recovered to 82%, 130%, 138%, and 31% of 2019 levels for total gross revenue, mass market revenue, slot machine revenue, and VIP turnover, respectively [6][8]. - The company has a net cash position of HKD 30.3 billion as of June 30, 2025, and announced an interim dividend of HKD 0.70 per share, with a payout ratio of 58%, up from 50% in 2024 [6][8]. Summary by Sections 1. Overseas Social Services - Galaxy Entertainment's Q2 2025 performance shows a recovery in various revenue streams, with EBITDA returning to 79% of 2019 levels. The Capella Hotel is in trial operation, with full opening expected soon. The Macau Galaxy Phase IV project is progressing, with completion expected in 2027 [6][8]. 2. Overseas Pharmaceuticals - The 2025 medical insurance directory and commercial insurance innovative drug directory preliminary review has been published, with 534 out of 718 submissions passing the initial review. The new directory includes several CAR-T products and other innovative drugs [10][12]. 3. Domestic Pharmaceutical Companies - Crystal Holdings expects a revenue of at least HKD 500 million in H1 2025, a year-on-year increase of approximately 387%. In contrast, Jinxin Reproductive expects a net loss of no more than HKD 1.09 billion due to asset impairments [11][12]. 4. Overseas Pharmaceutical Company Updates - Insmed's DPP-1 inhibitor, BRINSUPRI, has received FDA approval for treating non-cystic fibrosis bronchiectasis. Novartis's BAFF-R monoclonal antibody has met primary endpoints in two Phase III studies for treating active Sjögren's syndrome [13][14]. 5. Investment Recommendations - The report suggests focusing on innovative drugs and pharmaceutical companies with strong clinical pipelines, including companies like BeiGene, Innovent Biologics, and others [15]. 6. Market Performance - The Hang Seng Healthcare Index rose by 3.50%, outperforming the Hang Seng Index by 1.75 percentage points, indicating a positive market sentiment towards healthcare stocks [8].

Core Viewpoint - The FDA has accepted the New Drug Application (NDA) for vepdegestrant, a novel treatment for advanced or metastatic breast cancer, with a PDUFA action date set for June 5, 2026 [1][5]. Company Overview - Arvinas, Inc. is a clinical-stage biotechnology company focused on developing therapies for life-threatening diseases using its PROTAC protein degrader platform [8]. - The company is collaborating with Pfizer for the co-development and commercialization of vepdegestrant, sharing development costs and profits [4]. Product Details - Vepdegestrant is an investigational oral PROTAC estrogen receptor degrader aimed at treating ER+/HER2- advanced or metastatic breast cancer with ESR1 mutations [3][5]. - The drug has shown statistically significant improvement in median progression-free survival compared to fulvestrant in the Phase 3 VERITAC-2 clinical trial [1][2]. Clinical Trial Information - The VERITAC-2 trial enrolled 624 patients across 213 sites in 25 countries, with 270 patients having ESR1 mutations [6][7]. - The primary endpoint of the trial was progression-free survival, with overall survival as a key secondary endpoint [7]. Regulatory Status - Vepdegestrant has been granted Fast Track designation by the FDA, highlighting the unmet medical need in the target patient population [5].