内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 以下文章来源于内分泌早知道 ，作者关注内分泌的 减肥人群中盛行着这样的晨间对话： "跳过早餐吧，空腹状态能加速脂肪燃烧！" 这种看似科学的减重策略究竟是否可靠？国际顶级期刊Ce ll发布的最新研究给出了颠覆性结论。由科研团队开展的《双营养供应模式下 小肠对营养吸收与宿主防御的差异化调控机制》研究表明，晨间饥饿状态将引发小肠的"代谢记忆效应"——这个被低估的消化器官不仅 具备精密调控能力，更会通过增强营养吸收效率来应对禁食期。 - 长期"代谢记忆"：即使恢复规律饮食，小肠仍维持高吸收状态，表观遗传调控的改变使相关基因持续活跃。 ▍早餐缺失触发小肠"报复性吸收"：Ce ll研究揭示饥饿如何加剧肥胖与动脉硬化 许多人误以为小肠仅仅是消化系统中的一个简单通道，但最新科学研究表明，它更像是一个高度智能的"代谢调控中心"。它不仅负责营 养吸收，还参与免疫调节和肠道微生态平衡。然而，当早餐被刻意跳过时，这个精密系统会启动一种令人意外的"代谢记忆"机制，最终 导致越饿越胖，甚至加速动脉粥样硬化的进程。 小 ...

Core Viewpoint - The article emphasizes the detrimental effects of prolonged sedentary behavior on both physical and cognitive health, highlighting the urgent need for integrating movement into daily routines to combat metabolic disorders and cognitive decline [8][11][15]. Group 1: Sedentary Lifestyle and Health Risks - A study reveals that just 10 days of inactivity can significantly worsen insulin resistance and increase the risk of cognitive decline through muscle-brain axis disruptions [8][9]. - Data indicates that from 1940 to 2020, while global life expectancy increased by 12.6 years, the prevalence of type 2 diabetes surged by 4.7 times, and healthy life expectancy after age 65 decreased by 8.2 years [11][12]. - Urban professionals are reported to sit for over 9 hours a day, with 83% relying on screens during leisure time, contributing to metabolic crises [14]. Group 2: Mechanisms of Cognitive Decline - Muscle disuse leads to iron overload in skeletal muscles while decreasing iron levels in serum and brain tissue, creating a negative correlation that exacerbates insulin resistance and neuroinflammation [8][9]. - The study identifies a new mechanism where muscle atrophy affects cognitive decline through iron metabolism regulation, suggesting that even short-term inactivity could be a potential trigger for Alzheimer's disease [9]. Group 3: Benefits of Physical Activity - Engaging in regular physical activity can yield immediate and long-term health benefits, including a 33% reduction in all-cause mortality risk for those who incorporate movement into their routines [16][17]. - The concept of "exercise investment" is introduced, indicating that the metabolic memory effect from exercise can sustain pancreatic and brain health, making any time to start exercising worthwhile [16][17]. - Regular exercise can enhance insulin sensitivity by 25% and reduce dementia risk by 28% compared to sedentary individuals [16][17]. Group 4: Strategies for Incorporating Movement - The article suggests four simple strategies to develop exercise habits, such as creating more opportunities for activity in daily life, incorporating short breaks for movement during work, engaging in outdoor activities on weekends, and setting achievable goals [18][19]. - Small changes, like walking an additional 2,000 steps daily, can significantly lower cardiovascular disease risk by 15% [18]. - Establishing a consistent exercise routine is emphasized as more important than the intensity of workouts, with gradual increases in activity recommended [19].

Core Insights - The recent academic conference on endocrine metabolic diseases highlighted the importance of integrated continuous glucose monitoring (iCGM) technology for diabetes management, emphasizing its role in improving patient outcomes and reducing complications [1][2] Group 1: iCGM Technology and Standards - The iCGM technology represents international high standards for blood glucose monitoring, allowing integration with other medical devices for insulin dosage adjustments [1] - The iCGM standard includes strict requirements across 11 performance indicators, establishing it as the gold standard for glucose monitoring [1] - The National Medical Products Administration of China has introduced iCGM classification and standards, raising accuracy and stability requirements for CGM in the country [1] Group 2: Diabetes Complications and Management - Diabetes complications can lead to severe health issues, including a 1.5-2.5 times increased risk of coronary heart disease and stroke [1] - Early and strict blood sugar control can create a "metabolic memory" effect, significantly lowering the risk of complications such as diabetic kidney disease and retinopathy [1] - A comprehensive blood sugar management approach is necessary, integrating both hospital treatment and outpatient care [2] Group 3: Real-World Research Findings - The REFLECT real-world study indicates that using continuous glucose monitoring systems can significantly reduce hospitalization risks for cardiovascular complications in diabetes patients [2] - For type 1 diabetes patients with a history of severe hypoglycemia, hospitalization rates related to cardiovascular diseases decreased by 78% [2] - Adult type 2 diabetes patients also experienced a reduction in hospitalization rates for cardiovascular complications [2]