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Rhythm Pharmaceuticals Presents Data on MC4R Agonists Setmelanotide and Bivamelagon at ENDO 2025
GlobeNewswire News Room· 2025-07-12 22:00
Core Insights - Rhythm Pharmaceuticals presented new data on acquired hypothalamic obesity at the Endocrine Society's Annual Meeting (ENDO 2025), highlighting the efficacy of setmelanotide and bivamelagon in reducing body mass index (BMI) in affected patients [1][2][3] Group 1: Clinical Data and Efficacy - The Phase 3 TRANSCEND trial demonstrated significant BMI reductions with setmelanotide, showing a -9.3% reduction in the 600mg cohort, -7.7% in the 400mg cohort, and -2.7% in the 200mg cohort, while the placebo cohort experienced a 2.2% increase [4][5] - A placebo-adjusted difference of -19.8% in BMI reduction was observed across 120 participants, with significant reductions noted in various age and sex subgroups [5][6] - Bivamelagon, a daily oral MC4R agonist, also showed statistically significant BMI reductions in a Phase 2 trial, indicating its potential as a transformative treatment option for patients with acquired hypothalamic obesity [2][3] Group 2: Patient Population and Market Potential - Acquired hypothalamic obesity is a rare condition affecting an estimated 5,000 to 10,000 individuals in the U.S., with similar prevalence in Japan and the E.U. [11][10] - The condition is characterized by rapid weight gain and hyperphagia due to damage to the hypothalamic region of the brain, often following brain tumors or their treatment [10][11] - The presentations at ENDO 2025 underscore the potential for MC4R-targeted therapies to become the standard of care for this patient community if approved [2][3]
This Daily Product Is More Dangerous Than You Think 🤯
The Diary Of A CEO· 2025-07-12 21:30
This is one of the worst products that you can use. I've been using it every day. Yeah.So, I'll tell you why. Aerosols use propellants. Propellants are derived from petroleum.And there was a recall on thousands of products within the last couple years that the propellants were a source of benzene contamination. And benzene is a known human carcinogen that you do not want to be inhaling because what you inhale goes to your brain. It goes quickly all over your body through the bloodstream.You don't want to be ...
X @Easy
Easy· 2025-07-12 14:26
Forever grateful for the audience I’ve been able to build.Y’all are the real legends.This morning was a clear sign of that430 concurrent at peak felt literally unreal. A dream come true of sorts.Streaming on Kick was the right decision.Will go live for more of these major events for sure.I love you all. Thanks for rocking with meEasy (@EasyEatsBodega):12min Sell out for $PUMPalmost 400 live viewers on KickWHAT A MORNING ON THIS FINE WEEKEND.FILL THE WICK ON $PUMP I KNOW YA WANT TO!https://t.co/NDT5TzTGmB <- ...
NorthStar Gaming Announces Grant of Equity Incentive Awards to Non-Executive Directors in Lieu of Cash Compensation
Newsfile· 2025-07-12 12:31
Core Viewpoint - NorthStar Gaming Holdings Inc. has approved the grant of equity incentive awards to non-executive directors as a substitute for cash compensation, reflecting the company's strategy to reduce costs [1][2]. Group 1: Equity Incentive Awards - The company granted a total of 5,078,913 deferred share units (DSUs) to non-executive directors for their services in 2024 [2]. - The DSUs will vest immediately and can only be redeemed when a director ceases to hold their position [2]. - This move is part of the company's ongoing efforts to manage expenses effectively [2]. Group 2: Company Overview - NorthStar operates NorthStar Bets, a Canadian casino and sportsbook platform designed for high-stakes players, offering a premium gaming experience [3]. - The platform features a curated selection of popular games and an exclusive Sports Insights feature that integrates betting guidance, statistics, and scores [3]. - NorthStar aims to set a new standard in the industry by providing high-quality products and exceptional personalized service [4].
3 Growth Stocks Down 52% to 82% to Buy Right Now
The Motley Fool· 2025-07-12 12:00
Investing in growing companies can lead to great compound gains over the long term. But sometimes even competitively strong companies will see their stocks collapse over near-term headwinds in the economy or other obstacles. It's just the nature of business.Fortunately for long-term investors, traders on Wall Street don't look at it that way. The focus on near-term performance leads to swings in share prices that can over- or undervalue a company's true worth. This gives a retirement saver the chance to buy ...
X @CoinDesk
CoinDesk· 2025-07-11 20:44
RT CoinDesk Data (@CoinDeskData)📅 Month to date basket returns 👇🤖AI -12.40🟨CD20 12.75🔗DeFi 12.57💱Exchange Token 4.21%🌐Infrastructure 10.80%🧱Layer 1 12.45%🧱Layer 2 14.37%😂Meme 30.06🎮Metaverse/Gaming 14.93%🌎RWA 7.43%🌱Staking 15.83% https://t.co/GoyltbTFwd ...
Apple is poised to win the rights to stream F1 racing in the US
Business Insider· 2025-07-11 20:00
Apple had a box-office hit with "F1," the car-racing movie. Now it looks like it's going to double up on the sport, with a likely deal to stream Formula 1 races. The tech company appears to be the leading bidder for the US rights to show F1 races. The rights are currently held by Disney's ESPN.Apple has submitted a bid worth at least $150 million a year to stream the races starting in 2026. And ESPN isn't going to try to match or beat that, according to a source familiar with negotiations. So barring a la ...
X @Easy
Easy· 2025-07-11 19:09
Rather excited for this for many reasons.Etherlink is an ecosystem I have not yet been able to dive into, but seeing a reputable game dev studio opt to go this route has me VERY curious.REAPER ACTUAL, generated A TON of buzz on the timeline, and I am glad to be working with them.&& now with their official announcement to launch on the Tezos blockchain, I am very excited for what else is in store.The founder, John Smedley has made some CLEAR comments in regard to 'why is crypto required to do this', that sho ...
X @The Economist
The Economist· 2025-07-11 16:30
Critics decry dehumanising “video-game wars”. They are dismayed that gamification rewards killing. But the use of quantitative targets in war is not new https://t.co/4rFN8bYAXI ...
Warum Beziehungen keinen festen Fahrplan brauchen | Elisabeth Rieder | TEDxDonauinselSalon
TEDx Talks· 2025-07-11 16:14
[Musik] Stell dir vor, du steigst in eine Rolltreppe ein. Du kennst sie, diese Beziehungsrolltreppe. Du lernst jemanden kennen, verbringst Zeit mit dieser Person, verliebst dich, beschließt eine exklusive monogame Beziehung.Du ziehst zusammen, du heiratest, du bekommst Kinderhund und Kombiwagen. So läuft das oder. Beziehungen betreffen uns alle, denn wir sind soziale Wesen und können ohne Beziehungen nicht überleben.Beziehung ist aber kein Automatismus. Was, wenn du in Wahrheit ganz wo anders hin willst. Wa ...