一场主题为"AI时代的音乐科技与健康"的跨学科盛宴——大圆镜科普系列第一讲，11月17日在上海音乐 学院歌剧院举行。音乐、人工智能、神经科学与医学领域的专家与艺术家共聚一堂，探讨当算法理解旋 律、当声音触及大脑，AI如何重塑艺术边界，并为人类身心健康谱写全新的乐章。 上海音乐学院教授谭盾携众多艺术家在朱家角水乐堂上演"天顶上的一滴水"现场音乐会。 AI赋能音乐守护身心健康 "音乐不仅是艺术语言，更成为重要的疗愈方式。在AI技术飞速发展的今天，音乐艺术、医疗、脑科 学、人工智能专家的跨界合作，用音乐来造福患者，守护身心健康，前景广阔"，在活动现场，天桥脑 科学研究院创始人雒芊芊介绍旗下科学传播品牌"大圆镜科普"，围绕脑科学、人工智能等前沿科技话 题，以深入浅出的语言和精美的AIGC视频展现，帮助公众了解科技，拥抱未来。 作曲家、指挥家，上海音乐学院教授、博士生导师谭盾以"左耳朵听西方，右耳朵听东方"的个人体验为 引，生动阐述其创作中东西方文化的交融与碰撞，并现场展示使用到人工智能技术的项目成果之一： 《声音河流》，通过全景声、虚拟现实等技术，将田野调查中采集的、濒临消失的"声音丝绸之路"上的 乐器与故事，与交响 ...

Core Points - The event "Bridging Mountains and Seas, Mutual Learning" focused on the Chinese connection of Dr. Pei Dele, held in Havana, Cuba, where over 150 guests witnessed the signing ceremony for the Spanish version of the book "Pei Dele's Chinese Story" and watched the documentary "Cuban Heart, Chinese Feelings" [1][3][5] Group 1 - The event was attended by Chinese Ambassador to Cuba, Hua Xin, who emphasized the deepening of Sino-Cuban relations over 65 years, highlighting Dr. Pei Dele as a model for scientific collaboration [3][5] - The President of the Cuban Biotech and Pharmaceutical Industry Group, Maida Mauri Perez, noted that Dr. Pei Dele's work has introduced new technologies to Cuba's healthcare system, with significant implications beyond national borders [3][5] - Luis Velasquez Perez, President of the Cuban Academy of Sciences, stated that Dr. Pei Dele has built a bridge connecting the scientific communities of both countries, enabling them to tackle global challenges together [3][5] Group 2 - A memorandum of cooperation was signed between the University of Electronic Science and Technology of China and the Cuban Information Technology and Advanced Remote Services Company to promote the publication of the Spanish version of Dr. Pei Dele's book and the airing of the documentary on Cuban national television [5] - The event was co-hosted by multiple organizations, including the State Council Information Office of China and the Cuban Neuroscience Center, showcasing the collaborative efforts in science and technology between the two nations [5] - Dr. Pei Dele, a prominent neuroscientist and co-founder of the Cuban Neuroscience Center, has made significant advancements in brain science research and talent development since joining the University of Electronic Science and Technology of China in 2015 [5]

Core Viewpoint - Brain-computer interface technology is transforming science fiction into reality, enabling individuals with disabilities to regain grasping abilities and allowing for high-precision decoding of neural signals for "thought reading" [1] Group 1: Technological Advancements - The Tianjin University neuroengineering team has focused on non-invasive brain-computer interfaces, achieving significant breakthroughs over more than a decade of research [1] - Key developments include the creation of artificial neural robotic systems and human-machine collaboration in extreme environments [1] Group 2: Clinical Application and Innovation - The transition from scientific exploration to clinical application reflects the integration of disciplines and the responsibility of researchers [1] - The Liu Xiuyun team is addressing diagnostic challenges in brain diseases by merging cutting-edge brain science research with clinical needs, creating a comprehensive system for "diagnosis-monitoring-treatment-prediction" [1] Group 3: Future Prospects - The reciprocal relationship between advanced technology and medical practice highlights the power of innovation in safeguarding public health [1] - There is an expectation for more cutting-edge technologies to accelerate their implementation, benefiting the lives of the general public [1]

Group 1 - Jiangsu University is recognized as one of the first high-level universities in the province, with a focus on historical development, technological innovation, and international cooperation [2] - The university emphasizes the importance of the "14th Five-Year Plan" period for achieving socialist modernization and encourages students to enhance their sense of responsibility and mission [2] - Jiangsu University has a distinctive educational approach that integrates engineering with agriculture, aiming to cultivate talent for national development [2] Group 2 - Huichuang Medical Company specializes in brain science research and is positioned to benefit from the strategic goal of significantly improving technological self-reliance during the "14th Five-Year Plan" [3] - The company is encouraged to explore cutting-edge technologies and contribute to public health, with support from provincial and municipal departments to address practical challenges [3] - Wode Agricultural Machinery Company is recognized for its efforts in agricultural modernization and is urged to leverage local educational and industrial resources to innovate in smart and green agricultural technologies [3]

Group 1 - Jiangsu University is recognized as one of the first high-level universities in the province, emphasizing the importance of education and technology in achieving national development goals [2] - The university has a long history and a distinctive focus on integrating engineering with agriculture, which aligns with the strategic goals set for the next five years [2] - The university is encouraged to foster a sense of responsibility among students to contribute to the country's technological self-reliance and innovation [2] Group 2 - Huichuang Medical Company specializes in brain science research and is positioned to benefit from the national strategy aimed at enhancing technological self-reliance during the 14th Five-Year Plan [3] - The company is urged to explore cutting-edge technologies and address practical challenges with the support of local government [3] - Wode Agricultural Machinery Company is recognized for its efforts in modernizing agriculture through technology and is encouraged to innovate in smart and green agricultural machinery [3]

Core Insights - The research conducted by scientists at MIT reveals that the ability to detect subtle changes in visual information relies on a low-frequency brain wave known as theta wave [1][2] - Theta waves function like a radar, scanning the visual cortex to "read" information in visual working memory, which is crucial for short-term recognition of changes [1] Group 1: Research Findings - The study involved an animal experiment designed as a "find the difference" task, where animals had to quickly identify a color change in a set of colored blocks [1] - The accuracy and speed of the animals' responses were closely linked to the phase of theta waves, indicating a rhythmic fluctuation in the brain's processing of visual working memory [1][2] - When the color-changing block appeared in the area being scanned by theta waves, the animals responded most quickly and accurately; mismatched timing led to a significant decline in recognition performance [1] Group 2: Mechanisms of Brain Function - Theta waves not only correlate with response speed but also coordinate other brain wave activities, such as suppressing beta wave activity during theta wave excitation [2] - This inter-wave coordination mechanism helps explain how the brain utilizes different frequency brain waves to perform cognitive operations [2] - The influence of theta waves becomes more pronounced as the number of blocks to remember increases, suggesting that theta waves may limit the capacity of working memory [2]

Core Insights - Chinese scientists have made significant progress in brain mapping research, with 10 studies published in international journals, including "Cell" and "Neuron," showcasing advancements in understanding brain structure and function [1][2][3] Group 1: Research Achievements - The "Whole Brain Mesoscopic Neural Connectivity Atlas" project aims to create detailed brain maps of non-human primates and humans, addressing the complexity of mammalian brains, which contain nearly 100 billion neurons and over 100 trillion connections [2][3] - A team of over 300 researchers from more than 30 institutions has successfully completed studies that analyze brain cell diversity, connectivity patterns, and molecular mechanisms of brain diseases, enhancing China's international influence in this field [2][3][6] - The research includes the first high-resolution evolutionary atlas of 1.3 million brain cells from various species, revealing key gene evolution related to differences in brain cell types across species [3][12] Group 2: Technological Innovations - The development of specific genetic tools for primate brain research allows for precise delivery of functional proteins to targeted cells, potentially enabling targeted therapies for brain diseases [4][5][25] - A new collection of tools for specific labeling and observation of primate brain cells has been established, marking a significant advancement in understanding brain structure and diseases [4][25][30] Group 3: Collaborative Efforts - The establishment of the "International Primate Mesoscopic Brain Atlas Alliance" aims to enhance global collaboration in brain mapping research, with a focus on creating a shared database for brain atlas data [9][32] - The research integrates contributions from various international institutions, highlighting the collaborative nature of modern neuroscience research [9][32] Group 4: Future Directions - The goal is to complete the mesoscopic neural connectivity atlas for mice by 2025 and for macaques by 2035, indicating a long-term commitment to advancing brain mapping technologies [8][9] - Continued development of imaging and labeling technologies is essential for achieving high-quality brain maps, which are crucial for understanding complex brain functions [14][15]

Group 1 - The core achievement of the research is the development of a three-dimensional reconstruction of 2,231 projection neurons in the macaque prefrontal cortex, revealing a "streamlined and efficient" connectivity pattern akin to a precise circuit for modular information processing [1] - The research team from the Chinese Academy of Sciences has developed an imaging system capable of completing whole-body subcellular resolution imaging of adult mice in 40 hours, clearly presenting the projection pathways of peripheral nerve fibers [1] - A new cell-type-specific targeting tool for primate brain research has been developed, overcoming transgenic limitations and marking a new stage in precise cell type analysis in macaque brains [1] Group 2 - The "Whole Brain Mesoscopic Neural Connectivity Atlas" project aims to create a comprehensive research system from circuit analysis to disease decoding, with a focus on mapping the mesoscopic brain atlas of non-human primates [2] - An international primate brain atlas research alliance is being established to integrate multinational technological resources and create a shared database, ultimately aiming to "understand, simulate, and protect the brain" [2] - The research team is continuously optimizing surgical techniques for macaque brain injections, which require precise navigation to avoid blood vessels and functional areas, highlighting the complexity and dedication involved in the procedures [2] Group 3 - The Chinese Brain Project aims to conduct large-scale foundational research while also addressing major societal needs through the diagnosis and treatment of brain diseases, as well as developing brain-machine interfaces and brain-inspired artificial intelligence [3] - The recent breakthroughs in brain mapping technology are expected to clarify brain structures and inspire research in brain-like intelligence [4] - A global open-access brain atlas database has been established, integrating cross-species cell atlases, neural connectivity maps, and multimodal dynamic data, which will support future understanding of human brain functioning and the development of next-generation brain-inspired AI [4]

Core Insights - A team led by Chinese researchers is attempting to create a high-resolution "brain atlas" at the single-cell level, a significant advancement in neuroscience [1][3] - The research has resulted in ten series of achievements in mesoscopic brain mapping, published in a special issue of the journal "Cell" [1][4] Group 1: Research Achievements - The research has successfully transitioned from rodent models to primate models, highlighting the complexity of primate brains compared to rodents [3][4] - One article published in "Cell" details the whole-brain projection map of single neurons in the prefrontal cortex of macaques, which is crucial for higher cognitive functions [4] - Another article focuses on the striatum, a brain region potentially linked to consciousness, revealing significant structural and cellular type differences between macaques and rodents [4] Group 2: Technological Innovations - The research is supported by advanced autonomous technologies, including cell type analysis and neural connectivity mapping, which are essential for understanding cellular changes in diseases [4] - The imaging and morphological reconstruction technologies enable high-resolution imaging of the entire brain and facilitate high-throughput, rapid data analysis [4] Group 3: Collaborative Efforts - The series of achievements involved over 300 contributors from both domestic and international backgrounds, showcasing the capability for global collaborative research [5] - The complexity and data volume of primate brain mapping necessitate ongoing global scientific cooperation to achieve higher goals in understanding the mesoscopic brain atlas [5]

Core Viewpoint - The article discusses a groundbreaking study that presents a mouse brain stereotaxic topographic atlas with isotropic 1 μm resolution, which is expected to enhance multi-omics research at the single-cell level in neuroscience [3][6][8]. Group 1 - The research team, including academicians from Hainan University, Huazhong University of Science and Technology, and UCLA, published their findings in the journal Nature, detailing a 3D brain atlas for mice [3]. - The atlas, named STAM, provides a comprehensive dataset of 916 brain structures and allows for the generation of high-resolution images at any angle [6][8]. - The study utilizes continuous micro-optical sectioning imaging technology to create a dataset based on Nissl staining, achieving isotropic 1 μm resolution [6]. Group 2 - The STAM atlas is designed to support large-scale brain mapping projects by providing data analysis and visualization capabilities [8]. - It includes an informatics platform for visualizing and sharing atlas images, facilitating tasks such as brain slice registration and neuron circuit mapping [6]. - The atlas is compatible with widely used stereotaxic atlases, enabling cross-atlas navigation in both 2D and 3D spaces [6].