Core Insights - Angry Orchard Hard Cider has launched its new product, the "World's Angriest" cider, which is described as its boldest creation to date, infused with real anger and spicy peppers [1][3] - The cider is made using Aji Amarillo and Habanero peppers, steeped for over six months, resulting in a unique flavor profile that incorporates the essence of anger from fans [1][4] - The product is positioned as a humorous take on holiday frustrations, encouraging consumers to channel their anger into enjoying a spicy beverage [3] Product Details - The "World's Angriest" cider is available nationwide in 750mL bottles, priced at $25 each [7] - The cider is crafted with locally sourced honey to balance the heat from the peppers, creating a spicy yet enjoyable flavor [4] - Angry Orchard has been experimenting with spice for the past year, leading to the development of this ultra-spicy batch [4] Marketing Strategy - The company engaged fans by allowing them to vent their frustrations through a national hotline, which contributed to the cider's unique ingredient [1][2] - The marketing emphasizes humor and the idea of embracing life's irritations, making the cider a fitting choice for holiday gatherings [3] - Angry Orchard aims to create a memorable experience for consumers by infusing real emotions into the product [2][3]

Core Insights - Cyclacel Pharmaceuticals is developing plogosertib, a PLK1 inhibitor, as a potential treatment for fibrolamellar hepatocellular carcinoma (FLC), a rare liver cancer with no approved therapies [1][2][5] Group 1: Disease Overview - FLC primarily affects adolescents and young adults, with an estimated annual incidence in the US of 0.02 per 100,000 [3] - The five-year survival rate for FLC patients is approximately 30%, and the disease is often misdiagnosed as hepatocellular carcinoma (HCC) [3] - FLC is characterized by the presence of a unique DNAJB1-PKAc gene fusion, which is a common driver of the disease [4] Group 2: Research Findings - A recent study published in the journal Gut indicates that the DNAJ-PKAc fusion oncoprotein increases sensitivity to PLK1 inhibitors like plogosertib in FLC cells [1][2] - PLK1 is essential for the growth of FLC cells, and its inhibition leads to significant reduction in FLC growth while sparing normal liver cells [2] - The study suggests further evaluation of plogosertib in preclinical and clinical studies for FLC treatment [2] Group 3: Drug Development - Plogosertib is a selective and potent PLK1 inhibitor that has shown efficacy in human tumor xenografts at non-toxic doses [7] - Initial Phase 1 clinical study data indicate that plogosertib is well tolerated with no dose-limiting toxicity observed [8] - Cyclacel's strategy includes developing plogosertib for various solid tumors and hematological malignancies, with a focus on cancers associated with DNAJ-PKAc fusions [10]

Shower Trulys, The Official Shower Beverage of U.S. Soccer Everyone knows that the official pregame starts in the shower. So, this summer, Truly wants fans to forget the traditional 'shower beer' and instead enjoy a victory "Shower Truly" – the newly minted Official Shower Beverage of U.S. Soccer. Long-term Shower Truly fan and USMNT midfielder, Weston McKennie, introduces the world to his post-game pre-game tradition while debuting in Truly's latest "steamy" ad spot, while USMNT teammate Tyler Adams patien ...