Company Overview - CRISPR Therapeutics AG (CRSP) is expected to report a quarterly loss of $1.47 per share, reflecting a year-over-year change of +1.3% [3] - Revenues are anticipated to be $6.58 million, representing a significant increase of 1165.4% from the same quarter last year [3] Earnings Estimates and Revisions - The consensus EPS estimate has been revised 1.75% lower over the last 30 days, indicating a reassessment by analysts [4] - The Most Accurate Estimate for CRISPR Therapeutics is lower than the Zacks Consensus Estimate, resulting in an Earnings ESP of -11.09% [12] Earnings Surprise Prediction - A positive Earnings ESP is a strong predictor of an earnings beat, particularly when combined with a favorable Zacks Rank [10] - CRISPR Therapeutics currently holds a Zacks Rank of 4, which complicates the prediction of an earnings beat [12] Historical Performance - In the last reported quarter, CRISPR Therapeutics was expected to post a loss of $1.27 per share but actually reported a loss of -$1.58, resulting in a surprise of -24.41% [13] - Over the past four quarters, the company has beaten consensus EPS estimates two times [14] Industry Context - Another player in the biomedical and genetics industry, Illumina (ILMN), is expected to post earnings of $1.02 per share, indicating a year-over-year change of +183.3% [18] - Illumina's revenues are projected to be $1.05 billion, down 5.8% from the previous year, with a slight downward revision of 0.2% in the consensus EPS estimate over the last 30 days [19]

Group 1 - CRISPR Therapeutics AG (CRSP) has an average brokerage recommendation (ABR) of 1.88, indicating a consensus between Strong Buy and Buy based on 27 brokerage firms' recommendations [2] - Out of the 27 recommendations, 15 are classified as Strong Buy, accounting for 55.6%, while one is classified as Buy, accounting for 3.7% [2] - Despite the positive ABR, caution is advised as studies show limited success of brokerage recommendations in predicting stock price increases [5][10] Group 2 - Brokerage analysts tend to exhibit a strong positive bias in their ratings due to vested interests, with five Strong Buy recommendations for every Strong Sell [6][10] - The Zacks Rank, a proprietary stock rating tool, is highlighted as a more reliable indicator of near-term price performance, based on earnings estimate revisions [8][11] - The Zacks Consensus Estimate for CRISPR Therapeutics remains unchanged at -$5.54, suggesting the stock may perform in line with the broader market [13][14] Group 3 - The Zacks Rank for CRISPR Therapeutics is currently 3 (Hold), indicating a more cautious stance compared to the Buy-equivalent ABR [14] - The ABR is not always up-to-date, while the Zacks Rank reflects timely earnings estimate revisions, making it a more current indicator of future price movements [12]

Core Insights - The article discusses the author's transition to independent investment research after over 43 years in the industry, emphasizing a focus on actionable investment insights rather than adhering to external agendas [1] - The author specializes in rules and factor-based equity investing strategies, combining quantitative analysis with fundamental analysis to derive investment stories that predict future performance [1] - The author has extensive experience across various market segments, including large cap, small cap, micro cap, value, growth, and income stocks, as well as managing a high-yield fixed-income fund [1] Group 1 - The author aims to provide the best actionable investment insights without being influenced by any product agenda [1] - The approach taken is to use numbers as a tool to inspire human intelligence-driven investment narratives rather than relying solely on statistical studies [1] - The author has a background in investor education, having conducted seminars and authored books on stock selection and analysis [1] Group 2 - The author has developed and worked with various quantitative models and has experience in quantitative asset allocation strategies, which are foundational to modern Robo Advising [1] - The article highlights the author's previous roles, including editing stock newsletters and serving as an assistant research director at Value Line [1] - The author expresses openness to feedback and criticism from readers, indicating a willingness to engage with the investment community [1]

Group 1: Stock Performance - CRISPR Therapeutics AG shares increased by 9.6% to close at $60.08, with notable trading volume compared to typical sessions [1] - The stock has gained 27.7% over the past four weeks, indicating strong investor interest [1] Group 2: Pipeline Developments - The rise in CRISPR's stock price is attributed to positive sentiment regarding its pipeline, particularly the in vivo candidate CTX310 targeting ANGPTL3 for atherosclerotic heart disease [2] - Updated data from an early-stage study showed a single dose of CTX310 resulted in peak reductions of up to 82% in triglyceride levels and up to 86% in LDL levels, generating excitement for other pipeline candidates [2] Group 3: Financial Expectations - The company is expected to report a quarterly loss of $1.54 per share, reflecting a year-over-year change of -3.4%, while revenues are projected at $5.89 million, a significant increase of 1032.9% from the previous year [3] - The consensus EPS estimate for the quarter has remained unchanged over the last 30 days, suggesting that stock price movements may be influenced by trends in earnings estimate revisions [4] Group 4: Industry Context - CRISPR Therapeutics is part of the Zacks Medical - Biomedical and Genetics industry, where Wave Life Sciences also operates, closing the last trading session 10.8% higher at $7.7 [4] - Wave Life Sciences has seen a consensus EPS estimate change of -6.6% over the past month, indicating a potential decline in performance compared to the previous year [5]

Company Performance - CRISPR Therapeutics AG (CRSP) ended the recent trading session at $51.19, showing a -1.88% change from the previous day's closing price, which lagged behind the S&P 500's daily loss of 0.79% [1] - The stock has risen by 24.63% in the past month, outperforming the Medical sector's gain of 1.49% and the S&P 500's gain of 5.22% [1] Financial Forecast - The company is forecasted to report an EPS of -$1.54, reflecting a 3.36% decrease from the same quarter of the previous year [2] - Quarterly revenue is expected to be $5.89 million, representing a significant increase of 1032.88% from the year-ago period [2] Full-Year Estimates - Full-year Zacks Consensus Estimates predict earnings of -$5.54 per share and revenue of $39.95 million, indicating year-over-year changes of -27.65% and +7.06%, respectively [3] - Recent changes to analyst estimates for CRISPR Therapeutics AG can indicate short-term business trends, with positive revisions seen as a favorable sign for the business outlook [3] Zacks Rank and Industry Performance - The Zacks Rank system, which includes estimate changes, has a proven track record of outperformance, with 1 stocks returning an average of +25% annually since 1988 [5] - CRISPR Therapeutics AG currently holds a Zacks Rank of 3 (Hold), with the consensus EPS estimate remaining stagnant over the past month [5] - The Medical - Biomedical and Genetics industry, part of the Medical sector, has a Zacks Industry Rank of 77, placing it within the top 32% of over 250 industries [6]

Group 1: CRISPR Therapeutics - CRISPR Therapeutics has developed Casgevy, the first gene-editing medicine approved using the CRISPR technique, but the stock has been on a downward trend since 2021 due to clinical progress, complexity of therapy administration, and unprofitability [3][4] - The company is targeting challenging areas such as type 1 diabetes and hard-to-treat cancers, with expected data readouts for ongoing clinical trials as early as this year, which could positively impact stock performance [5] - Casgevy has significant financial implications, with a treatment cost of $2.2 million in the U.S. and an estimated 60,000 patients in target geographies, indicating blockbuster potential [9] Group 2: Viking Therapeutics - Viking Therapeutics gained attention after strong phase 2 results for VK2735, an investigational weight management therapy, but has seen stock performance decline as investors took profits [10] - The anti-obesity therapy market is rapidly growing, and Viking's VK2735 has shown promising mid-stage data, with an oral formulation currently in Phase 2 studies [11] - Viking Therapeutics has a robust pipeline, including VK2809 for metabolic dysfunction-associated steatohepatitis entering phase 3 studies and VK0214 for X-linked adrenoleukodystrophy, which has received orphan drug designation [12][13]

Core Insights - The healthcare sector is highlighted as having significant growth opportunities, particularly in the weight loss drug market and gene editing technologies [2][4]. Group 1: Weight Loss Drug Market - Eli Lilly is positioned to potentially lead the GLP-1 agonist market, currently holding approximately 35% market share, while Novo Nordisk leads with 65% [4]. - The GLP-1 market is projected to grow to a $150 billion opportunity over the next decade, representing a tenfold increase from last year's sales [4]. - Eli Lilly is developing two promising drugs: Orforglipron, an oral GLP-1 pill, and Retatrutide, which targets multiple hormones and is in phase 3 studies [5][6]. - Analysts anticipate Eli Lilly will achieve 32% annualized earnings growth over the long term, despite a high price-to-earnings (P/E) ratio of nearly 65 [7][8]. Group 2: Gene Editing Technology - CRISPR Therapeutics is advancing its commercialization efforts for Casgevy, a therapy for sickle cell disease and beta-thalassemia, which is the first CRISPR-based treatment to receive FDA approval [10]. - The company has five additional therapies in clinical trials, indicating potential for significant growth if successful [11]. - Analysts project CRISPR Therapeutics will achieve $173 million in revenue next year, with an enterprise value of $2.2 billion, suggesting a reasonable price for the stock given its potential [12].

Core Insights - CRISPR Therapeutics has been recognized in the TIME 100 Most Influential Companies list for its pioneering work in gene editing [1][2][3] - The company is expanding its focus beyond sickle cell disease and beta thalassemia to address significant unmet medical needs in cardiovascular and autoimmune diseases [2][4] - The recognition by TIME reflects the company's commitment to transforming medicine through innovation and collaboration [3] Company Overview - CRISPR Therapeutics has evolved from a research-stage company to a leader in gene editing, celebrating the approval of the first-ever CRISPR-based therapy [4] - The company has a diverse portfolio targeting various disease areas, including hemoglobinopathies, oncology, regenerative medicine, cardiovascular, autoimmune, and rare diseases [4] - The first CRISPR/Cas9 gene-edited therapy was advanced into clinical trials in 2018, with CASGEVY (exa-cel) approved in several countries starting late 2023 for treating eligible patients [4] Strategic Partnerships - To enhance its capabilities, CRISPR Therapeutics has formed strategic partnerships with leading companies, including Vertex Pharmaceuticals [4] Recognition and Impact - TIME's selection process involved evaluating companies based on impact, innovation, ambition, and success, highlighting CRISPR Therapeutics' role in shaping the future of business and society [3]

Group 1 - CRISPR Therapeutics AG (CRSP) has an average brokerage recommendation (ABR) of 1.88, indicating a consensus between Strong Buy and Buy based on 27 brokerage firms' recommendations [2] - Out of the 27 recommendations, 15 are Strong Buy and 1 is Buy, which accounts for 55.6% and 3.7% of all recommendations respectively [2] - Despite the positive ABR, relying solely on this information for investment decisions may not be advisable, as studies show brokerage recommendations often lack success in guiding investors towards stocks with high price appreciation potential [5][10] Group 2 - Brokerage analysts tend to exhibit a strong positive bias in their ratings due to vested interests, with five "Strong Buy" recommendations for every "Strong Sell" [6][10] - The Zacks Rank, a proprietary stock rating tool, categorizes stocks from Zacks Rank 1 (Strong Buy) to Zacks Rank 5 (Strong Sell) and is based on earnings estimate revisions, making it a more effective indicator of near-term stock price performance [8][11] - The Zacks Consensus Estimate for CRISPR Therapeutics remains unchanged at -$5.54, suggesting that analysts' steady views on earnings prospects may lead to stock performance in line with the broader market [13][14]

Industry Overview - The field of genomics has rapidly evolved over the past decade, focusing on the complete set of genes and their interactions rather than individual genes [1] - Genomics is pivotal for developing targeted therapies, leading to a revolutionary era in genetic medicine, attracting significant attention from pharmaceutical and biotech companies [2] Technological Innovations - Synthetic biology, which applies engineering principles to biology, has emerged as a key concept within genomics, aiding in drug discovery, disease detection, and gene editing [3] - The cost, accuracy, and time required to map an individual's genome have drastically reduced, enhancing the spotlight on genomics companies [4] Market Potential - The genomics market is projected to reach $157.47 billion by 2033, while the global synthetic biology market was valued at $16.22 billion in 2024, with a projected CAGR of 17.30% from 2025 to 2030 [6] Company Highlights - MeiraGTx Holdings plc is focused on genetic medicine with a pipeline addressing conditions like Parkinson's disease and retinal dystrophy, showing promising efficacy data [8][9] - Beam Therapeutics is advancing base editing programs for genetic diseases, with FDA orphan drug designation for its BEAM-101 treatment for sickle cell disease [12][13] - Krystal Biotech received FDA approval for Vyjuvek, the first gene therapy for dystrophic epidermolysis bullosa, and is advancing a pipeline in various therapeutic areas [14][15]