Alkermes (NasdaqGS:ALKS) Q4 2025 Earnings call February 25, 2026 08:00 AM ET Speaker12Greetings, and welcome to the Alkermes' fourth quarter 2025 financial results conference call. My name is Melissa, and I will be your operator for today's call. All participant lines will be placed on mute to prevent background noise. If you should require operator assistance during the call, please press star 0 on your telephone keypad. Please note that this conference is being recorded. I will now turn the call over to S ...

Group 1 - Alkermes plc (NASDAQ:ALKS) is considered a promising mid-cap healthcare stock under $50, with a consensus of 11 Buy ratings and 4 Holds from 15 analysts, indicating a median 1-year price target of $46.17, representing a 62.3% upside potential [1] - The company plans to acquire Avadel, which has a topline of approximately $275 million, as part of its strategy to enter the hypersomnolence market and launch alixorexton, an oral drug for complex sleep disorders [2] - Analyst David Amsellem from Piper Sandler reaffirmed a Buy rating for Alkermes with a price target of $45, suggesting more than 58% upside potential for investors [3] Group 2 - Alkermes is a biopharmaceutical company focused on developing and commercializing innovative medicines for neurological disorders, utilizing proprietary technologies for formulations aimed at psychiatric conditions [4]

Core Insights - The company experienced a transformational year, marking one of the most consequential periods in its history [1] - The acquisition of Avadel and the development of NT1 and NT2 data have positioned the company to enter the hypersomnolence market [1] - The commercial portfolio has performed well, with positive results from NT1 and NT2 data, and ongoing enrollment in the IH study [1] Company Developments - The company has made significant strides in the orexin receptor agonist class, indicating a strong market position [1] - The year has been characterized by key milestones that have enhanced the company's commercial capabilities [1] - The company is optimistic about its future prospects in a new commercial domain after years of preparation [1]

Alkermes FY Conference Summary Company Overview - **Company**: Alkermes (NasdaqGS: ALKS) - **Date of Conference**: December 03, 2025 Key Industry Insights - **Hypersomnia Market**: Alkermes is moving aggressively into the hypersomnia market, which is a new commercial domain for the company after years of focus on other areas [2][3] - **Orexin Receptor Agonist Class**: The landscape of the orexin receptor agonist class is becoming clearer, positioning Alkermes favorably within this setting [3] Financial and Strategic Highlights - **Acquisition of Avadel**: Alkermes intends to acquire Avadel, which has $275 million in sales this year and is already profitable. This acquisition is seen as a strategic move to enhance their position in the hypersomnia market [5][15] - **Valuation Methodology**: The valuation of Avadel was assessed through discounted cash flows and the anticipated positive impact on the launch of ALKS 2680 [5][6] - **Gross-to-Net Dynamics**: Alkermes has a strong understanding of gross-to-net dynamics, which is crucial for assessing the commercial value of their products [8][9] Product Development and Pipeline - **ALKS 2680**: This product is expected to be a significant launch for Alkermes, targeting narcolepsy, a rare disease. The anticipated high price point and medical value are highlighted [12][13] - **Cognition Data**: Alkermes claims to be the only company to show significant effects on cognition and fatigue in a randomized controlled study for orexin, which is critical for patient care in narcolepsy [21][22] - **Future Indications**: The company is exploring multiple indications for orexin beyond narcolepsy, with ongoing clinical trials and a focus on patient populations and pricing strategies [27][28] Research and Development (R&D) Strategy - **R&D Funding**: Alkermes aims to fund its orexin program aggressively while maintaining profitability. The company does not foresee financial constraints in pursuing its R&D goals [34][35] - **Clinical Trials**: The company is preparing for phase three trials for narcolepsy, with a robust data set from phase two studies. The timing for these trials is set for Q1 [41][42] Market Position and Competitive Advantage - **Commercial Infrastructure**: The acquisition of Avadel allows Alkermes to leverage existing commercial infrastructure, enhancing market access and compliance without the need to build a new team from scratch [13][15] - **Dosing Flexibility**: Alkermes plans to offer a range of doses for its products, which could provide a competitive advantage in the market by accommodating different patient needs [44] Conclusion - Alkermes is positioned for significant growth in the hypersomnia market through strategic acquisitions and a strong product pipeline. The company emphasizes its understanding of market dynamics and its commitment to maintaining profitability while expanding its R&D efforts.

Core Insights - Merck has agreed to acquire Cidara Therapeutics for $9.2 billion, significantly boosting Cidara's stock value by approximately 110% to $221.50 per share [1][2] - Cidara's CD388 flu prevention program is viewed as a promising opportunity, with an estimated market potential of $3.8 billion, especially following the announcement of a registrational phase III program [2] Company Developments - Cidara Therapeutics' stock surged nearly 105% to $217.05 in morning trades following the acquisition announcement [2] - Merck's stock experienced a slight decline, falling to $92.83 [2] Market Context - The acquisition reflects a strategic move by Merck to enhance its portfolio in the biotech sector, particularly in antiviral treatments [1][2]

The unsolicited bid—worth up to $2.25 billion —potentially upends Avadel's deal to be acquired by Alkermes. ...

Summary of Alkermes Conference Call Company Overview - **Company**: Alkermes (NasdaqGS:ALKS) - **Event**: 2025 Conference on November 13, 2025 Key Industry Insights - **Focus Area**: Development of drugs for narcolepsy, specifically targeting narcolepsy type 1 (NT1) and type 2 (NT2) with the Rexin compound [2][8] - **Market Dynamics**: The company is addressing major unmet medical needs in the narcolepsy patient population, which has been historically under-researched [8][9] Core Findings from Recent Data Release - **Study Design**: The recent data release focused on NT2 patients, providing new insights into a previously under-studied population [9] - **Efficacy Signal**: The drug demonstrated a clear efficacy signal, particularly in the Maintenance of Wakefulness Test (MWT) at hour two and hour four, despite variability in patient responses [12][14] - **Tolerability**: Higher doses were well tolerated by NT2 patients, contradicting previous assumptions that higher doses would lead to increased adverse effects [10][17] - **Adverse Events**: Commonly reported adverse events included polyuria, urinary urgency, insomnia, and visual disturbances, but these did not significantly impact overall tolerability [17] Statistical Analysis and Drug Development - **Statistical Significance**: The study employed a phase three statistical plan in a phase two study, which complicated the interpretation of some lower doses [54][56] - **Dose Response**: There was a clear dose response observed in individual patient levels, although averaging across responders and non-responders obscured this [15][17] - **Future Studies**: Plans for phase three studies are underway, with a focus on both NT1 and NT2 populations, utilizing MWT and Epworth Sleepiness Scale (ESS) as primary endpoints [87][88] Competitive Landscape - **Market Position**: Alkermes is positioned as a pioneer in the NT2 space, with no direct competitors currently offering similar treatments [43][44] - **Comparison with Existing Treatments**: Current treatments like Provigil and Xyrem have not focused on pure NT2 cohorts, making Alkermes' data unique [46][50] Commercial Strategy and Financial Health - **Revenue Growth**: The company reported continuous growth driven by demand, with a billion-plus dollar top line generating significant profitability [94] - **Acquisition Strategy**: The acquisition of Avadel is being funded through cash generated from strong business performance, avoiding stock dilution [94] Regulatory Environment - **FDA Engagement**: Alkermes is preparing for a type B meeting with the FDA to discuss phase three study designs and endpoints, with expectations to initiate the program in early Q1 [87][88] - **PDUFA 8 Reauthorization**: The company is optimistic about the reauthorization of user fees that fund drug reviews, which is crucial for the drug development process [97][98] Future Directions - **Research Expansion**: Alkermes is exploring additional indications beyond narcolepsy and hypersomnolence, with plans to advance new rexins into clinical trials by 2026 [90] - **Focus on Cognition and Fatigue**: The company aims to incorporate measures of cognition and fatigue into future studies, addressing patient-reported outcomes that are critical for treatment satisfaction [88][89] This summary encapsulates the key points discussed during the conference call, highlighting Alkermes' strategic focus, recent findings, and future plans in the context of the narcolepsy treatment landscape.

Core Insights - The article highlights the author's background as a recent graduate with a strong focus on equity and commodity markets, valuation modeling, and financial derivatives [1] - The author expresses a keen interest in modeling businesses within sectors such as AI, semiconductors, biotech, natural resources, and mining [1] Company and Industry Focus - The author is actively seeking and modeling new opportunities in capital markets, indicating a proactive approach to investment analysis [1] - The sectors of interest, including AI and semiconductors, are positioned as high-potential areas for investment, reflecting current market trends and technological advancements [1]