Company Overview - Prickly Pear Health 专注于女性脑部健康医疗支持 [1] - 公司提供基于 AI 驱动的语音助手，帮助 30-50 岁女性应对影响脑部健康的荷尔蒙变化 [1]

Core Insights - Evofem Biosciences emphasizes the importance of access to contraception for health, future, and freedom on World Contraception Day [1] - The company aims to challenge the status quo in women's health by providing innovative, hormone-free contraceptive options [2][3] - Evofem's commitment includes education and awareness campaigns to reduce stigma around women's health issues [3][4] Product Offerings - PHEXXI is highlighted as the first and only hormone-free, on-demand contraceptive vaginal gel, applied before sexual activity [6] - SOLOSEC is an FDA-approved single-dose oral treatment for bacterial vaginosis and trichomoniasis, targeting women and individuals aged 12 and older [7] Company Vision and Initiatives - Evofem is dedicated to breaking barriers and expanding global access to women's health products [4] - The "Say Vagina" initiative has reached millions, aiming to improve health education and confront stigma [3][10]

Core Insights - Daré Bioscience has entered into an agreement with the Gates Foundation to receive up to approximately $499,000 for mentorship and project management support for research projects addressing preeclampsia, a significant unmet need in maternal care [1][2][3] Company Overview - Daré Bioscience is a biopharmaceutical company focused on women's health, aiming to bridge the gap between scientific innovation and practical solutions [1][5] - The company seeks to bring innovative, evidence-based solutions to market that address long-standing unmet needs in women's health, including areas such as contraception, sexual health, and menopause [5] Engagement Details - The engagement with the Gates Foundation will involve providing strategic mentorship and technical guidance to organizations conducting preclinical research on preeclampsia prevention, diagnosis, and treatment [2][3] - Preeclampsia is a leading cause of maternal and infant morbidity and mortality, with approximately 76,000 mothers and 500,000 babies dying from the condition each year [3][4] Strategic Alignment - This initiative aligns with Daré's long-term strategy to lead in women's health areas that have significant needs and limited treatment options [4][5] - The multi-year engagement aims to enhance the impact and sustainability of research funded through the Gates Foundation's Grand Challenges initiative [3][4]

Healthcare Access - One in three (33.33%) women in America have sought care at a Planned Parenthood clinic [1] - One in ten (10%) men in America have sought care at a Planned Parenthood clinic [1] Political Landscape - Conservatives have long desired to defund Planned Parenthood [1] - Defunding Planned Parenthood is becoming a reality [1]

Wealth & Finance - Larry Ellison's net worth increased by over $110 billion [1] Philanthropy & Investment - Melinda French Gates supports a $100 million partnership focused on women's health [1] News & Events - Charlie Kirk passed away at age 31 due to a shooting incident on Wednesday [1]

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on August 21, 2025 Registration No. 333-289722 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Femasys Inc. (Exact name of registrant as specified in its charter) Delaware 3841 11-3713499 (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identificat ...

Alzheimer's Research Advocacy - The Women's Alzheimer's Movement advocates for women's brain research [1] - The movement aims to rectify the narrative around Alzheimer's, which previously lacked focus on women [1] Media Mention - Maria Shriver, founder of The Women's Alzheimer's Movement, was featured in ForbesOver50 [1]

Brand & Advocacy - Halle Berry, actress and founder of Respin, advocates for women's menopausal health [1] - Halle Berry believes fighting for women's health is a legacy worth leaving [1] Media Mention - Forbes featured Halle Berry and her advocacy for women's health in ForbesOver50 [1]

TABLE OF CONTENTS Registration No. 333- As filed with the Securities and Exchange Commission on August 19, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Femasys Inc. (Exact name of registrant as specified in its charter) | elaware | | --- | (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 3841 11-3713499 (I.R.S. Employer Identificatio ...

Economic Impact of Neglecting Women's Health - The global economy loses over $1 trillion annually due to lost productivity, absenteeism, and healthcare costs related to women's health [7] - US employers lose over $225 billion annually in healthcare costs, significantly driven by delayed diagnoses and lower quality of care for women [7] - Pharmaceutical companies miss out on billions by having only 4% of their pipelines focused on female-only conditions [8] - Consumer health and technology companies lose hundreds of millions by developing solutions based on male-centric data [9] Systemic Issues in Women's Healthcare - Women's health is often an afterthought, a blind spot ingrained in how healthcare views women [5] - Over 80% of autoimmune disease patients are women, yet nearly all research (92%) is conducted on men [3] - Delays in diagnosing and treating women's health issues lead to significant economic and personal costs [2][3][7] - Traditional tests often overlook biomarkers and hormone fluctuations relevant to women's health [11] Opportunities in Women's Health (Femtech) - Reframing the conversation around women's health presents a significant economic and healthcare opportunity, potentially beyond a $500 billion market [6][10] - Femtech companies are creating innovative solutions designed around the entire life cycle and experiences of women [15] - AI and precision medicine can be used to improve drug development and predict sex-specific drug responses [12] Actions for Improvement - Challenge outdated narratives, question dismissive care, and refuse to downplay symptoms [18] - Policymakers, healthcare leaders, and technologists should ensure comprehensive policies and evaluate product development pipelines [19] - Physicians should advocate for more comprehensive medical training and question outdated diagnostic criteria [19]