Core Viewpoint - Theralase Technologies Inc. has demonstrated that its lead compound Rutherrin®, when combined with Metformin and radiation, effectively destroys Non-Hodgkin's Lymphoma (NHL) in an animal model, indicating potential for improved cancer treatment options [1][2][3]. Company Overview - Theralase Technologies Inc. is a clinical stage pharmaceutical company focused on the research and development of light, radiation, sound, and drug-activated small molecules for the treatment of various cancers, bacteria, and viruses [1][8]. - Rutherrin® is currently under development for intravenous administration to treat multiple cancers, including brain, lung, pancreatic, and muscle invasive bladder cancer [2][8]. Industry Context - Non-Hodgkin's Lymphoma is ranked as the 5th to 9th most common cancer globally, with an estimated 544,000 new cases and 260,000 deaths in 2020 [2]. - The global market for NHL is projected to reach $16.5 billion by 2031, highlighting significant commercial potential for effective treatments [2][8]. Research Findings - In a study, mice inoculated with A20 mouse lymphoma cells were treated with Rutherrin®, Metformin, and radiation over three weeks, leading to significant tumor destruction and improved survival rates [3][7]. - The combination of Rutherrin®, Metformin, and radiation resulted in the best overall response, including one case of complete tumor regression [5][7]. - Future studies will explore the effectiveness of this trimodal therapy on various cancerous tumors, potentially leading to novel therapeutic options [7].

Core Insights - Graphene Manufacturing Group Ltd. (GMG) has announced the successful multi-year performance testing results of its G® Lubricant, a graphene-based liquid concentrate additive aimed at enhancing diesel and gasoline engine performance, potentially transforming the global liquid fuels industry [1][3][10] Group 1: Product Performance - G® Lubricant has demonstrated an increase in fuel efficiency of up to 8.4% in diesel engines, with only about 1:10,000 of the final lubricant being graphene [3][10] - The product has undergone four years of environmentally controlled testing, verified by The University of Queensland, showing consistent fuel savings in real-world applications [3][7] - The lubricant works by reducing friction in engine components, particularly in the piston area, where approximately 60% of engine friction occurs [21][10] Group 2: Market Potential - The global diesel fuel market is valued at approximately US$1.4 trillion annually, with GMG targeting this market for G® Lubricant, focusing initially on B2B applications [11][12] - GMG estimates that the potential market for G® Lubricant could yield annual revenues of around US$1.2 billion, based on a conservative estimate of 10% of fuel savings realized by users [12][11] - The company plans to initiate a direct marketing campaign targeting fleet owners starting in April 2025, beginning in Australia and expanding to other markets [2][10] Group 3: Commercialization and Development - GMG is preparing packaging and marketing materials for G® Lubricant and aims to commercialize the product following extensive testing [2][10] - The company has submitted a patent application for G® Lubricant, which is currently progressing through the approval process [24][10] - GMG's broader focus includes developing energy-saving products and next-generation battery technologies, leveraging its proprietary graphene production process [25][26]

Ryder System, Inc. (R) reported fourth-quarter 2024 earnings per share (EPS) of $3.45, which surpassed the Zacks Consensus Estimate of $3.42 and improved 16.9% year over year, reflecting higher earnings across all business segments. Find the latest EPS estimates and surprises on ZacksEarnings Calendar.Total revenues of $3.18 billion lagged the Zacks Consensus Estimate of $3.36 billion. The top line improved 5.5% year over year. Operating revenues of $2.61 million grew 7% year over year, reflecting recent ac ...

Revenue Breakdown - Ryder's Fleet Management Solutions (FMS) generated 39% of consolidated revenue in 2024[21] - Supply Chain Solutions (SCS) accounted for 42% of consolidated revenue in 2024, with 832 customer accounts and 291 warehouses[38] - In 2024, ChoiceLease revenue represented 59% of total FMS revenue, while commercial rental and SelectCare accounted for 17% and 11% respectively[24][29] - The DTS business accounted for 19% of consolidated revenue as of December 31, 2024, with 231 customer accounts in the U.S.[51] Acquisitions and Market Position - Ryder acquired Cardinal Logistics in 2024, enhancing scale and network density in dedicated transportation services[16] - The U.S. commercial fleet market is estimated at 10 million vehicles, with a growing trend towards outsourcing logistics and transportation services[19] - The outsourced U.S. dedicated market is estimated at $30 billion from an addressable market of approximately $660 billion[50] Operational Insights - Logistics spending in North America was approximately $2.9 trillion in 2024, with $369 billion outsourced, indicating a strong demand for supply chain solutions[37] - Ryder's used vehicle inventory stood at 9,000 vehicles as of December 31, 2024, aligning with the long-term target range of 7,000 to 9,000[32] - The company operates 563 locations in the U.S. and 27 in Canada, providing maintenance and support services across various industries[22][23] Strategic Focus - Ryder's strategy focuses on operational excellence, customer-centric innovation, and improving full-cycle returns to drive long-term profitable growth[15] - The company aims to drive long-term profitable growth through operational excellence and customer-centric innovation[15] - Ryder's balanced growth strategy includes organic growth, targeted acquisitions, and returning capital to shareholders[20] Service Offerings - The FMS business offers a digital fleet management platform, RyderGyde™, enhancing customer fleet management capabilities[27] - The FMS business offers a variety of fleet solutions to improve customer efficiency and lower costs[18] - In 2024, distribution management and value-added services accounted for approximately 34% of SCS revenue[41] - Dedicated transportation services contributed approximately 30% to SCS revenue in 2024[43] - Transportation management solutions represented 12% of SCS revenue, with $10.4 billion in freight moves executed on behalf of customers, including $328 million in brokerage services[44] - E-commerce and last mile services accounted for 17% of SCS revenue in 2024[45] - Contract manufacturing and contract packaging services made up 7% of SCS revenue in 2024[46] Workforce and Culture - Approximately 50,700 full-time employees were employed in North America as of December 31, 2024, including 13,400 professional drivers[66] - The company emphasizes a high-performance culture and invests in employee development through various training programs and resources[62][64] - The company has established a robust talent and succession planning process to identify and develop critical roles within the organization[63] Safety and Compliance - Safety is a core value for the company, with a dedicated safety organization overseeing safety policies, training, and compliance activities[67][68] - The company utilizes vehicle safety systems and provides ongoing training for drivers and technicians to enhance safety performance[68] - The company’s safety policies require all employees to incorporate safe processes in their operations, with monthly safety scorecards tracked for progress[69] - Ryder Fleet Risk Services provides safety support to customers, helping them navigate industry complexities through customized solutions[70] Economic Resilience - The company focuses on diversifying its contractual business mix to mitigate the impact of economic downturns[55] - The company aims to drive fleet growth through sales and marketing initiatives, operational efficiencies, and innovative products[34] - The company actively monitors and shifts resources to mitigate seasonal effects in its SCS business, which is impacted by customers operating in seasonal industries[58] - Commercial rental operations typically generate the lowest revenue in the first quarter due to lower market demand, with the highest revenue occurring in the third and fourth quarters[57] Regulatory Environment - The company is subject to various regulations from federal, state, and local entities, including the Department of Transportation and the Occupational Safety and Health Administration, which may impose new or more restrictive regulations[59][60]

Financial Data and Key Metrics Changes - The company reported comparable earnings per share of $12 for 2024, significantly above the $5.95 per share generated in 2018 prior to the business transformation [11][19] - Operating revenue grew 8% year-over-year, reflecting the cargo and IFS acquisitions [12] - Return on equity (ROE) was 16%, in line with expectations for an extended freight cycle downturn, and above the 13% generated during the prior cycle peak [11][20] Business Line Data and Key Metrics Changes - Fleet Management Solutions (FMS) operating revenue increased 3%, with pre-tax earnings of $152 million, primarily due to higher ChoiceLease performance [24][25] - Supply Chain Solutions (SCS) operating revenue increased 4%, with earnings up 58% year-over-year, driven by stronger omnichannel retail performance [29] - Dedicated Transportation Solutions (DTS) operating revenue increased 46%, reflecting the acquisition of Cardinal Logistics, with EBT as a percent of operating revenue at 7.1% for the quarter [30][32] Market Data and Key Metrics Changes - The company noted that 61% of 2024 revenue came from asset-light businesses compared to 44% in 2018, indicating a shift in revenue mix towards supply chain and dedicated services [19] - Operating cash flow increased 32% from $1.7 billion in 2018 to $2.3 billion in 2024, reflecting profitable growth in contractual lease, dedicated, and supply chain businesses [20] Company Strategy and Development Direction - The current phase of the balanced growth strategy focuses on operational excellence, customer-centric innovation, and generating profitable growth [15] - The company aims to continue executing its strategy while positioning itself for a cycle upturn, expecting to enhance full-cycle returns [15][49] - The company returned $456 million in cash to shareholders through share repurchases and dividends during 2024 [16] Management's Comments on Operating Environment and Future Outlook - Management expects a muted growth environment in 2025, reflecting freight market conditions, with operating revenue expected to grow approximately 2% [42][45] - The company anticipates typical seasonal patterns in rental demand and a modest improvement later in the year [43] - Management expressed confidence in the strength of the contractual portfolio and ongoing execution of strategic initiatives to drive earnings growth [49][52] Other Important Information - The company completed the acquisition of Cardinal Logistics on February 1, 2024, and IFS on November 1, 2023, enhancing its capabilities in dedicated transportation and supply chain solutions [13] - The company expects to generate approximately $10 billion from operating cash flow and used vehicle sales proceeds over the next three years, creating $3.5 billion of incremental debt capacity [38][39] Q&A Session Summary Question: Revenue growth guidance and moving parts - Management expects mid-single-digit growth in FMS, with continued softness in the freight market impacting overall growth [68][69] Question: Dynamics in FMS and rental demand - Management noted no significant upturn yet, with lease miles remaining flat and used vehicle pricing showing single-digit declines [75][79] Question: Supply chain and dedicated revenue outlook - Management indicated that secular trends favor outsourcing, but the freight market slowdown is impacting growth in dedicated and supply chain segments [88][90] Question: Impact of tariffs and trade policy - Management highlighted that uncertainty around tariffs creates headwinds for long-term contracts but expressed confidence in navigating these challenges [112][113] Question: Dedicated revenue per truck and margin recovery - Management explained that seasonal slowdowns and customer mix adjustments are affecting revenue per truck, with expectations for margin recovery through the integration of Cardinal [102][106]

Fourth Quarter 2024 Earnings Conference Call February 12, 2025 Safe Harbor and Non-GAAP Financial Measures Note Regarding Forward-Looking Statements: Certain statements and information included in this presentation are "forward-looking statements" under the Federal Private Securities Litigation Reform Act of 1995, including: our forecast; our outlook; our expectations regarding market trends and economic environment, such as rental demand, economic growth, challenging freight environment, weakening used veh ...

Ryder (R) reported $3.19 billion in revenue for the quarter ended December 2024, representing a year-over-year increase of 5.5%. EPS of $3.45 for the same period compares to $2.95 a year ago.The reported revenue represents a surprise of -5.13% over the Zacks Consensus Estimate of $3.36 billion. With the consensus EPS estimate being $3.42, the EPS surprise was +0.88%.While investors scrutinize revenue and earnings changes year-over-year and how they compare with Wall Street expectations to determine their ne ...

Ryder (R) came out with quarterly earnings of $3.45 per share, beating the Zacks Consensus Estimate of $3.42 per share. This compares to earnings of $2.95 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 0.88%. A quarter ago, it was expected that this truck leasing company would post earnings of $3.39 per share when it actually produced earnings of $3.44, delivering a surprise of 1.47%.Over the last four quarters, the company h ...

News Release Ryder Reports Fourth Quarter 2024 Results and Provides 2025 Outlook Balanced Growth Strategy Delivers Earnings Growth in all Business Segments Fourth Quarter 2024 Highlights Full-Year 2024 Highlights Full-Year 2025 Forecast MIAMI, February 12, 2025 – Ryder System, Inc. (NYSE: R) reported results for the three months ended December 31 as follows: | | | | | | | | | Diluted | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | Earnings | | | | | | | Earnings | | | (In millions, exc ...

Ryder System, Inc. (R) is scheduled to report fourth-quarter 2024 results on Feb. 12, before market open.See the Zacks Earnings Calendar to stay ahead of market-making news.Ryder has an impressive earnings surprise history. The company's earnings outpaced the Zacks Consensus Estimate in each of the trailing four quarters, delivering an average surprise of 11.3%.The Zacks Consensus Estimate for R’s soon-to-be-reported quarter’s earnings has been revised downward by 0.6% in the past 60 days to $3.42 per share ...