Core Points - The planned sixth round of nuclear talks between the US and Iran was disrupted by a large-scale attack by Israel on Iranian targets, including nuclear facilities and military leaders [1][2] - Israel's Prime Minister Netanyahu stated that the preemptive action was necessary due to Iran's rapid advancements in nuclear weapons development [1][2] - The attack resulted in significant losses for Iran, including key military and nuclear figures, which could severely impact Iran's military command structure and nuclear program [4][8] Group 1: Attack Details - Israel launched an operation named "Strength of a Lion," involving 200 aircraft and approximately 330 bombs targeting over 100 sites across Iran [2][8] - The operation was more intense than previous military actions and included targeted assassinations of high-ranking military officials and nuclear scientists [2][4] - Key figures lost in the attack included the commander of the Islamic Revolutionary Guard Corps and the chief of staff of the Iranian armed forces, both crucial to Iran's military strategy [5][6] Group 2: Iranian Response - Iran condemned the attack as an act of war and vowed to retaliate without restrictions, launching over 100 missiles and drones towards Israeli cities [2][8] - The Iranian leadership, including Supreme Leader Khamenei, warned of severe consequences for Israel, although many of the retaliatory strikes were intercepted [2][8] Group 3: Impact on Nuclear Negotiations - The attack has led Iran to declare the ongoing nuclear negotiations with the US as "meaningless," effectively collapsing the trust necessary for dialogue [10][17] - The US, while not directly involved in the attack, expressed prior knowledge and support for Israel's actions, further straining US-Iran relations [2][11] - Analysts suggest that the prospects for a nuclear deal are now bleak, with Iran potentially moving towards overt nuclear militarization [9][17]