Core Insights - The article highlights five significant research papers published in the journal Cell, with four originating from Chinese scholars, focusing on advancements in DNA sensors, anti-aging potential through protein restriction, new antidepressant molecules, and cancer cell immune evasion mechanisms [3]. Group 1: SARM1 and DNA Sensing - The research from Dalian Medical University reveals that SARM1 can sense double-stranded DNA (dsDNA) and induce cell death by degrading NAD+ in a sequence-independent manner [5][6]. - SARM1's interaction with dsDNA is crucial for its activation, and its gene knockout can prevent chemotherapy-induced neuropathy in mice [5][6]. Group 2: Protein Restriction and Aging - The study from West Lake University presents a comprehensive proteomic landscape of aging, showing that protein restriction can reshape the protein expression and epigenomic states associated with aging [9][10]. - The findings suggest that midlife is the optimal period for protein restriction interventions, which are linked to improved cardiovascular health and reduced inflammation risks [9][10]. Group 3: Norepinephrine Transporter and Antidepressants - Research from Lingang Laboratory identifies conformation-selective regulatory mechanisms of the norepinephrine transporter (NET) and proposes a new inhibitor recognition mechanism [14]. - The study led to the discovery of a small molecule with antidepressant activity, providing a structural basis for understanding NET and other monoamine transporters [14]. Group 4: Cancer Cell Immune Evasion - The research from Fudan University reveals that cancer cells can exploit inter-organ neuroimmune circuits to evade immune surveillance by activating pain-sensing neurons [18][20]. - This mechanism involves the secretion of SLIT2, which enhances tumor-associated macrophage polarization towards a pro-tumor state, thereby promoting tumor growth and reducing the efficacy of immune checkpoint blockade therapies [18][20]. Group 5: Coronavirus Replication Mechanisms - A study from Tsinghua University elucidates the molecular mechanisms of RNA template recycling and capping in SARS-CoV-2, resolving long-standing debates in the field [23][24]. - The research captures critical pre-capping and post-capping initiation states, enhancing the understanding of RNA virus transcription and replication processes [23][24].