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IDEAYA Biosciences and Hengrui Pharma Present Positive Phase 1 Data for IDE849 (SHR-4849), a Potential First-in-Class DLL3 TOP1 ADC, in Small Cell Lung Cancer at the IASLC 2025 World Conference on Lung Cancer
Prnewswire· 2025-09-07 16:00
Core Insights - IDEAYA Biosciences and Hengrui Pharma presented initial data from Hengrui's Phase 1 clinical trial of IDE849, a DLL3-targeting TOP1 antibody drug conjugate, at the IASLC 2025 World Conference on Lung Cancer [1][2] Efficacy Data - The trial included 100 patients, with 87 having small-cell lung cancer (SCLC) and 13 with other neuroendocrine carcinomas (NEC) [2] - In the expansion phase, 71 evaluable SCLC patients showed an overall response rate (ORR) of 73.2% across all lines of therapy [3][4] - At the 2.4 mg/kg dose, the ORR was 80.0% in 2L SCLC and 73.7% across all lines of SCLC [4][10] - A median progression-free survival (PFS) of 6.7 months was observed across all lines of SCLC [10] Safety Profile - Among 100 patients treated, 48% experienced Grade 3 or higher treatment-related adverse events (TRAEs) [10] - The most common TRAEs included neutropenia (33% Gr>3) and white blood cell reduction (27% Gr>3) [10] - The treatment-related discontinuation rate was 2%, with no treatment-related deaths reported [10] Collaboration and Future Development - Hengrui Pharma granted IDEAYA an exclusive worldwide license to develop and commercialize IDE849 outside of Greater China [7] - IDEAYA aims to advance the global clinical development of IDE849 for SCLC, NETs, and other DLL3 upregulated solid tumors [2][7]
ROSEN, A TOP RANKED LAW FIRM, Encourages Lineage, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action – LINE
GlobeNewswire News Room· 2025-09-05 02:27
Group 1 - The Rosen Law Firm is reminding purchasers of Lineage, Inc. common stock about the September 30, 2025 lead plaintiff deadline related to the class action lawsuit following Lineage's July 2024 IPO [1][3] - Investors who purchased Lineage common stock may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2][5] - The lawsuit claims that the registration statement issued during the IPO was misleading, failing to disclose significant issues such as weakening customer demand and unsustainable price increases [5] Group 2 - The lawsuit alleges that Lineage was experiencing stagnant or falling revenue, occupancy rates, and rent prices, contrary to the representations made in the registration statement [5] - The Rosen Law Firm has a strong track record in securities class actions, having recovered hundreds of millions of dollars for investors, including over $438 million in 2019 alone [4] - Investors interested in joining the class action can find more information through the Rosen Law Firm's website or by contacting their representatives [3][6]
ROSEN, TOP RANKED GLOBAL COUNSEL, Encourages XPLR Infrastructure, LP f/k/a Nextera Energy Partners, LP Investors to Secure Counsel Before Important Deadline in Securities Class Action – XIFR, NEP
GlobeNewswire News Room· 2025-09-01 18:53
Core Viewpoint - Rosen Law Firm is reminding purchasers of XPLR Infrastructure, LP common units of a class action lawsuit with a lead plaintiff deadline of September 8, 2025, for those who bought units between September 27, 2023, and January 27, 2025 [1] Group 1: Class Action Details - Investors who purchased XPLR common units during the specified Class Period may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2] - A class action lawsuit has already been filed, and interested parties can join by contacting Rosen Law Firm [3][6] - Investors wishing to serve as lead plaintiff must file with the Court by September 8, 2025 [3] Group 2: Rosen Law Firm's Credentials - Rosen Law Firm emphasizes the importance of selecting qualified counsel with a successful track record in securities class actions [4] - The firm has achieved significant settlements, including the largest securities class action settlement against a Chinese company at the time, and has recovered hundreds of millions for investors [4] - In 2019, the firm secured over $438 million for investors, and its founding partner was recognized as a Titan of Plaintiffs' Bar by Law360 in 2020 [4] Group 3: Case Allegations - The lawsuit alleges that XPLR made false and misleading statements regarding its operations as a yieldco, including struggles to maintain operations and the unsustainability of its business model [5] - It is claimed that XPLR entered financing arrangements while downplaying risks, which ultimately led to a halt in cash distributions to investors [5] - The lawsuit asserts that the public statements made by the defendants were materially false and misleading, resulting in investor damages when the truth was revealed [5]
ROSEN, TOP RANKED INVESTOR COUNSEL, Encourages Encompass Health Corporation Investors to Inquire About Securities Class Action Investigation – EHC
GlobeNewswire News Room· 2025-09-01 18:52
Core Viewpoint - Rosen Law Firm is investigating potential securities claims on behalf of shareholders of Encompass Health Corporation due to allegations of materially misleading business information [1] Group 1: Investigation and Allegations - The investigation is prompted by an article from The New York Times highlighting serious incidents of patient harm and below-average performance on key safety measures at Encompass Health's rehab hospitals [3] - Following the publication of the article, Encompass Health's stock price dropped by 10.3% on July 15, 2025 [3] Group 2: Class Action Details - Investors who purchased Encompass Health securities may be entitled to compensation through a class action lawsuit without any out-of-pocket fees [2] - The Rosen Law Firm is preparing a class action to seek recovery of investor losses [2] Group 3: Rosen Law Firm's Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved the largest securities class action settlement against a Chinese company at the time [4] - The firm has been ranked in the top 4 for securities class action settlements since 2013 and recovered hundreds of millions of dollars for investors, including over $438 million in 2019 [4]
ROSEN, TOP RANKED GLOBAL COUNSEL, Encourages Luminar Technologies, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - LAZR
GlobeNewswire News Room· 2025-08-31 17:59
Core Viewpoint - Rosen Law Firm is reminding investors who purchased Luminar Technologies, Inc. securities during the specified Class Period of the upcoming lead plaintiff deadline for a class action lawsuit [1][3]. Group 1: Class Action Details - Investors who purchased Luminar securities between March 20, 2025, and May 14, 2025, may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. - A class action lawsuit has already been filed, and interested parties must move the Court to serve as lead plaintiff by September 22, 2025 [3]. Group 2: Law Firm Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved the largest securities class action settlement against a Chinese company at the time and being ranked No. 1 for the number of settlements in 2017 [4]. - The firm has recovered hundreds of millions of dollars for investors, securing over $438 million in 2019 alone [4]. Group 3: Case Allegations - The lawsuit alleges that Luminar's executives made false and misleading statements, including undisclosed conduct by CEO Austin Russell that could lead to his removal, adversely affecting the company's business and financial guidance [5]. - The negative public perception and news related to Russell could harm Luminar's brand relationships and competitive standing in the industry [5].
ROSEN, TOP RANKED INVESTOR COUNSEL, Encourages Luminar Technologies, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - LAZR
GlobeNewswire News Room· 2025-08-25 21:33
Core Viewpoint - Rosen Law Firm is reminding investors who purchased Luminar Technologies, Inc. securities during the specified Class Period of the upcoming lead plaintiff deadline on September 22, 2025 [1] Group 1: Class Action Details - Investors who purchased Luminar securities between March 20, 2025, and May 14, 2025, may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2] - A class action lawsuit has already been filed, and interested parties must move the Court to serve as lead plaintiff by September 22, 2025 [3] - Investors are encouraged to select qualified counsel with a successful track record in securities class actions [4] Group 2: Case Allegations - The lawsuit alleges that Luminar's executives made false and misleading statements and failed to disclose critical information regarding CEO Austin Russell's undisclosed conduct, which could lead to his removal [5] - The potential loss of Russell could adversely affect Luminar's business operations, including competition, R&D management, and customer relationships [5] - The lawsuit claims that Luminar had no reasonable basis for its financial guidance, and the public statements made by the defendants were materially false and misleading [5]
ROSEN, TOP RANKED INVESTOR COUNSEL, Encourages Lockheed Martin Corporation Investors to Secure Counsel Before Important Deadline in Securities Class Action – LMT
GlobeNewswire News Room· 2025-08-25 20:31
Core Viewpoint - Rosen Law Firm is reminding investors who purchased Lockheed Martin securities between January 23, 2024, and July 21, 2025, of the September 26, 2025, deadline to become lead plaintiffs in a class action lawsuit [1]. Group 1: Class Action Details - Investors who purchased Lockheed Martin securities during the specified Class Period may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. - A class action lawsuit has already been filed, and interested parties must move the Court to serve as lead plaintiff by September 26, 2025 [3]. - The lawsuit alleges that Lockheed Martin made false and misleading statements regarding its internal controls and ability to meet contract commitments, which led to significant investor losses when the truth was revealed [5]. Group 2: Rosen Law Firm's Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved the largest securities class action settlement against a Chinese company at the time and being ranked No. 1 for the number of settlements in 2017 [4]. - The firm has recovered hundreds of millions of dollars for investors, securing over $438 million in 2019 alone [4]. - Founding partner Laurence Rosen was recognized as a Titan of Plaintiffs' Bar by Law360 in 2020, and many attorneys at the firm have received accolades from Lawdragon and Super Lawyers [4].
TOP Financial Group Limited Announces New Corporate Headquarters in Singapore
Globenewswire· 2025-08-25 12:00
Company Overview - TOP Financial Group Limited is a fast-growing online brokerage firm based in Hong Kong, specializing in trading local and foreign equities, futures, options products, and other financial services [1][3] - The company has relocated its headquarters to Singapore, which is recognized as a major financial center with stable political policies, economic growth, and a low tax rate [2] Strategic Expansion - The relocation to Singapore is part of the company's strategic expansion plan to explore new business opportunities in Southeast Asia [2] - TOP Financial Pte Ltd., a subsidiary of the company, obtained a capital market services (CMS) license from the Monetary Authority of Singapore in June 2025, enhancing product diversification and investor flexibility [2][4] Services Offered - The company provides a range of diversified services through its operating subsidiaries, including online brokerage platforms, asset and funds management, trading solutions, money lending, trust services, and investor relations [3][4] - The operating subsidiaries are licensed with the Securities and Futures Commission of Hong Kong to conduct various regulated activities, including dealing in securities and futures contracts [4] Recent Acquisitions - TOP Financial Group has completed the acquisition of an Australia licensed company, TOP 500 Sec Pty Ltd, which will enable it to provide dealing services in derivatives and foreign exchange contracts [4] - The company has also acquired Zhong Yang Financial Services Limited, which will offer investor relations and public relations services, and is in the process of acquiring a TCSP license in Hong Kong [4]
ROSEN, A TOP RANKED LAW FIRM, Encourages PubMatic, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action – PUBM
GlobeNewswire News Room· 2025-08-25 00:02
Core Viewpoint - Rosen Law Firm has filed a class action lawsuit on behalf of investors who purchased PubMatic, Inc. securities between February 27, 2025, and August 11, 2025, due to alleged misleading statements by the company regarding its business operations and revenue impacts from a significant demand side platform buyer [1][5]. Group 1: Lawsuit Details - The class action lawsuit claims that PubMatic made false and misleading statements about its business, failing to disclose a shift of clients from a top demand side platform buyer to a new platform, which resulted in reduced ad spend and revenue [5]. - Investors who purchased PubMatic securities during the specified Class Period may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. Group 2: Next Steps for Investors - Investors interested in joining the class action can do so by visiting the provided link or contacting the law firm directly for more information [3][6]. - A lead plaintiff must be appointed by October 20, 2025, to represent the class in the litigation [1][3]. Group 3: Rosen Law Firm's Credentials - Rosen Law Firm has a strong track record in securities class actions, having achieved significant settlements, including the largest securities class action settlement against a Chinese company at the time [4]. - The firm has consistently ranked highly in securities class action settlements and has recovered hundreds of millions of dollars for investors [4].
ROSEN, A TOP RANKED LAW FIRM, Encourages Alto Neuroscience, Inc. Investors to Secure Counsel Before Important Deadline in Securities Class Action - ANRO
GlobeNewswire News Room· 2025-08-24 15:31
Core Viewpoint - Rosen Law Firm is reminding investors who purchased common stock of Alto Neuroscience, Inc. during the IPO and the subsequent class period about the upcoming lead plaintiff deadline for a class action lawsuit [1][5]. Group 1: Class Action Details - Investors who purchased Alto securities may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. - A class action lawsuit has already been filed, and interested parties must move the Court to serve as lead plaintiff by September 19, 2025 [3]. - The lawsuit alleges that defendants made materially false and misleading statements regarding Alto's business and prospects, particularly concerning the effectiveness of ALTO-100 in treating major depressive disorder [5]. Group 2: Rosen Law Firm's Credentials - Rosen Law Firm emphasizes the importance of selecting qualified counsel with a successful track record in securities class actions, highlighting its own achievements in this area [4]. - The firm has secured significant settlements for investors, including over $438 million in 2019 alone, and has been consistently ranked among the top firms for securities class action settlements [4].