Wealth & Finance - Larry Ellison's net worth increased by over $110 billion [1] Philanthropy & Investment - Melinda French Gates supports a $100 million partnership focused on women's health [1] News & Events - Charlie Kirk passed away at age 31 due to a shooting incident on Wednesday [1]

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on August 21, 2025 Registration No. 333-289722 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Amendment No. 1 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Femasys Inc. (Exact name of registrant as specified in its charter) Delaware 3841 11-3713499 (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) (I.R.S. Employer Identificat ...

Alzheimer's Research Advocacy - The Women's Alzheimer's Movement advocates for women's brain research [1] - The movement aims to rectify the narrative around Alzheimer's, which previously lacked focus on women [1] Media Mention - Maria Shriver, founder of The Women's Alzheimer's Movement, was featured in ForbesOver50 [1]

Brand & Advocacy - Halle Berry, actress and founder of Respin, advocates for women's menopausal health [1] - Halle Berry believes fighting for women's health is a legacy worth leaving [1] Media Mention - Forbes featured Halle Berry and her advocacy for women's health in ForbesOver50 [1]

TABLE OF CONTENTS Registration No. 333- As filed with the Securities and Exchange Commission on August 19, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 Femasys Inc. (Exact name of registrant as specified in its charter) | elaware | | --- | (State or other jurisdiction of incorporation or organization) (Primary Standard Industrial Classification Code Number) Delaware 3841 11-3713499 (I.R.S. Employer Identificatio ...

Economic Impact of Neglecting Women's Health - The global economy loses over $1 trillion annually due to lost productivity, absenteeism, and healthcare costs related to women's health [7] - US employers lose over $225 billion annually in healthcare costs, significantly driven by delayed diagnoses and lower quality of care for women [7] - Pharmaceutical companies miss out on billions by having only 4% of their pipelines focused on female-only conditions [8] - Consumer health and technology companies lose hundreds of millions by developing solutions based on male-centric data [9] Systemic Issues in Women's Healthcare - Women's health is often an afterthought, a blind spot ingrained in how healthcare views women [5] - Over 80% of autoimmune disease patients are women, yet nearly all research (92%) is conducted on men [3] - Delays in diagnosing and treating women's health issues lead to significant economic and personal costs [2][3][7] - Traditional tests often overlook biomarkers and hormone fluctuations relevant to women's health [11] Opportunities in Women's Health (Femtech) - Reframing the conversation around women's health presents a significant economic and healthcare opportunity, potentially beyond a $500 billion market [6][10] - Femtech companies are creating innovative solutions designed around the entire life cycle and experiences of women [15] - AI and precision medicine can be used to improve drug development and predict sex-specific drug responses [12] Actions for Improvement - Challenge outdated narratives, question dismissive care, and refuse to downplay symptoms [18] - Policymakers, healthcare leaders, and technologists should ensure comprehensive policies and evaluate product development pipelines [19] - Physicians should advocate for more comprehensive medical training and question outdated diagnostic criteria [19]

Menopause & Neuroscience Research - Research indicates menopause is not just a hormonal shift but a neurological upgrade, enhancing problem-solving, leadership, and decision-making skills [12] - A 2017 study showed that post-menopausal women's cognitive performance exceeded their premenopausal levels in verbal memory tasks [13][14] - During perimenopause, cognitive performance may dip but still outperforms men, with the female brain undergoing remodeling to compensate for estrogen decline [14][15][16] Societal & Cultural Perspectives - Society often devalues women post-menopause due to an overemphasis on fertility and youthfulness [18][19] - Certain cultures, like Mayan and Japanese, view menopause with increased respect, authority, and as a renewal of energy [23][24] - Cultural narratives significantly impact the experience of menopause, highlighting the importance of mindset [24][25] Business & Workplace Implications - As of 2025, 1 billion people globally will be going through menopause, representing 25% of the Canadian workforce [19][20] - Companies supporting menopausal women with flexible policies and health benefits report enhanced organizational culture, increased retention, and improved strategic innovation [20][21] - Organizations that fail to recognize and support menopausal women are leaving valuable potential untapped [21][22] Personal Transformation & Empowerment - Menopause can be a liberating experience, freeing women from societal expectations based on fertility and youthfulness [27][28][29] - Post-menopausal women report feeling more creative, decisive, and clearheaded, viewing menopause as a catalyst for prioritizing their own goals [30] - Menopause is a biologically built-in time for women to focus on themselves and pursue their aspirations [31][32][33]

Philanthropy & Investment - Bill Gates Foundation commits $2.5 billion to women's health initiatives [1]

Brand & Advocacy - Halle Berry, actress and founder of Respin, advocates for women's menopausal health [1] - Halle Berry considers fighting for women's health a legacy worth leaving [1] Media Mention - Halle Berry shared why she started Respin and began advocating for women's menopausal health in @mcgrathmag [1] - The news was mentioned in ForbesOver50 [1]

Regulatory Transparency & Flexibility - The FDA emphasizes regulatory flexibility, tailoring processes to specific conditions, especially rare and incurable ones, considering limited alternatives [1][2] - Drug developers and pharmaceutical companies deserve predictability, as highlighted by the framework for COVID vaccine regulation published in the New England Journal of Medicine [4][5] - The FDA aims for transparency by releasing decision letters to the public and drug developers, modernizing the agency, and addressing misinformation, including rewriting dietary guidelines with USDA [12][13] Vaccine & Booster Recommendations - While the CDC sets the vaccine schedule, the FDA has approved vaccines for high-risk populations; booster shots for low-risk individuals require more research [5][6] - There are scientific unknowns and polarizing views regarding the necessity and frequency of COVID boosters, especially for healthy young individuals, alongside concerns about vaccine injuries [8][9] Public Trust & Misinformation - Public trust in health institutions has significantly declined, with trust in doctors and hospitals dropping from 71% to 40% in the last four years, necessitating rebuilding efforts [10][11] - The FDA is addressing misinformation by rewriting the food pyramid with USDA, ending the "war on natural saturated fat," and clarifying the difference between whole grains and ultra-processed foods [13] Food & Dietary Guidelines - The FDA is taking action to remove petroleum-based food dyes, inspired by previous discussions on removing "poisons and chemicals" from the food supply [17][18] - The FDA acknowledges the addictive nature of processed foods, designed by food scientists, contributing to chronic diseases and insulin resistance in children [20][21] - The SNAP program now has waivers for states to restrict taxpayer dollars from being used for junk food and sugary drinks [22] Women's Health - Women's health issues have been historically overlooked, prompting the FDA to host a roundtable on hormone replacement therapy for perimenopausal women [25][26] - The NIH is refocusing its funding to study root causes of chronic diseases, including school lunch programs, sleep medicine, and environmental exposures [29] Opioid Crisis & Supplements - The FDA, along with the DEA, is taking action to schedule 7-hydroxy mitragynine (7-OHM), a synthetic opioid found in vape stores, which is 13 times more potent than morphine [35][36] - The FDA is concerned about the unregulated nature of supplements and the need for regulation to ensure Americans are taking trustworthy and healthy products [33]