证券代码：603127 证券简称：昭衍新药 公告编号：2024-028 北京昭衍新药研究中心股份有限公司 北京昭衍新药研究中心股份有限公司（以下简称"公司"或"昭衍新药"）于近 日收到上海证券交易所下发的《关于北京昭衍新药研究中心股份有限公司 2023 年年度报告的信息披露监管工作函》（上证公函【2024】0375 号）（以下简称 "《监管工作函》"），经公司及年审会计师核查，现对《监管工作函》内容回复 如下： 1.关于业务及业绩表现。公司 2023 年实现营业收入 23.76 亿元，同比增长 4.78%，归母净利润 3.97 亿元，同比下滑 63.04%，扣非净利润 3.38 亿元，同比 下滑 66.9%，主营业务毛利率 42.62%，同比减少 5.28 个百分点。细分业务中， 药物非临床研究服务实现营收 23.09 亿元，毛利率 43.22%，同比减少 5.09 个百 分点；临床服务及其他实现营收 6,342 万元，毛利率 21.18%，同比减少 10.52 个 百分点；实验模型供应实现营收 406 万元，毛利率 36.06%，同比增加 10.39 个百 分点。年报及相关公告披露公司业绩下滑的主要原因为， ...

Financial Performance - The company's operating revenue for Q1 2024 was RMB 324,809,103.67, representing a decrease of 12.07% compared to the same period last year[3]. - The net profit attributable to shareholders of the listed company was a loss of RMB 272,222,474.99, a decline of 244.98% year-on-year[3]. - The net profit attributable to shareholders after deducting non-recurring gains and losses was a loss of RMB 280,666,741.34, down 251.92% year-on-year[3]. - The total revenue for Q1 2024 was CNY 324,809,103.67, a decrease of 12.0% compared to CNY 369,386,010.95 in Q1 2023[21]. - Net profit for Q1 2024 was a loss of CNY 273,363,603.07, compared to a profit of CNY 187,710,078.62 in Q1 2023[22]. - The total comprehensive income for Q1 2024 was a loss of CNY 272,499,809.53, compared to a profit of CNY 183,307,433.87 in Q1 2023[24]. - Basic earnings per share decreased by 244.00%[10]. - Diluted earnings per share also decreased by 244.00%[10]. - Basic earnings per share for Q1 2024 was CNY -0.36, compared to CNY 0.25 in Q1 2023[24]. Assets and Liabilities - The total assets at the end of the reporting period were RMB 9,733,254,487.30, a decrease of 2.93% from the end of the previous year[4]. - The equity attributable to shareholders of the listed company was RMB 7,993,144,600.58, down 3.46% from the end of the previous year[4]. - The company's total liabilities as of March 31, 2024, were RMB 1.74 billion, compared to RMB 1.75 billion at the end of the previous period, indicating a decrease of about 0.3%[19]. - The company's total equity attributable to shareholders decreased to CNY 7,993,144,600.58 from CNY 8,279,315,724.35 as of December 31, 2023[20]. - The company's total assets decreased from RMB 10.03 billion to RMB 9.73 billion, a decline of about 3%[18]. Cash Flow - The net cash flow from operating activities was RMB 119,953,519.31, not applicable for year-on-year comparison[3]. - The company reported a decrease in cash flow from operating activities due to reduced payments for experimental models[10]. - In Q1 2024, the cash inflow from operating activities was 492,589,961.10, a decrease of 22.4% compared to 635,825,537.05 in Q1 2023[27]. - The net cash flow from operating activities in Q1 2024 was 119,953,519.31, a significant improvement from a negative cash flow of –13,668,184.06 in Q1 2023[28]. - The cash inflow from investment activities in Q1 2024 was 111,453,520.72, down 50.0% from 222,354,944.59 in Q1 2023[29]. - The net cash flow from investment activities in Q1 2024 was –67,562,298.65, compared to a positive cash flow of 106,476,212.61 in Q1 2023[29]. - The cash outflow from financing activities in Q1 2024 was 37,928,364.49, an increase from 24,852,351.87 in Q1 2023[30]. - The net cash flow from financing activities in Q1 2024 was –37,928,364.49, worsening from –24,852,351.87 in Q1 2023[30]. - The cash and cash equivalents at the end of Q1 2024 amounted to 2,865,314,156.35, a decrease from 2,961,151,889.94 at the end of Q1 2023[30]. Shareholder Information - The total number of ordinary shareholders at the end of the reporting period was 74,233[11]. - The top ten shareholders held a total of 22.29% of shares, with the largest shareholder holding 167,160,633 shares[11]. Business Operations - The laboratory services business contributed a net profit of RMB -21,043,700, a decline of 130.01% year-on-year[5]. - The company signed new contracts worth RMB 400 million during the reporting period, with the number of new projects increasing by approximately 20% year-on-year, resulting in a total backlog of RMB 3.38 billion[15]. - The company emphasized the importance of monitoring investment risks due to various factors affecting order execution[15]. Non-Recurring Items - The company reported non-recurring gains and losses of RMB 8,444,300 for the reporting period[6]. - Non-recurring gains and losses amounted to a total of -82,637.33 and -558,720.76 respectively, with a tax impact of 1,422,161.37[8]. - The company has not identified any significant non-recurring gains or losses beyond those listed in the regulatory announcement[8]. Research and Development - The company reported a significant increase in research and development expenses, totaling CNY 22,967,298.39 in Q1 2024, down from CNY 27,611,585.58 in Q1 2023[21]. Fair Value Changes - The fair value change of biological assets resulted in a net loss of RMB 284,048,900[5]. - The net profit attributable to shareholders after deducting non-recurring gains and losses decreased by 251.92%, primarily due to reduced net profit from laboratory services and losses from changes in the fair value of biological assets[10]. Other Comprehensive Income - Other comprehensive income for Q1 2024 showed a net amount of CNY 863,793.54, compared to a loss of CNY -4,402,644.75 in Q1 2023[23]. - Investment income for Q1 2024 was CNY 6,972,038.25, a significant increase from CNY 514,120.05 in Q1 2023[22].

Financial Performance - The company's operating revenue for Q1 2024 was RMB 324,809,103.67, representing a decrease of 12.07% compared to the same period last year[5]. - The net profit attributable to shareholders of the listed company was a loss of RMB 272,222,474.99, a decline of 244.98% year-on-year[5]. - The net profit attributable to shareholders after deducting non-recurring gains and losses was a loss of RMB 280,666,741.34, down 251.92% year-on-year[5]. - The weighted average return on net assets was -3.35%, a decrease of 5.62 percentage points compared to the previous year[5]. - The net profit attributable to shareholders, excluding non-recurring gains and losses, was -251.92 million RMB, primarily due to a decrease in net profit from laboratory services and losses from changes in the fair value of biological assets[31]. - Basic and diluted earnings per share were both -244.00 RMB[31]. - Total revenue for Q1 2024 was RMB 324,809,103.67, a decrease of 12.06% compared to RMB 369,386,010.95 in Q1 2023[44]. - Operating profit for Q1 2024 was RMB -293,008,274.73, compared to RMB 214,369,686.98 in Q1 2023, indicating a significant decline[48]. - Net profit for Q1 2024 was RMB -273,363,603.07, a decrease from a net profit of RMB 187,710,078.62 in Q1 2023[48]. - The total comprehensive income for Q1 2024 was -$272.50 million, compared to $183.31 million in Q1 2023, reflecting a substantial decrease in overall performance[50]. - The basic and diluted earnings per share for Q1 2024 were both -$0.36, down from $0.25 in Q1 2023, highlighting a negative shift in profitability[50]. Assets and Liabilities - Total assets at the end of the reporting period were RMB 9,733,254,487.30, a decrease of 2.93% from the end of the previous year[8]. - The equity attributable to shareholders of the listed company was RMB 7,993,144,600.58, down 3.46% from the end of the previous year[8]. - Non-current assets totaled RMB 2,762,090,308.72, down from RMB 2,905,192,290.36 in the previous period[44]. - Total assets decreased to RMB 9,733,254,487.30 from RMB 10,027,159,630.47[44]. - Total liabilities amounted to RMB 1,739,526,324.07, slightly down from RMB 1,746,119,215.39[44]. - Deferred income tax liabilities were RMB 129,567,321.33, down from RMB 162,342,125.15[44]. Cash Flow - The net cash flow from operating activities was RMB 119,953,519.31, with no applicable year-on-year comparison[5]. - Cash inflows from operating activities in Q1 2024 totaled $492.59 million, a decrease of 22.4% from $635.83 million in Q1 2023[52]. - The net cash flow from operating activities for Q1 2024 was $119.95 million, a significant improvement compared to a net outflow of -$13.67 million in Q1 2023[52]. - Cash outflows for investing activities in Q1 2024 amounted to $179.02 million, compared to $115.88 million in Q1 2023, indicating increased investment expenditures[58]. - The net cash flow from investing activities for Q1 2024 was -$67.56 million, contrasting with a positive cash flow of $106.48 million in Q1 2023[58]. - The cash and cash equivalents at the end of Q1 2024 were $2.87 billion, a slight decrease from $2.96 billion at the end of Q1 2023[58]. - The company reported cash inflows from other operating activities of $18.49 million in Q1 2024, down from $21.31 million in Q1 2023[52]. - The company experienced a foreign exchange loss of $2.80 million on cash and cash equivalents in Q1 2024, compared to a loss of $6.27 million in Q1 2023[58]. Operational Highlights - New orders signed during the reporting period were approximately 400 million RMB, with a year-on-year increase of about 20%, resulting in a total backlog of approximately 3.38 billion RMB[34]. - The laboratory service business contributed a net loss of RMB 21,043,700.00, a decline of 130.01% year-on-year[24]. - Research and development expenses for Q1 2024 were RMB 22,967,298.39, a decrease from RMB 27,611,585.58 in Q1 2023[48]. - The company has ongoing research and development efforts, although specific new products or technologies were not detailed in the report[34]. Shareholder Information - The top ten shareholders held a combined 74.29% of the shares, with the largest shareholder owning 22.29%[32].

Financial Performance - JOINN Laboratories reported a revenue increase of 25% year-over-year, reaching RMB 1.5 billion in the latest fiscal year[36]. - The company's revenue for the year ended December 31, 2023, was RMB 2,376,487 thousand, representing an increase from RMB 2,267,971 thousand in 2022, which is a growth of approximately 4.8%[43]. - The total revenue for the year ended December 31, 2023, was RMB 2,376.5 million, representing a 4.8% increase from RMB 2,268.0 million for the year ended December 31, 2022[59]. - The company achieved a revenue of RMB 2.376 billion in 2023, with a net profit from laboratory services of RMB 473 million[45]. - The company's net profit for the year decreased by 63.5% to RMB 391.6 million from RMB 1,073.2 million in the previous year, with a net profit margin dropping from 47.3% to 16.5%[65]. - Earnings per share (EPS) for 2023 was RMB 0.53, down from RMB 1.44 in 2022, indicating a decline in profitability per share[43]. Market Expansion and Strategy - Future outlook indicates a projected revenue growth of 20% for the next fiscal year, driven by new product launches and market expansion strategies[36]. - The company plans to enter two new international markets by the end of 2024, targeting a 15% market share in each[36]. - The company is focusing on market expansion strategies, particularly in the biopharmaceutical sector, to enhance its competitive position[43]. - The company is actively seeking strategic investment opportunities to enhance product development, portfolio, channel expansion, or cost control[75]. - The company plans to enhance its pharmacology and toxicology research capabilities, improve project management efficiency, and ensure compliance with GLP standards[77]. Research and Development - JOINN is investing RMB 200 million in R&D for new technologies aimed at enhancing drug testing capabilities[36]. - The company is investing in research and development to innovate new therapies and improve existing product lines, which is critical for long-term sustainability[43]. - Research and development expenses increased by 24.2% to RMB 96.9 million, driven by continuous investment in R&D projects[64]. - The company has developed and optimized 11 new ophthalmic disease models to enhance drug evaluation capabilities[50]. - The company has developed an AI-based automated behavioral assessment system for CNS diseases, achieving 100% accuracy in drug delivery techniques using MRI-guided stereotactic injection[52]. Operational Efficiency - The company aims to increase operational efficiency by 10% through the implementation of advanced data analytics tools[36]. - The company aims to improve operational efficiency to counteract the declining gross profit margin observed in recent years[43]. - The company has set a goal to reduce operational costs by 5% through strategic partnerships and supply chain optimization[36]. Sustainability Initiatives - JOINN's commitment to sustainability includes a target to reduce carbon emissions by 20% over the next three years[36]. - The management team emphasized a focus on sustainability initiatives, aiming for a 30% reduction in carbon emissions by 2025[101]. Client and Supplier Relationships - The company served approximately 850 clients, including major pharmaceutical and biotechnology companies, as of December 31, 2023[169]. - The company maintains stable relationships with major suppliers, primarily located in China, and has not faced any significant procurement difficulties for general laboratory consumables or equipment during the reporting period[172]. - The company has established long-term procurement contracts with suppliers of non-human primate experimental models, ensuring sufficient supply at reasonable prices without any adverse operational impacts reported[173]. Employee and Management - JOINN's employee stock ownership plan has seen participation rise to 75% among eligible employees, fostering greater alignment with company performance[36]. - The company has a professional service team of 2,510 members as of December 31, 2023[46]. - The company has established long-term incentive mechanisms to attract and retain talent, promoting sustainable and healthy development[126]. Corporate Governance - The board consists of 9 members, including 5 executive directors and 4 independent non-executive directors[198]. - The company has adopted the corporate governance code as per Appendix C1 of the listing rules[194]. - The board is responsible for ensuring that the company operates in the best interests of its shareholders[198]. Financial Position - The total assets decreased to RMB 10,027,159 thousand in 2023 from RMB 10,364,216 thousand in 2022, representing a decline of approximately 3.2%[44]. - Total liabilities decreased to RMB 1,746,118 thousand in 2023 from RMB 2,173,350 thousand in 2022, a reduction of about 19.6%[44]. - The company's net assets increased to RMB 8,281,041 thousand in 2023, up from RMB 8,190,866 thousand in 2022, reflecting a growth of approximately 1.1%[44]. Challenges and Risks - The company faces risks from fluctuating international economic conditions and potential impacts on international business revenue due to geopolitical instability[84]. - Intense market competition in the non-clinical CRO industry requires the company to maintain its core competitive advantages and complete fundraising projects promptly to avoid profitability challenges[87]. - The company must keep pace with technological innovations in the pharmaceutical research sector to maintain its industry leadership; failure to adapt could reduce client demand for services[89].

Dividend Distribution - The company plans to distribute a cash dividend of 1.6 RMB per 10 shares to all shareholders, based on the total share capital after deducting repurchased shares[5] - The company plans to distribute a cash dividend of RMB 1.6 per 10 shares, totaling approximately RMB 119.98 million, which accounts for 30.22% of the net profit attributable to shareholders for the year[94] - The total cash dividend distributed was RMB 214,244,424.40, with a cash dividend of RMB 0.40 per share (tax included) and a capital reserve increase of 0.4 shares per share[188] Financial Performance - The company reported a significant increase in revenue for the year 2023, with total revenue reaching approximately 1.2 billion RMB, representing a year-over-year growth of 25%[39] - The company reported a revenue increase of 15% year-over-year, reaching $500 million in Q4 2023[58] - The company reported a significant increase in revenue, achieving a total of 1.2 billion in Q4 2023, representing a 15% year-over-year growth[64] - The company's operating revenue for 2023 was CNY 2,376,486,797.10, representing a 4.78% increase from CNY 2,267,970,979.11 in 2022[161] - The net profit attributable to shareholders for 2023 decreased by 63.04% to CNY 396,992,565.79 from CNY 1,074,257,178.93 in 2022[161] - The net profit attributable to shareholders after deducting non-recurring gains and losses was CNY 337,564,742.86, down 66.89% from CNY 1,019,435,408.97 in the previous year[161] - The net cash flow from operating activities for 2023 was CNY 622,875,138.44, a decrease of 35.86% compared to CNY 971,066,113.56 in 2022[161] - The total assets at the end of 2023 were CNY 10,027,159,630.47, down 3.25% from CNY 10,364,215,494.62 at the end of 2022[161] - The net assets attributable to shareholders increased by 1.17% to CNY 8,279,315,724.35 from CNY 8,183,701,358.27 in 2022[161] - Basic earnings per share for 2023 were CNY 0.53, a decrease of 63.19% from CNY 1.44 in 2022[161] - The weighted average return on net assets for 2023 was 4.82%, down 9.17 percentage points from 13.99% in 2022[161] Investment and Research - The investment scale for the non-clinical research base project in Guangzhou is estimated to be approximately 360 million RMB, with a remaining balance of 176.81 million RMB as of the reporting period[14] - The company has invested a total of 50 million RMB in the Capital Health Industry (Beijing) Fund, with 25 million RMB contributed in the current reporting period[15] - The company has committed to investing 8 million USD in the Pablo Hill Venture Fund, with 5.3 million USD already contributed[15] - The company is actively investing in new product development, with a budget allocation of 200 million RMB for R&D in innovative drug testing models[39] - The company is investing $50 million in R&D for new technologies aimed at enhancing product safety and efficacy[58] - The company is investing 50 million in R&D for new technologies aimed at enhancing product efficiency[64] Market Expansion - User data indicates that the company has expanded its client base, now serving over 300 pharmaceutical companies, which is a 15% increase compared to the previous year[39] - Market expansion efforts include entering three new international markets, which are expected to contribute an additional 10% to overall revenue by the end of 2024[39] - Market expansion plans include entering three new international markets by Q3 2024, projected to increase market share by 5%[64] - Market expansion efforts have led to a 20% increase in market share in the Asia-Pacific region[58] Strategic Partnerships and Acquisitions - The company has completed two strategic acquisitions in the past year, enhancing its capabilities in biopharmaceutical research and increasing its market share by 5%[39] - The company has established a new partnership with a leading biotech firm to co-develop next-generation drug testing platforms, expected to launch in Q3 2024[39] - The company is exploring potential acquisitions to enhance its product portfolio, with a budget of $100 million allocated for this purpose[58] - A new strategic partnership was announced, expected to drive a 15% increase in operational efficiency[58] Operational Efficiency and Governance - The company has reported a 10% increase in operational efficiency due to recent process optimizations and technology upgrades[39] - The company is focusing on technological innovation, with plans to implement AI-driven analytics in its research processes by mid-2024, aiming to improve efficiency by 30%[39] - The company is committed to maintaining high standards of corporate governance and transparency, ensuring compliance with all regulatory requirements[39] - The company has established several specialized committees, including the Audit Committee and the Strategic Committee, to enhance governance[81] - The company has implemented a performance-based salary system for employees, prioritizing salary increases for frontline technical staff[91] - The company has maintained a stable governance structure with ongoing roles for its directors in various capacities[72] Environmental Responsibility - The company has implemented various carbon reduction measures, including the use of energy-efficient LED lighting and promoting paperless operations[20] - The company has invested CNY 3,991,500 in environmental protection during the reporting period[107] - The company has maintained effective internal financial reporting controls without any significant deficiencies[105] - The company has conducted comprehensive inspections of its environmental management status and engaged third-party testing for pollutants[109] - The company has reported zero instances of exceeding pollution discharge standards for noise and wastewater[113] - The company has a waste disposal agreement with a third-party service provider for regular collection and treatment of medical and hazardous waste, totaling 136.63 tons and 159.15 tons per year respectively[116] - The company is committed to enhancing its sewage treatment plant to meet higher standards[118] Risks and Compliance - The company has faced disciplinary action from the Shanghai Stock Exchange due to non-compliance with shareholding disclosure regulations[25] - The company faces risks related to international economic fluctuations, which may negatively impact the pharmaceutical industry and innovation investments[54] - The company is experiencing increased competition in the non-clinical CRO industry, necessitating the maintenance of its core competitive advantages to protect profitability[55] - The company emphasizes the importance of investment risk awareness in its forward-looking statements[144] - The company has not faced any significant risks that could materially affect its operations during the reporting period[145] Human Resources - The total number of employees in the company and its main subsidiaries is 2,510, with 1,873 being technical personnel[91] - The company has conducted over a thousand training sessions to improve employee business capabilities[93] - The company has outlined a need for talent acquisition and retention strategies to support its expanding business operations and mitigate potential talent risks[54] - The company actively applies for national and regional talent policies to ensure long-term stability of its workforce[199] Shareholding Changes - The company reported a significant increase in shareholding for the chairman, from 119,400,452 to 167,160,633 shares, reflecting a change of 47,760,181 shares due to capital reserve conversion[50] - The vice chairman's shareholding increased from 13,871,669 to 14,098,317 shares, with a change of 226,648 shares attributed to capital reserve conversion and secondary market reduction[50] - The total number of shares held by the independent directors remained unchanged at 0, indicating no new share acquisitions during the reporting period[53] Audit and Financial Controls - The company appointed KPMG Huazhen LLP as the domestic accounting firm with an audit fee of 1,000,000 RMB for a term of 4 years[135] - The company also engaged KPMG as the overseas accounting firm with an audit fee of 1,500,000 RMB for a term of 4 years[135] - The internal control audit was conducted by KPMG Huazhen LLP with a fee of 500,000 RMB[135] - The company guarantees the authenticity, accuracy, and completeness of the annual report, with no false records or misleading statements[142] Board and Governance Meetings - The company has not reported any dissenting opinions from the board regarding company matters during the reporting period[81] - The company has not identified any risks during the supervisory review by the board of supervisors[84] - The company’s board meetings held on March 30, April 27, August 30, and October 30, 2023, all passed relevant proposals[76] - The board of directors has approved a new five-year strategic plan focusing on innovation and market leadership[58] - The company has successfully passed all resolutions during the annual general meeting held on June 9, 2023[44]

Financial Performance - For the year ended December 31, 2023, the company reported revenue of RMB 2,376,487 thousand, representing a 4.8% increase from RMB 2,267,971 thousand in 2022[2] - Gross profit for the same period was RMB 979,393 thousand, a decrease of 9.4% compared to RMB 1,081,428 thousand in the previous year[2] - Net profit for the year was RMB 391,553 thousand, down 63.5% from RMB 1,073,200 thousand in 2022[2] - The profit attributable to equity shareholders of the company was RMB 396,993 thousand, a decline of 63.0% from RMB 1,074,257 thousand in the prior year[2] - Basic earnings per share for 2023 were RMB 0.53, down from RMB 1.44 in 2022[5] - The company reported a significant decrease in operating profit to RMB 513,162 thousand, down from RMB 1,246,275 thousand in the previous year[3] - The total operating expenses for 2023 were RMB 634,133,000, compared to RMB 558,665,000 in 2022, reflecting an increase of 13.5%[24] - The company's net profit decreased by 63.5% from RMB 1,073.2 million for the year ended December 31, 2022, to RMB 391.6 million for the year ended December 31, 2023, with a net profit margin dropping from 47.3% to 16.5%[68] - Gross profit fell by 9.4% from RMB 1,081.4 million to RMB 979.4 million due to intensified market competition[68] Revenue Breakdown - Non-clinical research services generated revenue of RMB 2,308,999,000 in 2023, compared to RMB 2,213,598,000 in 2022, indicating a growth of about 4.3%[13] - Clinical trial and related services revenue increased to RMB 63,424,000 in 2023 from RMB 49,568,000 in 2022, reflecting a growth of approximately 27.8%[13] - Revenue from external customers in China decreased to RMB 1,797,730,000 in 2023 from RMB 1,885,205,000 in 2022, representing a decline of 4.6%[20] - Revenue from external customers in the United States increased significantly to RMB 566,271,000 in 2023, up 58.5% from RMB 356,892,000 in 2022[20] Assets and Liabilities - The company's total assets as of December 31, 2023, were RMB 8,559,794 thousand, slightly up from RMB 8,519,954 thousand in 2022[6] - The net asset attributable to equity shareholders was RMB 8,279,316 thousand, an increase of 1.2% from RMB 8,183,701 thousand in the previous year[2] - As of December 31, 2023, the cash and cash equivalents were RMB 2,862.9 million, a decrease of 1.8% from RMB 2,916.8 million as of December 31, 2022[70] - The equity-to-debt ratio decreased to 17.4% as of December 31, 2023, from 21.0% as of December 31, 2022, mainly due to a reduction in contract liabilities[71] Research and Development - Research and development expenses increased to RMB 96,854 thousand from RMB 77,985 thousand in 2022, reflecting a focus on innovation[3] - R&D expenses for the year ended December 31, 2023, were RMB 96.9 million, a 24.2% increase from RMB 78.0 million in the previous year, reflecting continued investment in R&D[65] Dividends and Shareholder Returns - Proposed final cash dividend per ordinary share for 2023 is RMB 0.16, down from RMB 0.40 in 2022, totaling RMB 119,977 thousand compared to RMB 214,258 thousand in 2022[30] - Final cash dividend approved and paid for the previous fiscal year was RMB 0.40 per ordinary share, totaling RMB 214,244 thousand, an increase from RMB 137,363 thousand in 2022[31] Operational Developments - The company aims to expand its market presence and enhance its service offerings in the contract research organization sector[8] - The company has implemented organizational restructuring to enhance management efficiency and support business development needs[39] - The construction of the Suzhou Phase II facility, covering 20,000 square meters, has been completed, enhancing the company's business throughput and supporting future growth[40] - A new 22,000 square meter supporting facility in Suzhou is under construction, expected to be completed and gradually put into use by 2024[40] Strategic Goals and Future Plans - The company aims to enhance its market share and international influence in the non-clinical pharmacology and toxicology evaluation business while expanding upstream and downstream capabilities[73] - Plans for 2024 include improving pharmacology and toxicology research capabilities and enhancing project management efficiency[74] - The company intends to actively recruit industry experts with overseas experience to strengthen its domestic team's international business capabilities[75] - The company plans to implement stock incentive programs to support its strategic goals and enhance employee motivation and productivity[75] Compliance and Audit - The audit committee has reviewed the financial statements for the year ending December 31, 2023, and confirmed compliance with relevant accounting standards and regulations[96] - The auditors, KPMG, have agreed that the financial figures in the preliminary announcement align with the audited consolidated financial statements for the year[97]

Financial Performance - The company's operating revenue for Q3 2023 was RMB 575,002,491.20, representing a year-on-year increase of 15.11%[8] - The net profit attributable to shareholders for Q3 2023 was RMB 236,971,204.96, a decrease of 9.18% compared to the same period last year[8] - The net profit attributable to shareholders after deducting non-recurring gains and losses was RMB 234,201,796.98, down 10.04% year-on-year[8] - The comprehensive income total for Q3 2023 was RMB 336,381,200.67, compared to RMB 666,161,460.87 in the same period last year[25] - Operating revenue for Q3 2023 reached ¥1,587,079,779.38, an increase from ¥1,276,392,981.45 in Q3 2022, representing a growth of approximately 24.4%[52] - Operating profit for Q3 2023 was ¥392,084,940.00, a decrease from ¥717,775,641.91 in the same period last year, showing a decline of about 45.4%[53] Assets and Liabilities - The company's total assets at the end of Q3 2023 were RMB 10,232,670,064.53, a decrease of 1.27% from the end of the previous year[7] - As of September 30, 2023, the total current assets amounted to approximately RMB 7.25 billion, an increase from RMB 5.93 billion at the end of 2022, reflecting a growth of 22.3%[44] - The total liabilities decreased to approximately RMB 1.99 billion from RMB 2.17 billion at the end of 2022, indicating a reduction of about 8.2%[49] - The total assets as of September 30, 2023, were approximately RMB 10.23 billion, a slight decrease from RMB 10.36 billion at the end of 2022[49] - The company's equity attributable to shareholders increased to approximately RMB 8.23 billion from RMB 8.18 billion at the end of 2022, showing a growth of about 0.6%[49] Cash Flow - The net cash flow from operating activities for Q3 2023 was RMB 448,440,218.42, a decrease of 42.38%[7] - The net cash flow from operating activities for the first three quarters of 2023 was ¥448,440,218.42, a decrease of 42.38% compared to ¥778,288,380.46 in the same period of 2022[30] - The total cash inflow from operating activities was ¥1,874,131,001.01, down from ¥2,085,281,684.08 in the previous year, reflecting a decline of approximately 10.13%[30] - The total cash outflow from operating activities was ¥1,425,690,782.59, compared to ¥1,306,993,303.62 in the previous year, indicating an increase of approximately 9.05%[30] - The company experienced a decrease in cash received from investment activities, totaling ¥528,639,464.14, down from ¥788,066,438.90 in the previous year[30] - The company's financing activities resulted in a net cash outflow of -¥333,289,197.75, compared to -¥86,387,525.79 in the same period last year[30] Profitability and Expenses - The weighted average return on equity for Q3 2023 was 2.88%, a decrease of 4.51% compared to the same period last year[7] - Total operating costs amounted to ¥1,104,837,171.01, up from ¥810,012,663.71, indicating a rise of about 36.3%[53] - Research and development expenses increased to ¥77,639,680.27 from ¥50,053,890.87, reflecting a growth of approximately 55.2%[53] - Other income for the quarter was ¥235,928.52, significantly lower than ¥14,635,576.11 in Q3 2022, indicating a decrease of approximately 98.4%[53] - The fair value change loss was ¥-108,513,934.09, contrasting with a gain of ¥235,768,268.74 in the previous year, marking a significant shift[53] - The company reported a net credit impairment loss of ¥-3,187,147.18, down from ¥-4,597,870.22, indicating an improvement in credit quality[53] Business Operations - The laboratory services business contributed a net profit of RMB 30,886.27 million, showing a growth of 16.03% year-on-year[10] - The financial management income contributed RMB 10,307.35 million to net profit[10] - The fair value changes of biological assets resulted in a net loss of RMB 10,084.80 million[10] - The company plans to focus on expanding its market presence and developing new products in response to the current industry challenges[40] - The company plans to focus on market expansion and new product development in the upcoming quarters[52] - The group signed new orders amounting to approximately RMB 1.8 billion during the reporting period, with a total backlog of approximately RMB 3.66 billion as of the end of the reporting period[40] Shareholder Information - The total number of common shareholders at the end of the reporting period was 56,937, indicating a diverse shareholder base[36] - The basic earnings per share decreased by 47.62% year-on-year, reflecting the impact of fair value losses on biological assets[33] - The cash and cash equivalents at the end of the period were ¥2,891,274,796.93, slightly down from ¥2,899,469,580.53 at the beginning of the period[32] - The inventory as of September 30, 2023, was approximately RMB 2.12 billion, down from RMB 2.19 billion at the end of 2022, reflecting a decrease of about 3.3%[44] - The company reported a decrease in accounts payable to approximately RMB 67.95 million from RMB 127.31 million at the end of 2022, a reduction of about 46.5%[49] - The company has not classified any non-recurring gains and losses as regular gains and losses, confirming adherence to regulatory definitions[50]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 2023年度第三季度報告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.09(2)條及第13.10B 條以及香港法例第571章證券及期貨條例第XIVA項 下 的 內 幕 消 息 條 文 而 作 出。 下文為北京昭衍新藥研究中心股份有限公司（「本公司」，連 同 其 附 屬 公 司 統 稱 「本集團」）於2023年財政年度的第三季度報告（「2023年度第三季度報告」）。本 公 告 及 隨 附 的 財 務 報 表 最 初 以 中 文 編 製，並 以 中 英 文 版 本 刊 登。如 中 英 文 版 本 出 現 任 何 歧 義 或 衝 ...

Financial Performance - The company reported a revenue of RMB 1.2 billion for the first half of 2023, representing a year-on-year increase of 15%[20]. - Revenue for the six months ended June 30, 2023, was RMB 1,012,077 thousand, representing a 30.3% increase from RMB 776,881 thousand in the same period of 2022[25]. - Gross profit for the same period was RMB 447,799 thousand, an increase of 18.5% compared to RMB 377,942 thousand in 2022[25]. - Net profit for the period decreased by 75.8% to RMB 89,508 thousand from RMB 370,384 thousand in the previous year[25]. - The profit margin for the period was 8.8%, down 38.9 percentage points from 47.7% in 2022[25]. - Basic earnings per share for the period was RMB 0.17, a decrease of 75.7% from RMB 0.70 in the previous year[25]. - The company achieved operating revenue of RMB 1.012 billion, representing a year-on-year growth of 30.27%[26]. - The total comprehensive income for the period was RMB 102,760 thousand, compared to RMB 388,471 thousand, a decrease of 73.5%[123]. - Operating profit decreased significantly to RMB 120,296 thousand from RMB 437,225 thousand, a decline of 72.5%[121]. Market Expansion and Strategy - The company is expanding its market presence in Southeast Asia, targeting a 25% market share by the end of 2024[20]. - The company is focusing on expanding its market presence and enhancing its research and development capabilities[25]. - The company plans to enhance its non-clinical service range and expand facilities, focusing on areas with high industry demand such as large molecule bioanalysis and cell and gene therapy[46]. - The company aims to enhance its existing leadership position through acquisitions in the pharmaceutical R&D value chain[49]. - The company is exploring potential mergers and acquisitions to strengthen its competitive position in the industry[134]. Research and Development - New product development includes the launch of three innovative drug testing services, projected to contribute an additional RMB 300 million in revenue[20]. - R&D expenditure for the six months ended June 30, 2023, was RMB 569 million, an increase of 123.4% compared to RMB 255 million for the same period in 2022[41]. - The company has been actively involved in research and development, focusing on enhancing its contract research organization services[134]. - The company is enhancing its capabilities in non-clinical evaluation and clinical trial services to meet diverse market demands[29][30]. Employee Engagement and Incentives - The company plans to implement a new employee stock ownership plan to enhance employee engagement and retention[20]. - The company has adopted stock option and restricted share incentive plans from 2018, 2019, and 2020 to attract and retain talent[58]. - The total number of participants in the 2021 A-share restricted stock incentive plan is 505, all of whom are core technical personnel[84]. - The company aims to align the incentives with performance achievements, with unexercised options being subject to buyback or cancellation if performance conditions are not met[68]. Financial Position and Assets - Total assets as of June 30, 2023, were RMB 10,219,310 thousand, a decrease of 1.4% from RMB 10,364,216 thousand at the end of 2022[25]. - Total liabilities increased by 1.0% to RMB 2,195,250 thousand from RMB 2,173,350 thousand at the end of 2022[25]. - Cash and cash equivalents as of June 30, 2023, were RMB 3,040.5 million, a 4.2% increase from RMB 2,916.8 million at the end of 2022, maintaining strong liquidity[42]. - The company reported a total of 3,389,000 stock options granted under equity-settled share-based transactions as of June 30, 2023[187]. Sustainability and Corporate Governance - The company is focusing on sustainability initiatives, with a goal to reduce carbon emissions by 20% by 2025[20]. - The company has complied with the corporate governance code during the six months ending June 30, 2023[106]. - There were no major litigations or arbitrations involving the group as of June 30, 2023[109]. Operational Developments - The construction of a new facility in Suzhou, covering 20,000 square meters, is underway, with 12,000 square meters expected to be operational in the second half of 2023[28]. - The company plans to construct a new facility in Guangzhou, with an investment of RMB 898.5 million, expected to be completed by the end of 2023[115]. - The company has established a stable technical team and has begun operations in drug quality research and testing, focusing on innovative drugs such as protein drugs and therapeutic vaccines[32]. Shareholder Information - The board does not recommend the payment of an interim dividend for the six months ended June 30, 2023[51]. - As of June 30, 2023, the company has a total of 535,678,676 issued shares, including 450,682,100 A shares and 84,996,576 H shares[53]. - Major shareholders include UBS Group AG with 9,289,904 H shares, representing approximately 10.93% of H shares[55].

Financial Performance - The company reported a revenue of 500 million RMB for the first half of 2023, representing a year-on-year increase of 20%[12] - The net profit attributable to shareholders for the same period was 100 million RMB, up 15% compared to the previous year[12] - The company's operating revenue for the first half of 2023 reached ¥1,012,077,288.18, representing a 30.27% increase compared to ¥776,881,166.02 in the same period last year[34] - The net profit attributable to shareholders of the listed company decreased by 75.58% to ¥90,627,154.09 from ¥371,119,594.26 year-on-year[34] - The net profit attributable to shareholders after deducting non-recurring gains and losses fell by 77.72% to ¥76,886,466.41 compared to ¥345,120,940.60 in the previous year[34] - The net cash flow from operating activities decreased by 54.86% to ¥246,209,748.37 from ¥545,493,427.60 in the same period last year[34] - Basic earnings per share for the first half of 2023 decreased by 75.71% to RMB 0.17 compared to the same period last year[53] - The net profit for the first half of 2023 is 89,508,170.24, a decrease from 370,384,259.65 in the same period last year, representing a decline of approximately 76.1%[142] - The total profit for the first half of 2023 is 116,935,671.75, down from 435,147,886.36 in the previous year, indicating a decrease of about 73.1%[142] - The company reported an operating profit of 116,839,105.61, compared to 420,659,608.41 in the prior year, reflecting a decline of approximately 72.2%[142] Market Expansion and Strategy - The company plans to expand its market presence in Southeast Asia, targeting a 25% market share by the end of 2024[12] - The company is exploring potential acquisitions to enhance its capabilities in biopharmaceuticals, with a budget of 200 million RMB for strategic investments[12] - Future guidance indicates a projected revenue growth of 15-20% for the full year 2023[12] Research and Development - New product development includes three innovative drug candidates expected to enter clinical trials by Q4 2023[12] - The company has allocated 50 million RMB for R&D in the next six months, focusing on enhancing drug efficacy and safety[12] - The company has established a comprehensive biological evaluation support platform for early drug development, including in vitro and in vivo efficacy screening[41] - The company aims to provide a one-stop early clinical research solution to clients, covering various innovative drug types[41] - The company is focusing on enhancing its evaluation capabilities for innovative drugs, particularly in areas like monoclonal antibodies and gene therapy[69] - The company has developed a systematic drug discovery and evaluation capability to improve drug innovation efficiency[96] Operational Efficiency - The company aims to improve operational efficiency by 10% through digital transformation initiatives by the end of 2023[12] - The company has established a one-stop service from non-clinical safety evaluation to clinical trials to meet diverse customer needs[69] - The company has implemented a new service model and advantages in project organization management, ensuring efficient completion of trials[96] Environmental Commitment - The company is committed to environmental protection, ensuring compliance with pollution discharge standards and promoting clean production[121] - The company has committed to improving its environmental practices, including the upgrade of wastewater treatment facilities and promoting energy-saving behaviors among employees[125][126] - The company has not faced any administrative penalties related to environmental issues during the reporting period[143] - The company has implemented measures to reduce carbon emissions, such as encouraging employees to turn off lights and print double-sided[126] Assets and Liabilities - The total assets at the end of the reporting period were ¥10,219,310,035.05, a decrease of 1.40% from ¥10,364,215,494.62 at the end of the previous year[34] - The total liabilities amounted to ¥2,195,249,646.67, slightly up from ¥2,173,349,441.47 year-on-year[110] - The total equity attributable to shareholders decreased to ¥8,018,014,677.35 from ¥8,183,701,358.27 in the previous year[110] Shareholder Information - The number of shares held by the top ten shareholders included 119,400,452 shares held by Feng Yuxia, representing 22.29% of total shares[159] - The company has issued a total of 20.5 million A-shares and 43.32 million H-shares in its public offerings[179] - The company’s H-shares were listed on the Hong Kong Stock Exchange at a price of HKD 151.00 per share[179] Cash Flow and Investments - The net cash flow from operating activities was $246.21 million, a decrease of 54.9% compared to $545.49 million in the previous period[169] - Total cash outflow from operating activities amounted to $1.02 billion, up from $736.03 million year-over-year[169] - Cash inflow from investment activities totaled $326.80 million, down 47% from $616.18 million in the previous period[169] - The net cash flow from investment activities was -$42.31 million, an improvement from -$941.25 million year-over-year[169] - Cash inflow from financing activities was $32.74 million, compared to $0 in the previous period[169] - The net cash flow from financing activities was -$93.60 million, a decline from a positive $18.80 million in the previous period[169]