So, my favorite holiday movie, The Santa Claus, you know, the one with Tim Allen. I get so excited for the day after Thanksgiving, where we put up the tree and we dive into Christmas. And the first thing I want to do, watch the Santa Claus.There's a scene in there where Tim Allen's character wakes up and he goes into the bathroom and he looks in the mirror and he's got this face full of fresh whiskers, this big round belly. Yeah, that was me when I started pmenopause. Uh, I remember standing in the kitchen ...

How Halle Berry Became The New Face Of Menopause https://t.co/r2xFL1Y65h ...

"There is a conversation happening now, but it's still very nascent."Cara Kamenev, president and CEO at Stripes Beauty, spoke about shattering the stigma around menopause at the #ForbesHealth Summit. https://t.co/Kya2dmUf6U https://t.co/3rz2Ncbf8b ...

Industry Trend - Halle Berry becomes the new face of menopause, indicating a shift in how the media and public perceive and represent menopause [1]

Drug Efficacy - GLP-1减肥药物在更年期后的效果不佳[1] Potential Solutions - 可能存在有效的药物组合方案[1]

Menopause and Estrogen's Impact - The decline of estrogen during perimenopause and menopause disrupts immune homeostasis, affecting the brain and emotions [3][7] - Estrogen receptors are located throughout the body, and their decline increases inflammatory cytokines, disrupting immune homeostasis and impacting neurotransmitter balance [7][8] - Decreased estrogen impacts BDNF (brain-derived neurotropic factor), affecting the brain's ability to grow, adapt, and recover, and also influences the hippocampus, impacting emotion and memory [8][9] - Biological disruptions during menopause can manifest as anxiety, depression, and cognitive brain fog [10] Resilience and Adaptation - Resilience is defined as the capacity to adapt and remain functional during biological shifts, and is crucial during menopause [13] - Estrogen modulates brain networks responsible for stress response, cognition, and emotional regulation [15] - Resilience is dynamic and depends on neuromimmune regulation and psychological adaptation [17] - Psychological adaptation is not adequately addressed in menopause treatment, despite the effectiveness of hormone therapy [18] Emotional Intelligence and Research - Cultivating emotional intelligence and capacity can help women adapt and thrive during menopause [20] - Emotional capacity and resilience include emotional stability, regulation, optimism, self-compassion, and self-trust [20] - The scientific community should quantify resilience, utilizing validated psychological questionnaires to assess women's well-being during perimenopause [22] - Combining neuroimmunology with the psychology of adaptation and resilience can redefine menopause, framing it as a dynamic period of growth [24]

Testosterone may be useful during menopause. A few studies suggest improvements in mood and cognition in post-menopausal women treated with the hormone https://t.co/h4TLVNsPKB ...

Hormone Replacement Therapy (HRT) Safety and Efficacy - The FDA Commissioner suggests removing black box warnings from HRT products, arguing they have unnecessarily deterred women from using these treatments [1][12] - A 2002 study led to a nearly 50% reduction in HRT use due to concerns about increased risks of heart disease and breast cancer [2] - Subsequent clinical trials have not confirmed that HRT increases breast cancer mortality, and cardiovascular complications are linked to starting HRT more than 10 years after menopause onset [4] - Starting HRT within 10 years of menopause onset can reduce heart disease risk by 30-50% and heart attack deaths by 48% [5] Benefits of HRT - HRT can alleviate menopause symptoms, which 80% of women experience, including hot flashes, night sweats, mood swings, and weight gain [6][7] - Long-term benefits of HRT include reducing cognitive decline by up to 64% and Alzheimer's risk by 35% in some studies, as well as reducing bone fracture rates [7] Considerations for HRT Use - The 2002 study had flaws, including exclusively studying women who were on average 10 years post-menopause with an average age of 63, a demographic already vulnerable to cardiovascular disease [8] - The study only evaluated one delivery method (a daily pill combining estrogen and progesterone), while delivery methods have improved since then [9] - Contraindications for HRT include a predisposing risk to blood clots or active breast cancer, but these are rare [14] - Doctors generally don't prescribe hormone therapy if you're over age 60 or more than 10 years after the onset of menopause [18] - Estrogen reduces cardiovascular risk in post-menopausal women by 30 to 50% [21]

From @WSJopinion: The FDA’s removal of the black box warning against hormone replacement therapy is an important step toward treating menopause with the same scientific rigor we use in other areas of medicine, writes Marty Makary https://t.co/5E7y8zPL6A ...

Well, today the FDA announced it is scrapping blackbox warnings for many hormone replacement therapy products designed to help women dealing with uncomfortable menopause symptoms. For more than two decades, the American medical establishment turns its back on women. Millions of women were told to fear the very therapy that could have given them strength, peace, and dignity through one of life's most difficult transitions, menopause.that ends today. >> There may be no other medication in the modern era that ...