Core Insights - Premarket trading is showing notable activity with significant price movements indicating potential trading opportunities before the market opens [1] Premarket Gainers - Qualigen Therapeutics, Inc. (QLGN) increased by 69% to $6.00 - Inhibrx Biosciences, Inc. (INBX) rose by 62% to $46.04 - MidWestOne Financial Group, Inc. (MOFG) gained 33% to $37.87 - Neuphoria Therapeutics Inc. (NEUP) up by 31% to $5.32 - Nextracker Inc. (NXT) increased by 13% to $102.44 - Avalon Holdings Corporation (AWX) rose by 11% to $2.98 - Beyond Meat, Inc. (BYND) up by 9% to $3.12 - SLM Corporation (SLM) increased by 8% to $29.00 - Reborn Coffee, Inc. (REBN) rose by 7% to $2.40 - Oriental Culture Holding LTD (OCG) increased by 5% to $3.55 [3] Premarket Losers - Picard Medical, Inc. (PMI) decreased by 70% to $3.89 - Fusemachines Inc. Common stock (FUSE) down by 17% to $3.29 - American Rebel Holdings, Inc. (AREB) fell by 16% to $3.14 - Armata Pharmaceuticals, Inc. (ARMP) down by 13% to $6.16 - Coya Therapeutics, Inc. (COYA) decreased by 13% to $6.01 - Deckers Outdoor Corporation (DECK) down by 12% to $90.00 - Safe & Green Holdings Corp. (SGBX) fell by 12% to $2.58 - Beasley Broadcast Group, Inc. (BBGI) decreased by 8% to $5.55 - Booz Allen Hamilton Holding Corporation (BAH) down by 7% to $92.73 - Brera Holdings PLC (SLMT) decreased by 6% to $10.67 [4]

Core Insights - Inhibrx Biosciences Inc. shares experienced a significant increase of 75.95% in after-hours trading, closing at $49.90 after a regular trading session where the stock fell by 10.03% to $28.36 [1][6] Study Results - The company announced positive topline results from the ChonDRAgon study, a Phase 2 trial evaluating ozekibart (INBRX-109) for patients with advanced or metastatic, unresectable chondrosarcoma [2][4] - The study, involving 206 patients, met its primary endpoint, demonstrating a statistically significant improvement in median progression-free survival (PFS) [3] - Ozekibart reduced the risk of disease progression or death by 52% compared to placebo, with a median PFS of 5.52 months versus 2.66 months for placebo [3] Additional Data - Ozekibart is noted as the first experimental therapy to show a progression-free survival benefit in a randomized trial for chondrosarcoma, a cancer lacking approved systemic treatments [4] - Expansion cohort results indicated a 23% overall response rate for ozekibart combined with FOLFIRI in late-line colorectal cancer patients, and a 64% overall response rate when combined with irinotecan and temozolomide in refractory Ewing sarcoma patients [5] Stock Performance - Inhibrx's stock has increased by 84.16% year-to-date, although it has fallen 25.8% from its year-to-date high of $38.22 [6] - The stock has a 52-week range of $10.80 to $39.27 and a market capitalization of $410.81 million [6]

Core Insights - Biotech stocks experienced significant gains in after-hours trading, with Inhibrx Biosciences leading the surge due to positive trial results [1][2] Company Summaries - **Inhibrx Biosciences (INBX)**: Shares surged over 81% to $51.52 following positive topline results from the ChonDRAgon study, which evaluated ozekibart as a monotherapy for advanced chondrosarcoma. The company also reported progress on expansion cohorts for colorectal cancer and Ewing sarcoma [2] - **Femasys Inc. (FEMY)**: Stock increased by more than 18% to $0.7227 after launching a post-market surveillance clinical study for its FemBloc Permanent Birth Control, complying with EU Medical Device Regulation [3] - **Cingulate Inc. (CING)**: Shares rose over 6% to $3.80 after announcing that data from its ADHD candidate CTx-1301 was selected for presentation at the AACAP Annual Meeting, highlighting its potential in ADHD treatment [4] - **Community Health Systems, Inc. (CYH)**: Stock increased over 4% to $3.41 following positive Q3 results [5] - **Reviva Pharmaceuticals Holdings Inc. (RVPH)**: Shares climbed over 10% to $0.6295 in after-hours trading [6] - **Ascendis Pharma A/S (ASND)**: Stock gained more than 4%, reaching $210.68 post-market [6] - **ADC Therapeutics SA (ADCT)**: Shares rose over 5% to $4.2887 in after-hours trading [6] - **Zura Bio Limited (ZURA)**: Stock increased more than 5% to $3.55 post-market [6] - **Foghorn Therapeutics Inc. (FHTX)**: Shares gained more than 5%, closing at $4.11 after hours [6]

Inhibrx Biosciences said on Thursday its experimental drug helped slow the progression of a rare and aggressive bone cancer in a mid-stage trial, sending its shares surging over 70% in extended tradin... ...

Core Insights - Inhibrx Biosciences announced positive topline results from the ChonDRAgon study, demonstrating the efficacy of ozekibart (INBRX-109) in treating advanced or metastatic chondrosarcoma, achieving a statistically significant improvement in median progression-free survival (PFS) compared to placebo [1][2][6] Chondrosarcoma Study Results - The ChonDRAgon study met its primary endpoint, showing a 52% reduction in the risk of disease progression or death with ozekibart, resulting in a median PFS of 5.52 months versus 2.66 months for placebo [2][6] - Ozekibart is the first investigational therapy to show a significant PFS benefit in a randomized trial for chondrosarcoma, a condition lacking approved systemic treatments [2][6] - Key secondary endpoints indicated a disease control rate of 54% for ozekibart compared to 27.5% for placebo, along with improvements in pain and physical function [3][6] Safety Profile - Ozekibart was generally well tolerated, with common treatment-related adverse events including fatigue, constipation, and nausea. The incidence of treatment-related hepatic adverse events was 11.8% compared to 4.5% in the placebo group [4][10] - Hepatotoxicity was managed effectively through patient selection and monitoring, resulting in a low overall incidence of severe liver-related adverse events [4][10] Expansion Cohorts - Inhibrx is conducting expansion cohorts for ozekibart in combination with FOLFIRI for colorectal cancer and with irinotecan and temozolomide for Ewing sarcoma, showing promising early results [6][15] - Initial results from the colorectal cancer trial indicated a 23% overall response rate and a 92% disease control rate in a heavily pretreated patient population [7][8] - For Ewing sarcoma, the combination therapy showed a 64% overall response rate and a 92% disease control rate among evaluable patients [9][10] Future Plans - The company plans to file a Biologics License Application (BLA) for ozekibart in Q2 of 2026, aiming to expedite its availability to patients [6][10] - Detailed results from the ChonDRAgon study will be presented at the Connective Tissue Oncology Society Annual Meeting on November 14, 2025 [5][6]

Core Insights - Biotech stocks experienced significant gains in after-hours trading on October 22, 2023, primarily driven by Ventyx Biosciences' positive Phase 2 data, which led to an 88% surge in its stock price [1][2]. Company Performance - Ventyx Biosciences Inc. (VTYX) saw its shares increase by over 88% following the announcement of positive results from its Phase 2 study of VTX3232 for patients with obesity and cardiovascular risk factors [2]. - Medpace Holdings, Inc. (MEDP) reported better-than-expected Q3 results, resulting in an over 18% increase in its stock price during after-hours trading [2]. - Inhibrx Biosciences Inc. (INBX) shares rose over 10% to $34.98 after announcing a live webcast presentation to discuss topline results from the ChonDRAgon study [3]. - SCYNEXIS Inc. (SCYX) shares increased by over 11% to $0.87 [4]. - Acumen Pharmaceuticals Inc. (ABOS) experienced a notable rise of over 24.9% to $2.31 [4]. - Rani Therapeutics Holdings Inc. (RANI) shares were up over 9% at $2.64 [4]. - iBio Inc. (IBIO) shares increased by over 7% to $1.50 [4]. - Chemomab Therapeutics Ltd. (CMMB) shares rose over 7% to $3.32 [4]. - Nautilus Biotechnology Inc. (NAUT) shares increased by over 7% to $1.35 [4]. - ProQR Therapeutics N.V. (PRQR) shares were up over 7% at $2.92 [4]. - Tyra Biosciences Inc. (TYRA) shares increased by over 7% to $15.00 [4]. - Imunon Inc. (IMNN) shares rose over 4% to $4.90 [4].

Core Insights - Inhibrx Biosciences, Inc. will host a live webcast on October 23, 2025, to present topline results from the ChonDRAgon study of ozekibart (INBRX-109) for advanced chondrosarcoma [1] - The company will also provide updates on ongoing trials of ozekibart in combination therapies for colorectal cancer and Ewing sarcoma [1] Company Overview - Inhibrx is a clinical-stage biopharmaceutical company focused on developing therapeutics for oncology and rare diseases [1][5] - The company utilizes diverse protein engineering methods to create novel biologic therapeutic candidates [5] Product Information - Ozekibart (INBRX-109) is a tetravalent death receptor 5 (DR5) agonist antibody designed to induce tumor-biased cell death [3] - The FDA granted Fast Track designation for ozekibart in January 2021 and orphan drug designation in November 2021 for chondrosarcoma [3] Clinical Trials - A Phase 2 trial of ozekibart in metastatic, unresectable conventional chondrosarcoma was initiated in June 2021 [4] - Ongoing Phase 1/2 trials are investigating ozekibart in combination with FOLFIRI for colorectal cancer and with irinotecan/temozolomide for Ewing sarcoma [4]

Industry Overview - Inhibrx Biosciences, Inc. operates in the competitive biotechnology sector, focusing on protein-based therapeutics for cancer and serious diseases, alongside competitors like Keros Therapeutics, Kymera Therapeutics, iTeos Therapeutics, Harmony Biosciences Holdings, and Vaxcyte [1] Financial Analysis of Inhibrx Biosciences - The company's Return on Invested Capital (ROIC) is -95.25%, significantly lower than its Weighted Average Cost of Capital (WACC) of 8.16%, indicating insufficient returns to cover capital costs [2] - The ROIC to WACC ratio of -11.67 highlights inefficiencies in capital utilization [2] Comparison with Competitors - Keros Therapeutics has a ROIC of 0.03% and a WACC of 8.47%, resulting in a ROIC to WACC ratio of 0.0035, indicating minimal efficiency [3] - Kymera Therapeutics and iTeos Therapeutics report negative ROICs of -29.50% and -42.54%, respectively, with ROIC to WACC ratios of -2.17 and -4.03, reflecting challenges in generating adequate returns [3] - Harmony Biosciences Holdings stands out with a ROIC of 21.25% and a WACC of 7.65%, leading to a ROIC to WACC ratio of 2.78, indicating effective capital utilization [4] - Vaxcyte shows a ROIC of -22.46% and a WACC of 8.40%, with a ROIC to WACC ratio of -2.67, further illustrating inefficiencies in capital utilization [5] Summary of Financial Health - The analysis reveals varying degrees of financial health and capital efficiency among biotechnology companies, with Inhibrx Biosciences facing significant challenges in generating returns that cover its cost of capital [5]

Core Viewpoint - Inhibrx Biosciences, Inc. reported its financial results for Q2 2025, highlighting a significant decrease in both revenue and net income compared to the same period in 2024, following the completion of the 101 Transaction and the spin-off from its former parent company [1][4]. Financial Results - As of June 30, 2025, Inhibrx had cash and cash equivalents of $186.6 million, down from $216.5 million as of March 31, 2025 [4]. - Revenue for Q2 2025 was $1.3 million, a substantial increase from $0.1 million in Q2 2024 [4][7]. - Research and development expenses were $22.3 million in Q2 2025, significantly lower than $67.6 million in Q2 2024, primarily due to the elimination of costs associated with the INBRX-101 program following the 101 Transaction [4][8]. - General and administrative expenses decreased to $6.4 million in Q2 2025 from $93.4 million in Q2 2024, reflecting the absence of non-recurring expenses related to the 101 Transaction [4][8]. - The company reported a net loss of $28.7 million in Q2 2025, compared to a net income of $1.9 billion in Q2 2024, largely due to the prior year's gain from the 101 Transaction [4][8]. Upcoming Milestones - The ozekibart (INBRX-109) Phase 2 trial in unresectable or metastatic conventional chondrosarcoma has completed full enrollment, with results expected by late October 2025 [4]. - Initial Phase 2 data from the INBRX-106 trial in head and neck squamous cell carcinoma, in combination with KEYTRUDA®, is anticipated in Q4 2025 [4].

Core Viewpoint - Inhibrx Biosciences, Inc. announces significant leadership changes with the departure of co-founder and Chief Scientific Officer Dr. Brendan Eckelman, who will establish a new private biotechnology company, and the appointments of Dr. Carlos Bais as CSO and David Matly as President [1][2][3][4]. Leadership Changes - Dr. Brendan Eckelman is leaving Inhibrx to become the founder and CEO of a new biotechnology company, with an exclusive license agreement in place for certain technologies previously pursued by Inhibrx [2]. - Dr. Carlos Bais, previously Executive Vice President of Translational Sciences, will take over as CSO, bringing a strong scientific background and expertise in late-stage development [5][6]. - David Matly has been promoted to President while retaining his roles as Chief Commercial and Business Development Officer, overseeing various functions including clinical development and operations [4][5]. Financial and Strategic Implications - The agreement with Dr. Eckelman’s new company includes an upfront payment upon the completion of initial funding and future development milestones, indicating potential financial implications for Inhibrx [2]. - David Matly played a key role in the asset sale of INBRX-101 to Sanofi for up to $2.2 billion in 2024, highlighting his experience in commercial strategy and business development [4]. Company Overview - Inhibrx Biosciences is a clinical-stage biopharmaceutical company focused on developing novel biologic therapeutic candidates, utilizing diverse protein engineering methods [9]. - The current clinical pipeline includes ozekibart (INBRX-109) and INBRX-106, with key data readouts expected in 2025 [9].