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Johnson & Johnson's dual-targeting CAR T-cell therapy shows encouraging first results in large B-cell lymphoma
Prnewswire· 2025-06-13 15:00
Core Insights - Johnson & Johnson announced promising results from a Phase 1b study of JNJ-90014496, a dual-targeting CAR T-cell therapy for relapsed or refractory large B-cell lymphoma, showing a 75-80% complete response rate among evaluable patients at the recommended Phase 2 dose [1][2] Company Overview - Johnson & Johnson is committed to advancing innovative therapies for patients with B-cell malignancies, emphasizing their long-term dedication to addressing unmet medical needs [2][4] - The company is expanding its pipeline of CAR T therapies through a collaboration with AbelZeta Inc. to develop next-generation CAR T-cell therapies [2][3] Industry Context - Large B-cell lymphoma, particularly diffuse large B-cell lymphoma, accounts for approximately 40% of all non-Hodgkin lymphoma cases globally, with an estimated 150,000 new cases diagnosed each year [3] - Current single-antigen-targeting CD19 CAR T therapies provide long-term remissions for only about 40% of patients, highlighting the need for innovative treatment options [2][3]
Levi & Korsinsky Notifies Avis Budget Group, Inc. Investors of a Class Action Lawsuit and Upcoming Deadline - CAR
Prnewswire· 2025-06-13 09:45
Core Viewpoint - A class action securities lawsuit has been filed against Avis Budget Group, Inc. alleging securities fraud that negatively impacted investors between February 16, 2024, and February 10, 2025 [1][2]. Group 1: Allegations of Fraud - The lawsuit claims that Avis Budget implemented a plan to significantly accelerate its fleet rotation in Q4 2024 [2]. - This acceleration allegedly shortened the useful life of most vehicles in the Americas segment, reducing their recoverable value [2]. - As a result, Avis Budget is expected to recognize billions of dollars in impairment charges and incur substantial losses [2]. - The financial and business prospects of Avis Budget were overstated, leading to materially false and misleading public statements [2]. Group 2: Legal Process and Participation - Investors who suffered losses during the relevant time frame have until June 24, 2025, to request appointment as lead plaintiff [3]. - Participation in the lawsuit does not require serving as a lead plaintiff, and there are no out-of-pocket costs for class members [3]. Group 3: Firm Background - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions for shareholders over the past 20 years [4]. - The firm has been recognized as one of the top securities litigation firms in the United States for seven consecutive years [4].
Investors in Avis Budget Group, Inc. Should Contact The Gross Law Firm Before June 24, 2025 to Discuss Your Rights - CAR
Prnewswire· 2025-06-12 09:45
Core Viewpoint - The Gross Law Firm has issued a notice to shareholders of Avis Budget Group, Inc. regarding a class action lawsuit alleging that the company made materially false and misleading statements during the class period from February 16, 2024, to February 10, 2025 [1] Group 1: Allegations Against Avis Budget Group - The complaint alleges that Avis Budget implemented a plan to significantly accelerate its fleet rotation in Q4 2024, which shortened the useful life of most vehicles in the Americas segment [1] - This acceleration is claimed to have reduced the recoverable value of the vehicles, leading to billions of dollars in impairment charges and substantial losses for the company [1] - As a result, the financial and business prospects of Avis Budget were overstated, and the public statements made by the defendants were materially false and misleading [1] Group 2: Class Action Details - Shareholders who purchased shares of CAR during the specified class period are encouraged to register for the class action, with a deadline of June 24, 2025, to seek lead plaintiff status [2] - Once registered, shareholders will be enrolled in a portfolio monitoring software to receive updates throughout the case lifecycle [2] - Participation in the case incurs no cost or obligation for the shareholders [2] Group 3: About the Gross Law Firm - The Gross Law Firm is a nationally recognized class action law firm dedicated to protecting the rights of investors affected by deceit, fraud, and illegal business practices [3] - The firm aims to ensure companies adhere to responsible business practices and seeks recovery for investors who suffered losses due to misleading statements or omissions [3]
ROSEN, A RANKED AND LEADING LAW FIRM, Encourages Avis Budget Group, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - CAR
GlobeNewswire News Room· 2025-06-12 00:14
Core Viewpoint - Rosen Law Firm is reminding investors who purchased Avis Budget Group, Inc. securities during the specified Class Period of the upcoming lead plaintiff deadline on June 24, 2025 [1]. Group 1: Class Action Details - Investors who purchased Avis Budget securities between February 16, 2024, and February 10, 2025, may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. - A class action lawsuit has already been filed, and interested parties can join by submitting a form or contacting the law firm [3][6]. - The lead plaintiff must file a motion with the Court by June 24, 2025, to represent other class members in the litigation [3]. Group 2: Law Firm Credentials - Rosen Law Firm emphasizes the importance of selecting qualified counsel with a successful track record in securities class actions, highlighting its own achievements in this area [4]. - The firm has secured significant settlements for investors, including over $438 million in 2019 alone, and has been consistently ranked among the top firms for securities class action settlements [4]. Group 3: Case Allegations - The lawsuit alleges that during the Class Period, Avis Budget made false and misleading statements regarding its fleet rotation plan, which negatively impacted the value of its vehicles and led to billions in impairment charges [5]. - The claims suggest that these misstatements resulted in significant financial losses for investors when the true situation was revealed [5].
Shareholders that lost money on Avis Budget Group, Inc.(CAR) should contact Levi & Korsinsky about pending Class Action - CAR
GlobeNewswire News Room· 2025-06-10 17:03
Core Viewpoint - Avis Budget Group, Inc. is facing a class action securities lawsuit due to alleged securities fraud that negatively impacted investors between February 16, 2024, and February 10, 2025 [1][2]. Group 1: Allegations and Impact - The lawsuit claims that Avis Budget implemented a plan to significantly accelerate its fleet rotation in Q4 2024, which shortened the useful life of most vehicles in the Americas segment [2]. - This acceleration is alleged to have reduced the recoverable value of the vehicles, leading to billions of dollars in impairment charges and substantial losses for the company [2]. - As a result, the financial and business prospects of Avis Budget were overstated, and the public statements made by the defendants were materially false and misleading [2]. Group 2: Legal Process and Participation - Investors who suffered losses during the specified timeframe have until June 24, 2025, to request appointment as lead plaintiff, although participation in any recovery does not require serving as a lead plaintiff [3]. - Class members may be entitled to compensation without any out-of-pocket costs or fees, indicating no financial obligation to participate in the lawsuit [3]. Group 3: Firm Background - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions of dollars for shareholders over the past 20 years [4]. - The firm has been recognized in ISS Securities Class Action Services' Top 50 Report for seven consecutive years, highlighting its expertise in complex securities litigation [4].
DEADLINE ALERT: Faruqi & Faruqi, LLP Investigates Claims on Behalf of Investors of Avis Budget Group
Prnewswire· 2025-06-10 13:40
Core Viewpoint - Faruqi & Faruqi, LLP is investigating potential claims against Avis Budget Group, Inc. due to significant financial losses attributed to misleading statements and a flawed fleet rotation strategy [2][4]. Group 1: Financial Performance - Avis Budget reported a loss of $1.96 billion, or $55.66 per share, for Q4 2024, compared to a profit of $259 million, or $7.10 per share, in the same period the previous year [5]. - The loss was primarily due to a one-time non-cash impairment of $2.3 billion and additional non-cash related charges of $180 million resulting from a strategy to accelerate fleet rotations [5]. Group 2: Legal Implications - A federal securities class action has been filed against Avis, with a deadline of June 24, 2025, for investors to seek the role of lead plaintiff [2][6]. - The complaint alleges that Avis and its executives violated federal securities laws by making false or misleading statements regarding the company's financial health and fleet management strategy [4]. Group 3: Management Changes - Following the financial report, CEO Joseph A. Ferraro will transition to a Board Advisor role effective June 30, 2025, with Brian Choi taking over as CEO on July 1, 2025 [5]. Group 4: Investor Outreach - Faruqi & Faruqi encourages investors who suffered losses exceeding $100,000 in Avis between February 16, 2024, and February 10, 2025, to contact them for legal options [1][7].
Avis Budget Group, Inc. Sued for Securities Law Violations - Contact Levi & Korsinsky Before June 24, 2025 to Discuss Your Rights - CAR
Prnewswire· 2025-06-10 09:45
Core Viewpoint - A class action securities lawsuit has been filed against Avis Budget Group, Inc. alleging securities fraud that negatively impacted investors between February 16, 2024, and February 10, 2025 [1][2]. Group 1: Allegations of Fraud - The lawsuit claims that Avis Budget implemented a plan to significantly accelerate its fleet rotation in Q4 2024, which shortened the useful life of most vehicles in the Americas segment [2]. - This acceleration is alleged to have led to billions of dollars in impairment charges and substantial losses for the company [2]. - The financial and business prospects of Avis Budget were reportedly overstated, and the public statements made by the defendants were materially false and misleading [2]. Group 2: Legal Process and Participation - Investors who suffered losses during the specified timeframe have until June 24, 2025, to request appointment as lead plaintiff, although participation in any recovery does not require serving as a lead plaintiff [3]. - Class members may be entitled to compensation without any out-of-pocket costs or fees, indicating no financial obligation to participate [3]. Group 3: Firm Background - Levi & Korsinsky, LLP has a history of securing hundreds of millions of dollars for shareholders and is recognized as one of the top securities litigation firms in the United States [4].
Avis Budget Group Announces Chief Financial Officer Transition
Globenewswire· 2025-06-09 20:00
Core Insights - Avis Budget Group, Inc. has appointed Daniel Cunha as Chief Financial Officer, effective July 1, 2025, succeeding Izzy Martins who will leave the company on June 30, 2025 [1][4] Company Leadership Changes - Daniel Cunha joins from Orion Services Group where he served as CFO for one year, and has prior experience as CFO at Ocean Spray and Heinz North America [2] - Izzy Martins will assist with the transition until August 31, 2025 [3] Strategic Direction - Brian Choi, the Chief Transformation Officer and incoming CEO, expressed confidence in Cunha's strategic financial leadership and operational expertise, which are expected to be crucial for executing the next phase of the company's strategic plan [4] Company Overview - Avis Budget Group is a leading global provider of mobility solutions with approximately 10,250 rental locations in around 180 countries, operating primarily in North America, Europe, and Australasia [5]
Avis Budget Group, Inc. Sued for Securities Law Violations – Investors Should Contact The Gross Law Firm Before June 24, 2025 to Discuss Your Rights – CAR
GlobeNewswire News Room· 2025-06-09 17:32
NEW YORK, June 09, 2025 (GLOBE NEWSWIRE) -- The Gross Law Firm issues the following notice to shareholders of Avis Budget Group, Inc. (NASDAQ: CAR). Shareholders who purchased shares of CAR during the class period listed are encouraged to contact the firm regarding possible lead plaintiff appointment. Appointment as lead plaintiff is not required to partake in any recovery. CONTACT US HERE: https://securitiesclasslaw.com/securities/avis-budget-loss-submission-form/?id=151934&from=3 CLASS PERIOD: February 16 ...
Anixa Biosciences Announces Poster Presentation on Ovarian Cancer CAR-T Clinical Trial at the ESMO Gynaecological Cancers Congress 2025
Prnewswire· 2025-06-09 12:00
SAN JOSE, Calif., June 9, 2025 /PRNewswire/ -- Anixa Biosciences, Inc. ("Anixa" or the "Company") (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer, today announced that Dr. Robert Wenham, Chair of the Gynecologic Oncology Program at Moffitt Cancer Center, and the principal investigator of the Phase 1 clinical trial of Anixa's ovarian cancer CAR-T immunotherapy, will present an e-poster at the European Society for Medical Oncology ("ESMO") Gynaecological Cancers Congr ...