Core Insights - Chronic non-communicable diseases such as cardiovascular diseases, diabetes, and respiratory diseases are the leading causes of death in China, with a significant portion of deaths attributed to these conditions [1] - The management of hypertension, hyperglycemia, and hyperlipidemia (the "three highs") is crucial for reducing cardiovascular events, as these conditions are interlinked and pose a high risk for heart failure [1] - There is a pressing need for integrated management of chronic diseases to improve overall patient health and reduce hospitalization and mortality rates [1] Group 1: Cardiovascular and Chronic Diseases - Over 29% of patients have two or more risk factors related to the "three highs," significantly increasing the risk of severe cardiovascular events [1] - Chronic heart failure is a major cause of death from cardiovascular diseases, necessitating strict adherence to management guidelines to mitigate risks [1] - The overlap between chronic heart failure and chronic obstructive pulmonary disease (COPD) complicates patient management and increases hospitalization and mortality risks [2] Group 2: Diabetes and Kidney Disease - More than 40% of chronic kidney disease patients have underlying conditions such as diabetes and hypertension, highlighting the interrelated nature of these diseases [2] - Approximately 80% of diabetes patients die from cardiovascular events, and 20%-40% may develop diabetic nephropathy, indicating the need for comprehensive management strategies [2] - Regular monitoring of kidney function through tests like UACR and serum creatinine is essential for high-risk groups, including those with diabetes and cardiovascular diseases [2] Group 3: Treatment Challenges and Innovations - Current treatment methods for hypertension are inadequate in controlling elevated aldosterone levels, which are a key factor in poor blood pressure management [2] - There is a need for innovative treatment options to address the challenges posed by chronic diseases and their complications [2] - Early identification and diagnosis of conditions like transthyretin amyloid cardiomyopathy are critical for improving patient outcomes and prolonging survival [3]