Core Insights - The research conducted by German scientists reveals that "trapped water" in specific structures can influence the surrounding environment and facilitate molecular interactions, potentially paving the way for new drug and material development [1][2]. Group 1: Research Findings - The study identifies the phenomenon of "high-energy water," which exists in confined spaces and exhibits energy states higher than ordinary water, impacting molecular binding processes [1][2]. - The research utilized cucurbituril as a "host" molecule, demonstrating that high-energy water molecules are crucial driving forces in molecular binding, with higher energy levels favoring the binding of guest molecules [2]. Group 2: Implications for Medicine and Materials Science - In drug design, recognizing high-energy water in target proteins can aid in the systematic design of active molecules that can replace this water, enhancing drug efficacy by anchoring more firmly to proteins [2]. - In materials science, designing cavities that can expel or replace high-energy water may improve the sensing and storage capabilities of materials [2].