Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 __________________________________________________________ FORM 10-Q __________________________________________________________ (Mark One) x QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from___________to Commission F ...

Vir Biotechnology (VIR) Q2 2025 Earnings Call August 06, 2025 04:30 PM ET Speaker0Hello. Welcome to Veer Biotechnologies Second Quarter twenty twenty five Financial Results and Corporate Update Call. As a reminder, this conference call is being recorded. At this time, all participants are in a listen only mode. After the speakers' remarks, there will be a question and answer session.I will now turn the call over to Rich Leppke, Senior Director, Investor Relations. You may begin, Mr. Leppke.Speaker1Thank you ...

Corporate Overview Presentation August 2025 2025 Vir Biotechnology, Inc. 1 Legal disclaimer Forward-Looking Statements Statements in this presentation that are not statements of historical fact are forward-looking statements. Such forward-looking statements include, without limitation, statements regarding: the therapeutic and commercial potential of Vir Biotechnology's CHD program, as well as Vir Biotechnology's strategy, plans and expectations related thereto; the therapeutic and commercial potential of V ...

Exhibit 99.1 Vir Biotechnology Provides Corporate Update and Reports Second Quarter 2025 Financial Results – ECLIPSE registrational program in chronic hepatitis delta fully underway – First patient dosed in Phase 1 study of VIR-5525, an EGFR-targeting PRO-XTEN™ dual-masked T-cell engager; advancing oncology clinical pipeline with three ongoing Phase 1 studies – Strong financial position and runway into mid-2027 with approximately $892.1 million in cash and investments as of June 30, 2025 – Conference call s ...

Company Overview - Vir Biotechnology, Inc. (VIR) is expected to report a year-over-year increase in earnings driven by higher revenues for the quarter ended June 2025, with a consensus outlook indicating a quarterly loss of $0.72 per share, reflecting a +29.4% change from the previous year [1][3] - Revenues are anticipated to reach $7.64 million, representing a significant increase of 148.1% compared to the same quarter last year [3] Earnings Estimates and Revisions - The consensus EPS estimate has been revised 7.54% higher in the last 30 days, indicating a collective reassessment by analysts [4] - The Most Accurate Estimate for Vir Biotechnology is lower than the Zacks Consensus Estimate, resulting in an Earnings ESP of -22.91%, suggesting a bearish outlook from analysts [12] Earnings Surprise Prediction - The Zacks Earnings ESP model indicates that a positive or negative reading can predict the deviation of actual earnings from consensus estimates, but the predictive power is significant primarily for positive readings [9][10] - Vir Biotechnology currently holds a Zacks Rank of 3, which complicates the prediction of an earnings beat given the negative Earnings ESP [12] Historical Performance - In the last reported quarter, Vir Biotechnology was expected to post a loss of $0.83 per share but actually reported a loss of -$0.88, resulting in a surprise of -6.02% [13] - Over the past four quarters, the company has only beaten consensus EPS estimates once [14] Industry Context - In the Zacks Medical - Biomedical and Genetics industry, Beam Therapeutics Inc. (BEAM) is also expected to report a loss of $1.04 per share for the same quarter, with revenues projected at $13.79 million, up 17.2% year-over-year [18][19] - Beam Therapeutics has an Earnings ESP of -23.08% and a Zacks Rank of 4, indicating challenges in predicting an earnings beat [20]

Vir Biotechnology (NASDAQ: VIR ) is a stock I covered back in January after a meteoric rally in share price, and I came away with optimism despite the fact that there was serious risk associated withI have my PhD in biochemistry and have worked for years analyzing clinical trials and biotech companies. It is my passion to educate everyone possible on the science behind the businesses that we invest in, and it's my mission to help you do your due diligence and not get burned by the pitfalls of investing in t ...

Company Overview - Vir Biotechnology, Inc. (VIR) shares increased by 11.9% to close at $5.93, with trading volume significantly higher than usual, contrasting with a 2.2% loss over the past four weeks [1][2] Pipeline and Development - The rise in stock price is linked to positive investor sentiment regarding tobevibart, Vir Biotechnology's late-stage pipeline candidate, which is in a phase III ECLIPSE 1 study for chronic hepatitis delta (CHD) treatment [2] - The company is preparing to start a phase III ECLIPSE 2 study to evaluate the efficacy and safety of switching to tobevibart and elebsiran for CHD patients not achieving viral suppression with bulevirtide [2] Financial Expectations - The upcoming quarterly report is expected to show a loss of $0.74 per share, reflecting a year-over-year increase of 27.5%, while revenues are projected at $7.05 million, up 128.8% from the previous year [3] - The consensus EPS estimate for the quarter has remained unchanged over the last 30 days, indicating that stock price movements may not sustain without trends in earnings estimate revisions [4] Industry Context - Vir Biotechnology operates within the Zacks Medical - Biomedical and Genetics industry, which includes other companies like Opus Genetics, Inc. (IRD), that also has a Zacks Rank of 2 (Buy) [4][5]

Summary of Vir Biotechnology (VIR) FY Conference Call Company Overview - **Company**: Vir Biotechnology (VIR) - **Date of Conference**: May 27, 2025 - **Key Speakers**: Marianne DeBacker (CEO), Mika Derink (Executive VP of Therapeutic Oncology) Core Areas of Focus - **Hepatitis Delta Infections**: - Significant unmet need as patients with hepatitis B can rapidly progress to liver cirrhosis or hepatocellular carcinoma - ECLIPSE program is in registrational trials with no approved treatments in the US for hepatitis delta infection [3][4] - **Metastatic Solid Tumors**: - Development of a masked T cell engager platform showing promising data - Proof of concept established in two clinical studies targeting HER2 and PSMA, with a third program targeting EGFR set to start [4][5] Pipeline and Financial Position - **Pipeline Strength**: - Differentiated PRO X10 dual masking technology enhances safety and therapeutic index - Seven preclinical programs initiated alongside ongoing clinical studies [5][6] - **Financial Position**: - Approximately $1 billion in cash, providing runway into mid-2027 to advance key programs [6] Strategic Partnerships - **Acquisition of Pro X10 Platform**: - Acquired worldwide rights from Sanofi for oncology and infectious disease applications - Deal included upfront payment of $100 million and additional milestone payments [9][10] Clinical Trials and Data - **PSMA Targeted T Cell Engager (VIR 5500)**: - Early dose escalation data showed a 58% PSA50 response rate and an 8% PSA90 response rate in heavily pretreated patients [17][18] - No prophylactic steroids required, indicating a favorable safety profile [18][22] - **HER2 Program (VER 5818)**: - Combination with pembrolizumab showed a 50% tumor shrinkage rate in HER2 positive patients, with a 33% confirmed response rate in colorectal cancer subset [38][39] - Ongoing evaluation of dosing schedules and safety [39][45] - **EGFR Program (VIR 5525)**: - Anticipated first-in-human dosing in the first half of the year, with promising preclinical data [46] Hepatitis Delta Program - **ECLIPSE Trials**: - First patient dosed in ECLIPSE one trial, targeting completion of enrollment by the end of the year - Primary completion date for ECLIPSE one is December 2026, with potential data from ECLIPSE two available around the same timeframe [47][48][49] Regulatory Designations - The hepatitis delta program has received breakthrough designation, fast track designation, prime designation, and orphan drug designation, indicating a high unmet need and expedited development process [49] Conclusion - Vir Biotechnology is strategically focused on addressing significant unmet medical needs in hepatitis delta infections and metastatic solid tumors through innovative therapies and a strong financial position, with ongoing clinical trials expected to yield important data in the near future [50][51]

Summary of Vir Biotechnology (VIR) Conference Call Company Overview - **Company**: Vir Biotechnology (VIR) - **Event**: 2025 Bank of America Healthcare Conference - **Date**: May 14, 2025 Key Focus Areas - **Clinical Stage Pipeline**: The company is focused on two main areas: fighting infections and cancer using the human immune system [4][5] - **Hepatitis Delta Virus (HDV)**: The most advanced program targeting an orphan liver disease with no current treatments in the U.S. [5][19] - **Masked T Cell Engagers**: Programs targeting metastatic solid tumors, including HER2 and PSMA, both in phase one dose escalation [6][7] Hepatitis Delta Virus (HDV) Program - **ECLIPSE Trials**: - ECLIPSE one: For treatment-naive patients, primary completion expected by December 2026 [17][25] - ECLIPSE two: For patients on existing treatment (belabertide), with a 24-week endpoint [15][25] - ECLIPSE three: Head-to-head trial against belabertide [16] - **Compelling Data**: In the Solstice trial, 64% of patients achieved undetectable virus levels after 36 weeks [13] - **Market Need**: High mortality rate (50%) among untreated patients in the U.S. [19][20] - **Awareness Initiatives**: Working with KOLs and advocacy groups to increase awareness and improve diagnosis rates [29][30] T Cell Engager Platform - **ProXtent Platform**: A unique plug-and-play platform with a hydrophilic mask that enhances safety and efficacy [39][41] - **Dosing Flexibility**: Programs exploring every three-week dosing schedules, which could improve patient convenience [44][47] - **HER2 Program**: - Basket trial design with significant responses in various tumor types, including colorectal cancer [49][51] - 33% confirmed partial response in colorectal cancer patients at higher doses [51] - **PSMA Program**: - Early data shows robust PSA responses, with 58% achieving PSA 50 response [53] - Focus on therapeutic index to balance efficacy and safety [55] EGFR Program - **Upcoming Trials**: Targeting EGFR-positive patients in head and neck, lung, and colorectal cancers, with monotherapy and combination studies planned [56][58] Financial Overview - **Cash Position**: Approximately $1 billion, providing a runway into mid-2027 [63] - **Capital Allocation**: Prioritizing clinical stage programs while exploring partnerships for preclinical targets [66] Future Data Updates - **Expected Data Releases**: Anticipated updates on ECLIPSE trials, HER2, PSMA, and EGFR programs between now and 2027 [64] Conclusion - Vir Biotechnology is positioned to address significant unmet medical needs in both infectious diseases and oncology, with a strong pipeline and strategic focus on enhancing patient outcomes through innovative therapies and partnerships.

Company Performance - Vir Biotechnology reported a quarterly loss of $0.88 per share, which was worse than the Zacks Consensus Estimate of a loss of $0.83, and compared to a loss of $0.48 per share a year ago, indicating a significant decline in performance [1] - The company posted revenues of $3.03 million for the quarter ended March 2025, missing the Zacks Consensus Estimate by 84.51%, and a sharp decline from year-ago revenues of $56.38 million [2] - Over the last four quarters, Vir Biotechnology has only surpassed consensus EPS estimates once, indicating ongoing challenges in meeting market expectations [2] Stock Performance - Since the beginning of the year, Vir Biotechnology shares have lost approximately 23.3%, significantly underperforming the S&P 500, which declined by 4.7% [3] - The current consensus EPS estimate for the upcoming quarter is -$0.84 on revenues of $15.97 million, and for the current fiscal year, it is -$3.40 on revenues of $61.56 million [7] Industry Outlook - The Medical - Biomedical and Genetics industry, to which Vir Biotechnology belongs, is currently ranked in the top 35% of over 250 Zacks industries, suggesting a relatively strong position within the sector [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which could impact Vir Biotechnology's stock performance [5]