Core Insights - The international brain laboratory has published a groundbreaking study in *Nature*, creating the first high-resolution neural activity map of the entire mouse brain throughout the decision-making process, which enhances understanding of how the brain makes decisions and introduces a new paradigm in international neuroscience research [1][2] Research Methodology - The study involved 12 renowned neuroscience research teams globally, utilizing a standardized experimental paradigm across different laboratories, where mice performed a visual choice task to receive a reward [2] - A total of 139 mice underwent 699 electrode insertions, covering 279 anatomically defined brain regions, recording approximately 622,000 neurons' firing activities, resulting in a dynamic, panoramic "whole-brain neural activity map" [2][3] Findings on Neural Activity - The research revealed that during tasks, the mouse brain exhibits a "city-wide illumination" style of coordinated activation, with visual stimuli triggering local activation that rapidly spreads across the brain, indicating that decision-making involves multiple neural nodes interacting within milliseconds [3] - The findings suggest that decision-making is not confined to higher brain regions like the prefrontal cortex but involves synchronous activity across various brain areas, highlighting a decentralized approach to cognitive functions [3] Implications for Neuroscience - This study implies that many neuropsychiatric disorders may not stem from damage to a single brain area but rather from imbalances in large-scale neural network coordination, suggesting future treatment strategies may shift from "point repair" to "network regulation" [3][4] - The research also emphasizes the need for further studies to establish causal relationships and to explore brain activity in freely behaving subjects, aiming to create a comprehensive "digital twin" of the brain [4] Collaborative Research Model - The organization of this research exemplifies high levels of collaboration, with 12 laboratories functioning like different brain regions, working under unified standards to achieve scientific breakthroughs beyond the capabilities of individual teams [4]