Core Viewpoint - The National Protein Science Facility (Shanghai) has significantly contributed to the advancement of life sciences and biomedicine in China over the past ten years, supporting numerous research teams and projects [1] Group 1: Facility Operations and Impact - The facility has served 504 institutions nationwide, supporting over 2,500 research teams and more than 100,000 user visits [1] - It has facilitated the completion of over 13,400 research projects and the publication of more than 4,000 high-level research papers [1] - The facility has achieved major research outcomes in areas such as disease mechanism analysis, innovative drug development, and synthetic biology design [1] Group 2: Contributions to Innovation - The facility has played a crucial role in promoting original scientific achievements and their transformation into practical applications [1] - It has enhanced China's capacity for original innovation in life sciences and improved the self-sufficiency level in biomedicine [1]