Core Viewpoint - The latest research published in the journal Cell reveals that skipping breakfast can trigger a "metabolic memory" effect in the small intestine, leading to increased nutrient absorption efficiency and potentially contributing to obesity and atherosclerosis [6][7][9]. Group 1: Mechanisms of Nutrient Absorption - The small intestine operates through two independent nutrient supply pathways: luminal supply (food intake) and blood supply (internal reserves) [8]. - When breakfast is skipped, the small intestine shifts to an internal energy supply mode, activating a "metabolic compensation mechanism" that enhances nutrient absorption efficiency, particularly for cholesterol and fats [8][9]. - In mouse models simulating breakfast skipping, significant metabolic reprogramming occurs, including a nearly 40% increase in cholesterol absorption efficiency due to upregulation of key transport proteins [9][18]. Group 2: Consequences of Skipping Breakfast - Long-term skipping of breakfast leads to a "rebound absorption" effect, resulting in increased weight gain and metabolic disorders [13][15]. - Mice that regularly skip breakfast show elevated low-density lipoprotein cholesterol (LDL-C) levels, exacerbating lipid metabolism disorders and doubling the risk of atherosclerosis [18]. Group 3: Recommendations for Metabolic Health - Attempting to lose weight through hunger may backfire, as the small intestine's "super compensation" can lead to greater fat accumulation upon subsequent intake [15]. - Regular breakfast consumption, particularly with a combination of protein and dietary fiber, can effectively reset absorption rhythms and stabilize metabolism [15].