Group 1 - The stock selection process showed positive momentum in December, with an average gain of 0.83% for the selected 15 stocks [1] - The SPDR® S&P 500® ETF was mentioned as a benchmark for performance comparison [1] Group 2 - The analyst holds long positions in various companies, including ZTS, MSCI, DPZ, and others, through stock ownership, options, or derivatives [2] - The article reflects the analyst's personal opinions and is not influenced by compensation from any company mentioned [2]

Core Insights - Thermo Fisher Scientific (TMO) is currently not meeting its growth expectations, leading to a cautious outlook due to modest organic growth, high leverage, and premium valuations based on historical performance [1]. Group 1 - The company has been experiencing a more modest pace of organic growth, which raises concerns about its future performance [1]. - High leverage levels are a significant factor contributing to the cautious stance on the company's financial health [1]. - The premium valuations of Thermo Fisher Scientific, based on its past track record, are seen as unsustainable under current growth conditions [1].

Core Insights - Bristol Gate Capital Partners' Q3 2025 investor letter indicates that the US Equity Strategy underperformed the S&P 500® Total Return Index this quarter, primarily due to limited exposure to the AI/TMT and Value sectors, which benefited from the Federal Reserve's rate cut [1] - Despite the underperformance, the portfolio achieved a 15% dividend growth over the trailing 12 months, supported by strong underlying fundamentals [1] Company Highlights - Thermo Fisher Scientific Inc. (NYSE:TMO) is highlighted as a key stock, with a one-month return of 0.53% and a 12.15% increase in share value over the last 52 weeks, closing at $583.45 per share on December 30, 2025, with a market capitalization of $219.207 billion [2] - The company reported Q2 2025 revenue of $10.85 billion, exceeding the consensus estimate of $10.68 billion, and earnings per share of $5.36, surpassing the estimate of $5.22 [3] - Thermo Fisher's stock price increased by 9% following the positive earnings release on July 23, driven by 2% organic growth and the maintenance of long-term guidance [3] Investment Sentiment - Thermo Fisher Scientific Inc. ranks 26th among the 30 Most Popular Stocks Among Hedge Funds, with 121 hedge fund portfolios holding the stock at the end of Q3, an increase from 117 in the previous quarter [4] - While acknowledging Thermo Fisher's potential, there is a belief that certain AI stocks may offer greater upside potential and lower downside risk [4]

Core Viewpoint - Thermo Fisher Scientific Inc. is positioned for growth with a focus on biopharma recovery and strategic acquisitions, enhancing its clinical trial research capabilities [2][3][4]. Group 1: Financial Outlook - Bank of America raised the price target for Thermo Fisher from $650 to $700, maintaining a Buy rating, anticipating a recovery in biopharma spending by 2026 [2]. - The firm expects current market headwinds to ease, leading to a return to normal conditions [2]. Group 2: Strategic Acquisitions - Thermo Fisher announced the acquisition of Clario for up to $9.4 billion, which includes an upfront payment of approximately $8.88 billion and potential earn-out payments based on Clario's performance [3]. - This acquisition is part of Thermo Fisher's strategy to strengthen its clinical trial research business amid increasing demand in the US [3][4]. - The deal marks Thermo Fisher's third major acquisition in the year, reflecting its commitment to capitalize on the expanding drug development and manufacturing activities in the pharmaceutical sector [3]. Group 3: Market Positioning - The acquisition of Clario positions Thermo Fisher deeper into clinical development, which is viewed as a more stable and attractive growth area compared to early-stage research [4]. - Thermo Fisher operates as a global supplier of analytical instruments, clinical development solutions, specialty diagnostics, and various services in the laboratory, pharmaceutical, and biotechnology sectors [4].

Core Insights - Thermo Fisher Scientific Inc. (TMO) is a leading provider of life sciences solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services, with a market cap of $218.2 billion [1] Financial Performance Expectations - Analysts expect TMO to report a profit of $6.44 per share for Q4 2025, reflecting a 5.6% increase from $6.10 per share in the same quarter last year [2] - For the full fiscal year 2025, TMO's EPS is projected to be $22.74, up 4% from $21.86 in fiscal 2024, and is expected to rise to $24.56 in fiscal 2026, an 8% year-over-year increase [3] Stock Performance - TMO stock has underperformed the S&P 500 Index, which gained 15.7% over the past 52 weeks, with TMO shares increasing by only 11.2% during the same period [4] - The stock also lagged behind the Health Care Select Sector SPDR Fund's 12.1% returns in the same timeframe [4] Market Challenges - The underperformance of TMO is attributed to weaknesses in China, pricing pressures, and cautious spending from academic and government sectors, with diagnostics in China still struggling [5] - While Europe shows modest improvement and the U.S. market remains stable but uncertain, these factors have impacted TMO's growth [5] Recent Earnings Report - On October 22, TMO shares rose by 1.7% following the release of Q3 results, where the adjusted EPS of $5.79 exceeded Wall Street's expectations of $5.50, and revenue reached $11.1 billion, surpassing the forecast of $10.9 billion [5] Analyst Ratings - The consensus opinion among analysts on TMO stock is bullish, with a "Strong Buy" rating from 18 out of 23 analysts, while two suggest a "Moderate Buy" and three give a "Hold" rating [6] - The average analyst price target for TMO is $636.90, indicating a potential upside of 8.9% from current levels [6]

Core Insights - The Artisan Value Fund's third-quarter 2025 performance was positive, with returns of 0.83% for Investor Class ARTLX, 0.91% for Advisor Class APDLX, and 0.90% for Institutional Class APHLX, compared to a 5.33% return for the Russell 1000 Value Index [1] Group 1: Market Context - The equity market rally continued in Q3 2025, driven by strong corporate earnings, increased AI investment, and expectations of economic support from US fiscal policy and lower interest rates [1] Group 2: Company Focus - Thermo Fisher Scientific Inc. - Thermo Fisher Scientific Inc. (NYSE:TMO) is highlighted as a key stock, providing life sciences solutions, analytical instruments, specialty diagnostics, laboratory products, and biopharma services [2] - The stock experienced a one-month return of -0.75% but gained 11.93% over the last 52 weeks, closing at $580.74 per share on December 26, 2025, with a market capitalization of $218.19 billion [2] - Thermo Fisher was one of the top contributors to returns in Q3, alongside Lam Research and ASML, following purchases made during a market downturn [3]

Core Viewpoint - Thermo Fisher Scientific Inc. will release its financial results for Q4 and full year 2025 on January 29, 2026, before market opens [1] Financial Performance - The company will hold a conference call on the same day at 8:30 a.m. ET to discuss its financial performance and future expectations [1] Communication - The conference call will be webcast live on the "Investors" section of the company's website [1]

Group 1: Market Overview - The S&P 500 Index experienced a significant surge in Q3 2025, driven by investor optimism due to expectations of monetary easing, strong consumer demand, and solid corporate earnings [1] - The Parnassus Core Equity Fund (Investor Shares) returned 2.57% in Q3 2025, underperforming the S&P 500 Index, which returned 8.12% [1] - Year-to-date, the fund's return was 9.89%, compared to 14.83% for the S&P 500 Index [1] Group 2: Company Focus - Thermo Fisher Scientific Inc. - Thermo Fisher Scientific Inc. (NYSE:TMO) is highlighted as a key stock in the Parnassus Core Equity Fund's Q3 2025 investor letter, offering a range of life sciences solutions and services [2][3] - The stock of Thermo Fisher Scientific Inc. had a one-month return of -3.69% but gained 8.83% over the last 52 weeks, closing at $575.70 per share with a market capitalization of $216.3 billion on December 22, 2025 [2] - The company recovered from being oversold earlier in the year, supported by favorable financial results and guidance that exceeded expectations [3] Group 3: Investment Sentiment - Thermo Fisher Scientific Inc. ranked 26th on the list of the 30 Most Popular Stocks Among Hedge Funds, with 121 hedge fund portfolios holding the stock at the end of Q3 2025, an increase from 117 in the previous quarter [3] - While acknowledging the potential of Thermo Fisher Scientific Inc. as an investment, the company believes that certain AI stocks may offer greater upside potential and carry less downside risk [3]

Core Insights - Thermo Fisher Scientific Inc. (TMO) has initiated the enrollment of the first patient in its PPD CorEvitas Alzheimer's Disease Registry, aimed at generating real-world data for evaluating drug safety and effectiveness [1][9] - Following the announcement, TMO shares experienced a slight decline of 0.03% [2] - The CorEvitas Alzheimer's Disease Registry enhances Thermo Fisher's portfolio of clinical registries, which includes data from over 100,000 patients across more than 500 investigator sites [3] Company Overview - Thermo Fisher has a market capitalization of $213.34 billion and an earnings yield of 3.9%, significantly higher than the industry's -3.5% yield [4] - The company has consistently surpassed earnings estimates in the past four quarters, achieving an average earnings surprise of 2.9% [4] Registry Details - The registry is designed to provide a comprehensive understanding of Alzheimer's therapy outcomes, focusing on long-term safety, treatment patterns, and the disease's impact on patients [5] - It includes detailed monitoring of drug safety events, such as MRI evaluations for brain bleeding and swelling, and measures of plaque clearance [6] Industry Context - Alzheimer's disease affects an estimated 7.2 million Americans aged 65 and older, representing a significant public health challenge [7][10] - The need for rigorous evidence to guide therapeutic development and patient care is underscored by the disease's status as a leading cause of death in the United States [10] Stock Performance - Over the past year, TMO shares have increased by 8.1%, outperforming the industry growth of 1.2% [12]

Core Viewpoint - Thermo Fisher Scientific Inc. (TMO) is recognized as one of the best stocks to buy in the S&P 500, with a consensus Strong Buy rating from analysts and a one-year price target indicating a potential upside of 12% [1]. Analyst Updates - Wells Fargo raised its price target for TMO to $675 from $635, citing improved clarity on U.S. pharmaceutical policies and positive growth projections [2]. - Citigroup upgraded TMO's rating to Buy from Neutral and increased its price target to $660 from $580, driven by favorable trends in onshoring and pharmaceutical spending [3]. Company Overview - Thermo Fisher Scientific is a leading provider of life sciences solutions, laboratory products, diagnostics, analytical instruments, and biopharma services, with an 8% gain year-to-date in 2025 [4].