Performance Overview - The Jot ETF has achieved a 69% increase since its launch five years ago [1][2] - The ETF's performance is attributed to various momentum factors and its strategic usage as a core investment [2] Market Insights - Current market conditions are characterized by volatility, leading to a cautious outlook [3] - United Healthcare is highlighted as a safer investment option amidst market uncertainty [3] - There is an expectation of government-level resolutions in the healthcare sector, which could act as a catalyst for market movements [4] Notable Stocks - Monster Beverage is mentioned as a significant player within the consumer staples sector [4]

Core Insights - Thermo Fisher Scientific has launched the CorEvitas Myasthenia Gravis (MG) Registry to collect real-world data on MG patients in the U.S. to evaluate therapies and improve patient care [1][4] Company Overview - Thermo Fisher Scientific is a leading company in the scientific services sector, with annual revenues exceeding $40 billion [6][12] - The company employs around 100,000 people and operates under various well-known brands [7][14] Registry Details - The CorEvitas MG Registry aims to gather clinical data from patients diagnosed with both ocular and generalized forms of MG, tracking disease progression and treatment effectiveness [4][5] - The registry is now active in the U.S., with the first patient enrolled on November 10 [3] Disease Context - Myasthenia Gravis is a rare autoimmune disorder affecting muscle strength, with over 70,000 diagnosed cases in the U.S. [2] - Symptoms can range from mild to severe, including periods of remission and severe episodes requiring medical intervention [2] Research and Development - The registry will support long-term data collection for regulatory-grade research, enhancing understanding of MG and its treatment [4][5] - The initiative is guided by experts from the University of North Carolina and the University of Miami [4]

Stock Recommendations - Chem is still oversold, trading at 15 times earnings with a 5% yield [1] - Thermo Fisher (TMO) is driving the healthcare sector move and could break out above $600 [1] - Web Tech is an infrastructure play related to rails and rapid transit, selling below market multiple [1] - Berkshire Hathaway is on the upswing following Wall Street commentary [2] Market Overview - The Dow Jones Industrial Average is down approximately 500 points [2] - The market is showing a lot of red, indicating a down day [2]

Market Overview - The market is experiencing significant selling pressure despite the end of the government shutdown, indicating a "buy the rumor, sell the news" scenario [2][3] - There is a rotation in the market, with certain sectors like healthcare and industrials showing renewed strength while high-flying stocks are losing momentum as 2025 approaches [4][5] Stock Picks Thermo Fisher Scientific - This diagnostic research company has shown upward momentum, increasing by 38% over the last six months, and is expected to maintain this trend [8][7] - The suggested trade involves buying the stock and writing a call option for January, aiming to capture potential upside [15] Danaher Corporation - Danaher is also a diagnostics company that has shown resilience, with a nearly 10% increase in the last month, and is expected to continue its upward trajectory [17][15] - The trade example is a defined risk call spread to capture upside while managing risk in case of market weakness [16] Valero Energy - Valero, involved in oil and gas refining and renewable energy, has maintained upward momentum despite challenges in the broader energy sector, with a year-to-date increase of 48% [27][28] - The trade example is a risk reversal strategy, selling a 170 put and buying a 190 call for January, allowing for potential upside capture while providing a buffer against downside risk [35][36]

Core Insights - Thermo Fisher Scientific Inc. (TMO) is a leading provider of life sciences solutions, analytical instruments, specialty diagnostics, and laboratory products, with a market cap of $220.3 billion [1] Performance Overview - TMO shares have underperformed compared to the broader market, gaining 8.7% over the past year, while the S&P 500 Index has increased by nearly 14.5% [2] - In 2025, TMO stock is up 13%, compared to the S&P 500's 16.5% rise year-to-date [2] Sector Comparison - TMO has outperformed the Health Care Select Sector SPDR Fund (XLV), which gained about 3.8% over the past year, and TMO's year-to-date gains surpass the ETF's 11.1% returns [3] Market Challenges - TMO's underperformance is attributed to economic weakness in China, pricing pressures, and cautious spending by academic institutions and governments [4] - Diagnostics in China are struggling, while Europe shows modest improvement, and the U.S. market remains stable but uncertain [4] Financial Performance - On October 22, TMO reported Q3 results, with an adjusted EPS of $5.79, exceeding Wall Street expectations of $5.50, and revenue of $11.1 billion, beating forecasts of $10.9 billion [5] - For the current fiscal year ending in December, analysts expect TMO's EPS to grow by 4% to $22.74 on a diluted basis [5] - TMO has a strong earnings surprise history, beating consensus estimates in each of the last four quarters [5] Analyst Ratings - Among 23 analysts covering TMO, the consensus rating is a "Strong Buy," with 16 "Strong Buy" ratings, two "Moderate Buys," and five "Holds" [6] - This rating configuration is less bullish than a month ago, when 17 analysts suggested a "Strong Buy" [7]

Core Points - Thermo Fisher Scientific Inc. has authorized a share repurchase program of $5 billion for its common stock [1] - The share repurchase can occur in the open market or through negotiated transactions [1] - There is no expiration date for the share repurchase authorization [1] - Thermo Fisher Scientific reported annual revenue of approximately $40 billion [1]

Core Insights - Diamond Hill Capital's "Large Cap Fund" underperformed the Russell 1000 Value Index in Q3 2025 despite a market rally, with the Russell 3000 Index gaining 8% and calendar-year returns exceeding 14% [1] Company Highlights - Thermo Fisher Scientific Inc. (NYSE:TMO) was highlighted in the investor letter, showing a one-month return of 6.16% and a 52-week gain of 2.11%, with a closing stock price of $567.64 and a market capitalization of $213.267 billion as of November 5, 2025 [2] - The company reported a revenue growth of 3% in Q2, reaching $10.85 billion, and is ranked 26th among the 30 Most Popular Stocks Among Hedge Funds, with 117 hedge fund portfolios holding its stock at the end of Q2 2025 [4] - Diamond Hill Capital initiated four new positions in Q3 2025, including Thermo Fisher Scientific Inc., indicating a belief that its stock price does not reflect its long-term growth potential [3]

Core Viewpoint - Baron Health Care Fund's performance in Q3 2025 was a 5.39% increase, slightly outperforming the Russell 3000 Health Care Index's 5.05% gain, but lagging behind the broader Russell 3000 Index's 8.18% increase, primarily due to stock selection offset by negative impacts from sub-industry allocations and cash holdings during a rising market [1] Group 1: Fund Performance - The Baron Health Care Fund rose 5.39% in Q3 2025 compared to a 5.05% gain for its benchmark [1] - The fund's performance was similar to the benchmark, with solid stock selection being offset by negative effects from active sub-industry allocations and cash holdings [1] Group 2: Thermo Fisher Scientific Inc. (NYSE:TMO) - Thermo Fisher Scientific Inc. is highlighted as a key stock in the fund's portfolio, with a one-month return of 4.31% and a 52-week gain of 2.15% [2] - As of October 31, 2025, Thermo Fisher's stock closed at $567.39, with a market capitalization of $214.253 billion [2] - The fund added to its position in Thermo Fisher, which is expected to achieve 3% to 6% organic revenue growth in 2026 and 2027, with potential for mid-to-high single-digit adjusted operating income growth [3] - Management anticipates that beyond 2027, Thermo Fisher could deliver over 7% organic revenue growth due to positive long-term drivers in the life sciences tools industry [3] - Thermo Fisher Scientific's revenue grew 3% to $10.85 billion in Q2 2025, and it ranks 26th among the 30 most popular stocks among hedge funds, with 117 hedge fund portfolios holding its shares [4]

Core Viewpoint - Thermo Fisher Scientific announced the acquisition of Clario for $8.875 billion, aiming to enhance its position in the life sciences sector and provide comprehensive solutions from laboratory to clinical settings [2]. Group 1: Industry Acquisition Landscape - The global scientific instrument industry has seen a surge in mergers and acquisitions, with major players acquiring key technologies for market expansion [3]. - Notable acquisitions include: - AMETEK acquiring FARO Technologies for $920 million to enhance precision measurement products [3]. - BD acquiring Edward's critical care division for $4.2 billion to expand its medical monitoring product line [3]. - Thermo Fisher Scientific's acquisition of Clario for $8.875 billion to strengthen its digital clinical capabilities [4]. Group 2: Strategic Directions of Acquisitions - Companies are focusing on technology integration and innovation acceleration through mergers, creating a cycle of "technology acquisition - integration - innovation - market expansion" [5]. - The life sciences sector is projected to reach a market size of $85 billion by 2028, with increasing demand for products like gene sequencers and PCR instruments [6]. - Semiconductor technology is becoming a hot topic for acquisitions, driven by geopolitical factors and the recovery of the global semiconductor industry [6]. - Digitalization and AI integration are key trends, with smart laboratory management systems improving efficiency by over 30% [6]. - Vertical integration and ecosystem building are strategies employed by leading companies like Danaher and Thermo Fisher to enhance supply chain security and customer loyalty [6]. Group 3: Emerging Trends and Market Directions - The shift from single equipment sales to system solutions and the transition from traditional technologies to intelligent and interdisciplinary integration are evident in the industry [7]. - Chinese domestic instrument companies are increasingly engaging in overseas acquisitions, marking a shift from price competition to a "domestic substitution + overseas acquisition" strategy [8]. - The capital market activity in the scientific instrument sector indicates a thriving industry, with AI-driven automation and emerging technologies like quantum sensing and MEMS leading product transformation [9]. - Future hot areas in the scientific instrument industry include life sciences and healthcare, semiconductors and high-end manufacturing, and environmental sustainability [9].

Core Viewpoint - Thermo Fisher Scientific is acquiring Clario Holdings for $8.875 billion in cash, which is expected to enhance its digital and data capabilities in clinical research and drug development [1][3]. Group 1: Acquisition Details - The acquisition deal includes potential future earnouts and performance-based payments, with an initial cash payment at closing and additional payments scheduled for January 2027 and tied to performance results in 2026-2027 [1][4]. - Clario's platform has been instrumental in approximately 70% of FDA drug approvals over the past decade and is projected to generate around $1.25 billion in revenue for 2025 [2]. Group 2: Financial Impact - The acquisition is expected to be immediately accretive, adding 45 cents per share to adjusted EPS in the first year after closing and contributing around $175 million to adjusted operating income by year five [5]. - The company anticipates high single-digit growth for the acquired business and expects to realize $175 million in synergies by year five [5]. Group 3: Recent Earnings Performance - Thermo Fisher reported third-quarter 2025 sales of $11.12 billion, exceeding analyst expectations, and adjusted EPS of $5.79, also above consensus estimates [6]. - The company has raised its 2025 sales guidance to $44.1 billion-$44.5 billion, up from previous guidance, and expects annual profit per share to be in the range of $22.60-$22.86 [7].