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Core Insights - Incyte Corp has raised its annual sales forecast for Jakafi, a blood cancer treatment, due to strong demand that exceeded Wall Street estimates for the third quarter [1] Financial Performance - The company reported robust demand for Jakafi, leading to a positive financial outlook [1] - The updated sales forecast reflects confidence in the drug's market performance [1]

Third Quarter 2025 Financial Results and Business Update 2 Forward looking statements Except for the historical information set forth herein, the matters set forth in this release contain predictions, estimates and other forward-looking statements, including any discussion of the following: Incyte's strategic priorities and its plans for executing on same; Incyte's financial guidance for 2025, including its expectations regarding sales of and demand for Jakafi and Opzelura; expected revenue contribution fro ...

Exhibit 99.1 FOR IMMEDIATE RELEASE Incyte Reports Third Quarter 2025 Financial Results and Provides Business Updates Total revenues of $1.37 billion in the third quarter of 2025, reflecting 20% growth compared to the third quarter of 2024 Jakafi (ruxolitinib) net product revenue of $791 million, an increase of 7% compared to the same period in 2024 ® Opzelura (ruxolitinib) cream net product revenue of $188 million, an increase of 35% compared to the prior year period ® Hematology-Oncology portfolio net prod ...

Core Insights - Incyte has announced new data from the Phase 3b TRuE-AD4 trial of Opzelura® (Ruxolitinib Cream) for adults with moderate atopic dermatitis, indicating positive outcomes in treatment efficacy [1] Group 1: Trial Results - The Phase 3b TRuE-AD4 trial demonstrated significant improvements in the severity of atopic dermatitis among participants using Opzelura® compared to the control group [1] - The data suggests that Opzelura® is effective in reducing the symptoms of moderate atopic dermatitis, which may enhance its market potential [1] Group 2: Market Implications - The positive trial results could lead to increased adoption of Opzelura® in clinical practice, potentially boosting Incyte's revenue from this product line [1] - As the demand for effective treatments for atopic dermatitis grows, Incyte may strengthen its position in the dermatology market [1]

Core Viewpoint - Incyte Corporation (INCY) is expected to exceed expectations in its third-quarter 2025 earnings report, with revenue estimates at $1.26 billion and earnings at $1.66 per share [1]. Group 1: Revenue Drivers - Incyte's primary revenue source is from Jakafi (ruxolitinib) sales in the U.S., with strong sales momentum anticipated across all approved indications [2][5]. - The Zacks Consensus Estimate for Jakafi's third-quarter sales is projected at $770 million, with higher royalties expected from Novartis due to increased Jakavi sales outside the U.S. [3][5]. - Additional revenue contributions are expected from Opzelura, with a sales estimate of $179.1 million, and from other drugs like Minjuvi, Pemazyre, and Iclusig, with respective sales estimates of $37.9 million, $22 million, and $30.6 million [7][10]. Group 2: Recent Developments - Incyte's recent approvals, including Niktimvo and Monjuvi's expanded use, are likely to enhance product sales [5][9]. - The company has entered into an asset purchase agreement with MorphoSys AG, gaining exclusive global rights to tafasitamab, which is expected to boost sales following FDA approval for a new cancer indication [9]. Group 3: Financial Performance - Year-to-date, Incyte's shares have increased by 29.3%, outperforming the industry growth of 9.3% [4]. - Incyte has a mixed earnings surprise history, with two earnings beats and two misses in the last four quarters, averaging a surprise of 4.2% [15]. Group 4: Earnings Expectations - The Earnings ESP for Incyte is +3.48%, indicating a potential earnings beat, with the most accurate estimate at $1.72 compared to the consensus estimate of $1.66 [17].

Core Insights - The BRAVE-AA-PEDS trial is the first and largest study focused on children and adolescents with severe alopecia areata, showing that 71% of adolescents treated with baricitinib 4 mg achieved successful scalp hair regrowth at one year [1][2][4] - Eli Lilly plans to submit the trial data to global regulators for a potential label update for baricitinib, commercially known as Olumiant [1][9][10] Group 1: Trial Results - At one year, 54.1% of patients receiving baricitinib 4 mg and 31% receiving baricitinib 2 mg achieved successful hair regrowth, defined as 80% or more scalp hair coverage [7] - Among patients with severe disease, 71% receiving baricitinib 4 mg and 58.6% receiving baricitinib 2 mg achieved successful hair regrowth [7] - In a post-hoc analysis, 80% of adolescents diagnosed with severe AA less than two years before treatment achieved successful hair regrowth with baricitinib 4 mg [4] Group 2: Safety Profile - The safety profile of baricitinib in adolescents was consistent with that seen in adult trials, with no new safety signals observed after one year [5][8] - Common treatment-emergent adverse events included acne, upper respiratory tract infection, and influenza, with no deaths or major adverse cardiovascular events reported [5][8] Group 3: Future Plans and Context - Lilly intends to enroll a new cohort of children ages 6 to under 12 in the BRAVE-AA-PEDS trial in the next year [9][12] - Baricitinib is the most-researched JAK inhibitor in alopecia areata, with over 1,300 adults and 423 adolescents enrolled in clinical trials [10]

Core Insights - The article emphasizes the focus on growth and momentum stocks that are reasonably priced and expected to outperform the market in the long term [1] - It highlights a significant investment opportunity, noting that the S&P 500 increased by 367% and the Nasdaq by 685% from March 2009 to 2019, indicating a strong recovery from the financial crisis [1] Investment Strategy - The investment approach involves long-term investment in quality stocks, with the use of options as part of the strategy [1] - The article suggests that investors should consider high-quality growth stocks to enhance their investment returns [1] Market Context - The performance data provided serves as a historical context for potential future investments, illustrating the substantial gains that can be achieved in the stock market following a downturn [1]

Core Insights - Incyte Corporation (INCY) is a biopharmaceutical company focused on hematology/oncology, inflammation, and autoimmunity, with a market cap of $16.8 billion, set to announce Q3 earnings on October 28, 2025 [1] Financial Performance - Analysts expect INCY to report a profit of $1.38 per share for Q3 2025, an increase of 89% from $0.73 per share in the same quarter last year [2] - For the full fiscal year, EPS is projected to be $5.14, a significant rise from $0.08 in fiscal 2024, with an expected 25.1% year-over-year increase to $6.43 in fiscal 2026 [3] Stock Performance - INCY stock has increased by 29.8% over the past 52 weeks, outperforming the S&P 500 Index's 14.8% gains and the Health Care Select Sector SPDR Fund's 5.5% losses [4] - The stock's performance is attributed to strong sales of Jakafi and the successful launch of Opzelura cream, along with recent FDA approvals for new treatments [5] Market Sentiment - Analysts maintain a "Moderate Buy" rating for INCY, with 11 out of 26 analysts recommending a "Strong Buy," 14 advising a "Hold," and one suggesting a "Strong Sell" [7] - The current trading price is above the mean price target of $85.67, with a Street-high price target of $115 indicating a potential upside of 33.5% [7]

Core Insights - The company is presenting updates on two solid tumor programs at ESMO 2025, focusing on a TGF-beta receptor II by PD-1 bispecific and a KRAS G12D inhibitor [1] - The presentation includes insights from key team members regarding the biological rationale and future plans for these programs [2] Group 1 - The solid tumor update is being held in Berlin, with both in-person and online attendance [1] - The two programs discussed are the TGF-beta receptor II by PD-1 bispecific and the KRAS G12D inhibitor, with data presented at the event [1] - The agenda includes presentations from the Chief Scientific Officer, Head of Early Development, and Chief Medical Officer, focusing on the biology, data sets, and future plans for the programs [2]