随着年龄的增长，患癌症、心脏病和痴呆症等严重疾病的风险会显著增加。多年来，研究人员一直在分别应对这些疾病。如今，许多科学家开始退一步 思考一个更广泛的问题—— 与其逐一治疗疾病，减缓衰老过程是否能够同时降低患多种疾病的风险 （尤其是年龄相关疾病） ？要回答这个问题，首先 需要了解是什么引发了伴随年龄增长而出现的生物学变化。 系统性表征最易衰老的细胞状态及其潜在的遗传和表观遗传变化，对于确定治疗靶点以指导抗衰老干预措施至关重要。 近年来的单细胞研究对细胞状 态和群体结构中衰老相关改变进行了表征，但它们常常忽略了塑造此类动态的非编码调控程序。尽管基于 ATAC-seq 的单细胞分析， 通过绘制衰老过 程中细胞类型特异性的染色质变化， 填补了这一空白，，但大多数研究仅限于少数几个器官，这使得在整个生物体范围内的推断存在空白。 撰文丨王聪 编辑丨王多鱼 排版丨水成文 20 26 年 2 月 26 日，洛克菲勒大学 曹俊越 团队与 周伟 团队合作 （ 博士生 卢梓育 为论文第一作者 ） 在国际顶尖学术期刊 Science 上 发表了题 为： Organism-wide cellular dynamics and epi ...

Core Viewpoint - The article highlights the achievements of prominent scientists awarded the Tengchong Science Prize, emphasizing their contributions to various fields of science and technology, particularly in quantum physics, biomedicine, and genetic research [3][7][10][12][15][17]. Group 1: Tengchong Science Prize - The Tengchong Science Prize was awarded for the first time in 2023, with recipients including Professors Lu Yuming and Zhang Feng [8]. - In 2024, the awardees were Professors Xue Qikun and Xie Xiaoliang [8]. - The prize is notable for being the first science and technology award initiated in mainland China with a single prize amount of 10 million RMB, focusing on significant breakthroughs in various scientific fields [17]. Group 2: Notable Awardees - Academician Pan Jianwei received the Tengchong Science Prize for his pioneering work in quantum optics and quantum information, making global secure quantum communication a feasible reality [3]. - Academician Xue Qikun's team discovered the quantum anomalous Hall effect, marking a significant experimental observation in physics [10]. - Academician Xie Xiaoliang is recognized for his foundational work in single-molecule biophysical chemistry and advancements in genome amplification technology, benefiting thousands of families with genetic disorders [12]. - Professor Lu Yuming is acknowledged as a pioneer in non-invasive prenatal testing, revolutionizing prenatal diagnostics and benefiting millions of pregnant women globally [15]. - Professor Zhang Feng is a leading figure in CRISPR-Cas gene editing technology, significantly impacting life sciences and molecular diagnostics [17]. Group 3: Tengchong Young Scientist Award - The Tengchong Young Scientist Award was established this year, covering ten subfields including mathematics, physics, materials science, and ecology [7]. - Notable recipients include Professor Wang Jianwei from Peking University and Professor Qian Xiaoshi from Shanghai Jiao Tong University, among others [7].