CRISPR Therapeutics AG (NASDAQ:CRSP) Jefferies London Healthcare Conference November 20, 2024 11:00 AM ET Company Participants Samarth Kulkarni - Chief Executive Officer and Chairman Conference Call Participants Maury Raycroft - Jefferies Maury Raycroft Hi, everyone. My name is Maury Raycroft, I'm one of the biotech analysts at Jeffreys. I'd like to welcome Sam Kulkarni, the CEO of CRISPR Therapeutics. Sam, thanks so much for joining us today. Samarth Kulkarni Thank you for having me. Maury Raycroft And we' ...

CRISPR Therapeutics’ (CRSP) shares have lost 6.6% in the past two weeks compared with the industry’s 8.4% decline, as seen in the chart below. The stock has underperformed the sector and the S&P 500 index. Shares of the company are also currently trading below its 50-day and 200-day moving averages.CRSP Stock Performance Image Source: Zacks Investment ResearchThe drop in the share price is likely due to the decline of the drug/biotech sector in the past couple of months due to lower-than-expected third-quar ...

Biotechs often need several years to realize their visions, even after they have a drug approved for the first time. There's typically plenty of upside in store for enterprising and patient investors.Here are two such opportunities that are ripe for buying today, provided that you're willing to hold on to your shares for at least five years.1. CRISPR TherapeuticsWith a bunch of gene therapy and gene editing programs in clinical trials, CRISPR Therapeutics (CRSP 0.85%) has an impressive resume already, but i ...

CRISPR Therapeutics AG (NASDAQ:CRSP) Guggenheim Inaugural Healthcare Innovation Conference November 12, 2024 2:00 PM ET Company Participants Samarth Kulkarni - CEO and Chairman Conference Call Participants Debjit Chattopadhyay - Guggenheim Partners Debjit Chattopadhyay Good afternoon and thank you for joining us at Guggenheim's Inaugural Healthcare Innovations Conference. I am Debjit and one of the therapeutic analysts here. And joining me today is Samarth Kulkarni, CEO and Chairman of CRISPR Therapeutics. ...

CRISPR Therapeutics AG (NASDAQ:CRSP) Guggenheim Inaugural Healthcare Innovation Conference November 12, 2024 2:00 PM ET Company Participants Samarth Kulkarni - CEO and Chairman Conference Call Participants Debjit Chattopadhyay - Guggenheim Partners Debjit Chattopadhyay Good afternoon and thank you for joining us at Guggenheim's Inaugural Healthcare Innovations Conference. I am Debjit and one of the therapeutic analysts here. And joining me today is Samarth Kulkarni, CEO and Chairman of CRISPR Therapeutics. ...

Core Insights - CRISPR Therapeutics aims to evolve from a pioneering gene therapy company into a broader biotech powerhouse over the next three years, focusing on expanding its pipeline and collaborations while still facing potential losses [1][2]. Group 1: Business Strategy and Pipeline Expansion - The company plans to initiate one or two new investigational drug programs annually, targeting new diseases and treatment areas beyond its current focus [3]. - CRISPR will continue to develop its first approved medicine, Casgevy, while also exploring new therapeutic areas such as cardiovascular disease and type 1 diabetes [4][5]. Group 2: Financial Position and Funding Needs - As of the end of Q3, CRISPR holds approximately $1.9 billion in cash and equivalents, with no debt but $210.6 million in operating lease liabilities, indicating a strong financial position [6]. - The company anticipates ongoing losses for the next few years, necessitating future capital raises through debt issuance or secondary stock sales [6]. Group 3: Collaborations and Manufacturing - CRISPR is likely to pursue more collaboration agreements, similar to its partnership with Vertex Pharmaceuticals, to leverage its strengths in genetic medicine development while outsourcing other operational aspects [7]. - The company plans to enhance its manufacturing capabilities, particularly for cell therapies, to reduce costs and streamline future product rollouts [8].

Core Insights - CRISPR Therapeutics will present at the Jefferies London Healthcare Conference on November 20, 2024, at 4:00 p.m. GMT [1] - A live webcast of the presentation will be available on the company's website, with a replay archived for 14 days [2] Company Overview - CRISPR Therapeutics has evolved from a research-stage company to a leader in gene-based medicines, recently achieving the historic approval of the first CRISPR-based therapy [3] - The company has a diverse portfolio targeting various diseases, including hemoglobinopathies, oncology, regenerative medicine, cardiovascular, autoimmune, and rare diseases [3] - The first CRISPR/Cas9 gene-edited therapy was advanced into clinical trials in 2018 for sickle cell disease and beta thalassemia, with CASGEVY (exa-cel) approved in some countries starting late 2023 [3] - CRISPR Therapeutics has established strategic partnerships with Bayer and Vertex Pharmaceuticals to enhance its research and development efforts [3] - The company is headquartered in Zug, Switzerland, with R&D operations in Boston and San Francisco, and business offices in London [3]

Group 1 - The marketplace channel Haggerston BioHealth offers exclusive stock tips focused on Pharma, Biotech, and Healthcare, providing access to investment bank-grade financial models and research [1][2] - The group caters to both novice and experienced biotech investors, offering insights on catalysts, buy and sell ratings, product sales forecasts, and integrated financial statements [2] - Edmund Ingham, a biotech consultant with over 5 years of experience, leads the Haggerston BioHealth investing group and has compiled detailed reports on over 1,000 companies [2]

Shares of CRISPR Therapeutics AG (CRSP) have gained 11.4% over the past four weeks to close the last trading session at $50.36, but there could still be a solid upside left in the stock if short-term price targets of Wall Street analysts are any indication. Going by the price targets, the mean estimate of $81.96 indicates a potential upside of 62.8%.The mean estimate comprises 24 short-term price targets with a standard deviation of $34.57. While the lowest estimate of $30 indicates a 40.4% decline from the ...

Core Insights - CRISPR Therapeutics reported a narrower loss of $1.01 per share for Q3 2024, compared to the Zacks Consensus Estimate of a loss of $1.33 and a loss of $1.41 per share in the same period last year [1] - Total revenues were $0.6 million, primarily from grant revenues, significantly missing the Zacks Consensus Estimate of $6.4 million [1] - The company had cash and equivalents of $1.9 billion as of September 30, 2024, down from $2.0 billion as of June 30, 2024 [3] Financial Performance - Research and development expenses decreased by 9% year over year to $82.2 million due to reduced external research and manufacturing costs [2] - General and administrative expenses fell by 5% year over year to $17.4 million [2] - Collaboration expenses were $11.2 million, down 52% year over year, mainly due to delays in reaching the deferral limit on costs related to the Casgevy program [2] Pipeline Developments - CRISPR and Vertex Pharmaceuticals' gene therapy, Casgevy, was approved for sickle cell disease and transfusion-dependent beta thalassemia in late 2023/early 2024 [5] - More than 45 authorized treatment centers have been activated globally since mid-October, with Vertex reporting $2 million in product revenues from Casgevy sales [6] - CRISPR is developing next-generation CAR-T therapies, CTX112 and CTX131, currently in separate phase I/II studies, with preliminary data from CTX131 expected by the end of 2024 [7] Future Plans - Management is exploring additional indications for next-generation candidates and has initiated two new clinical studies for CTX131 and CTX112 [8] - The company is studying its first two in-vivo candidates, CTX310 and CTX320, in separate phase I clinical studies [9] - Plans to expand the in-vivo pipeline with CTX340 and CTX450 are underway, with clinical studies expected to start in the second half of 2025 [10] Market Performance - Shares of CRISPR Therapeutics have declined by 19.5% year-to-date, compared to a 3.8% decline in the industry [3] - The company currently holds a Zacks Rank 2 (Buy) [11]