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湘雅团队最新研究发现,腺苷有望成为银环蛇咬伤急救新选择
生物世界· 2025-06-15 09:30
Core Viewpoint - The research highlights the potential of adenosine, derived from the traditional herb "异叶茴芹," as a promising early intervention for silver ring snake envenomation, showing significant protective effects in animal models [4][10]. Group 1: Research Findings - The study published in the Journal of Advanced Research demonstrates that adenosine can achieve a 100% survival rate in mice injected with silver ring snake venom when administered intraperitoneally at a dose of 25 mg/kg [4][10]. - Adenosine effectively mitigates the neuro-muscular blockade caused by the snake venom, preserving acetylcholine receptor function and maintaining normal respiratory muscle activity [8][10]. - The research identifies ten major compounds from the herb, with adenosine being particularly effective against silver ring snake venom [6][10]. Group 2: Clinical Implications - Adenosine is a naturally occurring substance in the human body and has been approved for clinical use in treating other conditions, indicating a clear safety profile [10]. - The study emphasizes the need for exploring more convenient administration methods for adenosine, especially in emergency field scenarios, to enhance its practical application [10]. - Future research will involve validating the detoxifying effects of adenosine in larger animal models and developing suitable clinical emergency administration protocols [10].