Core Viewpoint - The 2025 list of prohibited substances has been officially released, including 400 types of drugs, with 9 new additions compared to 2024 [2] Group 1: New Additions to the Prohibited List - Anabolic agents: 95 types (no new additions) [3] - Peptide hormones: 75 types (2 new additions) [3] - Narcotic drugs: 14 types (no new additions) [3] - Stimulants (including psychoactive drugs): 84 types (2 new additions) [3] - Precursor chemicals: 3 types (no new additions) [3] - Medical toxic drugs: 1 type (no new additions) [4] - Other drugs: 128 types (5 new additions) [4] Group 2: Specific New Drugs - The 2 new peptide hormones are: - S519 (No. 159) [6] - S597 (No. 160) [6] - The 2 new stimulants are: - Midodrine (No. 241) [7] - Tisofenacin (No. 265) [7] - The 5 new drugs in the "Other" category are: - Elagolix (No. 323) [7] - MOTS-c (No. 351) [7] - S-107 (No. 375) [7] - S48168 (No. 376) [7] - Hipamine (No. 400) [7] Group 3: Clarification on Semaglutide - Recent claims that Semaglutide is a stimulant are inaccurate, as it is not listed in the 2025 directory [7] - Semaglutide is classified under GLP-1 receptor agonists, which are not included in the 2025 directory [8] - The only related substance in the directory is IGF-1 (Insulin-like Growth Factor 1), which is different from GLP-1 [8] - Semaglutide remains under monitoring programs to observe its impact on athletes, consistent with 2024 arrangements [8]

Core Viewpoint - The 2025 list of prohibited substances has been officially released, including 400 types of drugs, with 9 new additions compared to 2024 [2] Group 1: New Additions to the Prohibited List - The new additions include 2 peptide hormones and 2 stimulants, while other categories have seen various changes [3][4] - The two new peptide hormones are S519 and S597 [6] - The two new stimulants are Midodrine and Tesofensine [7] - Five new drugs have been added under the "Other Drugs" category, including Elagolix and MOTS-c [7] Group 2: Clarification on Semaglutide - Recent claims that Semaglutide is classified as a stimulant are inaccurate, as it is not listed in the 2025 directory [7][8] - Semaglutide is a GLP-1 receptor agonist, and the directory does not include GLP-1 or its analogs [8] - The only related substance in the directory is IGF-1, which is fundamentally different from GLP-1 [8] - Semaglutide remains under monitoring programs to observe its impact on athletes, consistent with 2024 arrangements [8] Group 3: Industry Context - The GLP-1 drugs are a new class of hypoglycemic agents that enhance insulin secretion and suppress appetite, leading to weight loss and blood sugar reduction [15]