Summary of Opthea Limited (OPT) Corporate Update Webcast Company Overview - **Company**: Opthea Limited (OPT) - **Date of Update**: August 19, 2025 - **Context**: The call discusses the results of phase three clinical trials and the company's future direction following disappointing trial outcomes. Key Points Industry and Clinical Trials - **Phase Three Trials**: The company conducted two pivotal trials, COAST and SHORE, comparing its drug sosinibrocept with existing treatments aflibercept (Eylea) and Lucentis [6][10] - **Primary Endpoint Failure**: Both trials did not meet their primary endpoint of demonstrating superior visual acuity improvement at week 52 compared to the control arms [21][22] - **Patient Population**: Approximately 300 patients were enrolled per arm, with baseline characteristics well balanced across different treatment groups [12][13] - **Results**: The control arm showed a 13.75 letter improvement, while the combination therapy with sosinibrocept did not show statistically significant improvement [14][20] - **Safety Profile**: Sosinibrocept was well tolerated, with similar adverse event rates compared to aflibercept and Lucentis, although there was a slight trend for increased inflammation with higher doses of sosinibrocept [18][22] Financial and Development Funding Agreement (DFA) - **DFA Overview**: In August 2022, the company entered a DFA with OSCELET, initially securing $120 million, later amended to a total of $170 million [24][25] - **Settlement with Investors**: Following negative trial results, the company negotiated a settlement with DFA investors, paying $20 million in cash and providing a 9.99% equity stake, terminating the DFA [27][28] - **Current Cash Position**: As of the update, the company has approximately $20 million in cash on hand and no debt [28][32] Future Strategy and Governance - **Streamlining Operations**: The company has reduced its workforce by over 80% and the board of directors by 50% to align with its current scale [26][33] - **Strategic Review**: A comprehensive strategic review will be undertaken over the next several months to assess internal capabilities and potential partnerships [36][62] - **Focus on Shareholder Return**: The board emphasizes maximizing shareholder return as a primary objective in future decisions [36][64] Additional Insights - **Clinical Trial Insights**: The duration of the trials and patient selection may have impacted outcomes, with suggestions that the phase 2b trial's shorter duration might not have fully informed the phase 3 results [43][44] - **Future Opportunities**: The company is exploring potential therapeutic areas beyond ophthalmology, leveraging its scientific knowledge and assets [48][50] - **R&D Tax Credit**: The company plans to submit for an R&D tax credit, which has not yet been received [55] Conclusion - **Outlook**: The company is positioned to navigate its challenges with a focus on governance, operational efficiency, and strategic partnerships, aiming to enhance shareholder value moving forward [36][39][74]

CORPORATE UPDATE INVESTOR CALL – 20 August 2025 Dr Jeremy Levin – Chairman of the Board Fred Guerard – Chief Executive Officer Tom Reilly – Chief Financial Officer For personal use only Important Information This investor presentation (Presentation) is dated August 19th, 2025 and has been prepared by Opthea Limited (ASX:OTP) (Opthea or the Company). SUMMARY INFORMATION This Presentation is for information purposes only and is not a prospectus, disclosure document, product disclosure statement or other offer ...

Core Insights - Optiva Inc. reported its second quarter financial results for the period ending June 30, 2025, highlighting continued growth in bookings and customer acquisition [2][3]. Financial Performance - Revenue for Q2 2025 was $10.3 million, a decrease from $11.4 million in Q2 2024 [11][14]. - Total Contract Value (TCV) bookings for Q2 2025 reached $26.6 million, with a trailing twelve months TCV of $64.3 million [8][9]. - The gross margin for Q2 2025 was 49%, down from 56% in the same period last year, primarily due to lower high-margin support and subscription revenue [14]. - The adjusted EBITDA loss for Q2 2025 was $1.6 million, slightly improved from a loss of $1.7 million in Q2 2024 [11][14]. - The net loss for Q2 2025 was $4.4 million, compared to a net loss of $5.6 million in Q2 2024 [11][14]. Customer Acquisition and Strategic Developments - Optiva secured two new customers in Q2 2025, including a Tier 1 European mobile virtual network operator (MVNO) and a Tier 1 European telecom, bringing the total new customers to 13 over the past two years [3][9]. - A key existing customer, Digitel, renewed its BSS platform support agreement for an additional three years [9]. - Optiva was recognized as a finalist for the Most Innovative Telco AI/ML Product or Solution for the Leading Lights 2025 Awards [10]. Cash Position and Operational Updates - The company ended Q2 2025 with approximately $12.9 million in cash, sufficient to meet working capital commitments for the foreseeable future [5][14]. - Optiva has entered into a 45-day support agreement with 85% of noteholders to negotiate a strategic transaction, with expectations of reaching a binding agreement before the end of the forbearance period [4][19].

Core Viewpoint - Optiva Inc. has entered into a Support Agreement with holders of approximately 85% of its outstanding 9.75% senior secured PIK toggle notes, allowing for a 45-day grace period to negotiate a Potential Transaction [1][2]. Group 1: Support Agreement and Grace Period - The Support Agreement provides a 45-day grace period for Optiva's special committee to negotiate with Noteholders and potential merger partners [2]. - During this grace period, Noteholders have agreed to forbear from exercising their rights related to any payment default on the Notes due July 20, 2025 [2]. Group 2: Financial Position and Operations - Optiva has approximately $12 million in cash as of July 13, 2025, ensuring business continuity and the ability to meet financial commitments [3]. - The company will continue to operate normally, fulfilling commitments to customers, employees, and suppliers during this period [10]. Group 3: Potential Transaction Details - The Potential Transaction involves exchanging the outstanding principal amount of the Notes and accrued interest for a combination of shares and new notes, along with a merger with a strategic third party [4][10]. - Common shareholders of Optiva are expected to receive nominal consideration for their shares in connection with the Potential Transaction [4][10]. Group 4: Repayment and Financial Obligations - The repayment of approximately $108.6 million in principal and $5.2 million in accrued interest due on July 20, 2025, will be addressed as part of the Potential Transaction if reached within the grace period [5]. Group 5: Regulatory and Approval Requirements - Completion of any Potential Transaction will require approval from Optiva's securityholders, court approvals if structured as a plan of arrangement, Toronto Stock Exchange approval, and necessary regulatory approvals [7].

Group 1 - Optiva Inc. announced the election of six new members to its board of directors during the annual meeting of common shareholders [1] - The elected directors include Patrick DiPietro, Lee Matheson, Simon Parmar, Robert Stabile, Barry Symons, and Birgit Troy, with voting results showing a high approval rate ranging from 96.35% to 96.42% [2] - KPMG LLP was re-appointed as the auditor of the Company, with the board authorized to determine the auditor's remuneration [3] Group 2 - Optiva Inc. is a leading provider of cloud-native, AI-powered revenue management software for the telecommunications industry, established in 1999 and listed on the Toronto Stock Exchange [5]

Core Insights - Optiva Inc. has been awarded the MVNOs World award for AI & Analytics Excellence for its BSS Platform, which enhances agility and scalability for MVNEs and MVNOs in the telecom market [1][2] - The platform's cloud-native and AI-driven architecture enables rapid digital onboarding and customer-centric offerings, significantly improving customer acquisition and reducing operational costs [2][3] - Key features such as eSIM enablement and advanced product catalogs allow MVNOs to quickly adapt to market demands, while AI agents provide insights for churn prediction and dynamic pricing [3][4] Company Overview - Optiva Inc. is a leading provider of cloud-native, agentic AI-powered revenue management software for the telecommunications industry, established in 1999 and listed on the Toronto Stock Exchange [6] - The company focuses on maximizing opportunities in digital, 5G, IoT, and emerging markets to drive business success [6] Product Features and Benefits - The Optiva BSS Platform includes AI agents that enhance customer experience through automation, improving resolution times and customer satisfaction [7] - Operational efficiency is increased through proactive management by AI agents, which reduces ticket resolution time and manual efforts [7] - Hyper-personalized engagement is facilitated by sales AI agents, enhancing customer loyalty and sales efficiency [7]

Core Insights - The collaboration among Optiva Inc., PlektonLabs, and Qeema focuses on a TM Forum Open Innovation Catalyst project named INFINITY, aimed at unlocking revenue through dynamic pricing and APIs in the telecommunications sector [2][3][6]. Group 1: Project Overview - The INFINITY project introduces a dynamic pricing solution that allows telecom companies to adapt pricing in real-time based on customer needs and network utilization, thereby creating new revenue streams [3][4]. - The project will be showcased at the DTW25 Ignite event in Copenhagen from June 17-19, 2025 [2][8]. Group 2: Benefits of Dynamic Pricing - Dynamic pricing enables telecom operators to adjust prices based on real-time demand, optimizing network capacity and enhancing customer experience [7]. - The approach allows for monetization of API ecosystems and tailored packages for B2B2C, generating new revenue streams [7][6]. - By leveraging AI and real-time network telemetry, the INFINITY project simplifies API discovery and supports dynamic quote management, facilitating easy monetization and real-time ordering [7][5]. Group 3: Industry Context - The need for dynamic pricing is emphasized as critical in the rapidly evolving telecom landscape, moving operators beyond traditional static pricing models [4]. - The project aims to transform telecom networks from cost centers into agile profit engines by capitalizing on advanced features like network slicing [4][6].

Core Insights - Optiva Inc. reported its first quarter financial results for the period ending March 31, 2025, highlighting a focus on cloud-native billing and revenue management solutions for the telecom industry [2][11]. Business Highlights - Optiva was selected by three existing customers for upgrades and renewals, including a next-generation BSS platform and an Intelligent Network platform upgrade [3][12]. - The company integrated advanced generative AI technology into its BSS and charging solutions, enhancing operational efficiency and customer experience [4][12]. - Optiva's partnership with BT Group was strengthened to implement innovative communication services, leveraging Optiva's latest Application Server [9]. Financial Performance - Revenue for Q1 2025 was $11.6 million, a slight decrease from $11.7 million in Q1 2024 [10][13]. - The company reported a net loss of $2.3 million, an improvement from a net loss of $6.0 million in the same period last year [10][14]. - Adjusted EBITDA for the quarter was $0.5 million, compared to a loss of $2.3 million in Q1 2024 [10][14]. - Gross margin increased to 64% from 58% year-over-year, attributed to higher support and subscription revenue [13]. Cash Position - As of March 31, 2025, Optiva had a cash balance of $8.0 million, down from $12.0 million at the end of Q1 2024 [10][14]. - The company is actively engaged with strategic third parties regarding its $108 million Secured Notes maturing on July 20, 2025, with over 75% of noteholders committed to support [5][6].

Optima Health to acquire Care first, a leading provider of mental health services, for a net consideration of £15,000, adding c.£3.7 million revenue to the GroupAcquisition provides Optima with increased scale in its Mental Health division and will complement its existing Employee Assistance Programme (“EAP”) service offering, bringing over 1,000 new customers, and c.40 employeesAligns with strategy of consolidating margin accretive businesses in areas with significant existing expertise, creating additiona ...

Core Viewpoint - Optima Health plc has announced the acquisition of Cognate Health Limited for a total cash consideration of up to €9 million, which will enhance its geographic reach and service capabilities in the occupational health sector [4][10]. Company Overview - Optima Health is the UK's leading provider of technology-enabled corporate health and wellbeing solutions, with a focus on improving workplace health and safety [4][10]. - Cognate Health Limited is an occupational health services company based in the Republic of Ireland, recognized as a leading provider in the region [8]. Acquisition Details - The acquisition involves the purchase of the entire issued share capital of Cognate Health on a cash-free, debt-free basis, with an initial payment of €7 million and potential earn-out consideration of up to €2 million based on performance [9][11]. - The deal will add approximately €7 million in revenue and €1 million in EBITDA to Optima Health [10]. Strategic Implications - The acquisition will create a base in the Republic of Ireland with around 30 clinic sites and approximately 60 experienced employees, including a network of 35 Occupational Health Physicians [5][10]. - This move aligns with Optima Health's strategic focus on expanding its presence in the occupational health sector and enhancing its ability to service multinational clients [6][8]. Growth Opportunities - The Board of Optima Health believes there are significant opportunities for growth and plans to continue evaluating further acquisitions and consolidation in the market [7][8].