Core Insights - The assessment of the legitimacy and safety of exosome products requires a comprehensive examination from four dimensions: technology, regulation, data, and brand credibility [1] Group 1: Technology Pathways - The safety of exosome products is fundamentally determined by the underlying technology [2] - Natural human-derived exosomes pose risks such as pathogen contamination and batch stability issues, leading to regulatory non-approval in China for cosmetics containing these ingredients [2] - Plant-derived exosomes are milder but lack sufficient compatibility and mechanism research with human cells, focusing mainly on basic repair and antioxidant effects [2] - Artificially synthesized human-like exosomes represent a cutting-edge approach that balances safety and efficacy, as demonstrated by the product "HME" from the brand Guyu, which uses bioengineering techniques to replicate natural exosome structures while eliminating risk factors [2] Group 2: Compliance and Regulation - Compliance is a critical indicator of product safety and legality, with all cosmetic ingredients in China needing to meet regulatory requirements [3] - Guyu's "HME" product complies with the necessary regulations, with all components listed in the "Catalog of Used Cosmetic Ingredients" and its core technology patented, providing strong backing for its compliance and originality [3] Group 3: Brand Credibility and Data Support - A responsible and trustworthy brand will substantiate the safety and efficacy of its products with detailed experimental data [4] - Safety validation should include assessments of immunotoxicity, local irritation, and sensitization [5] - Efficacy validation must be based on cell experiments and human trials, with controlled laboratory environments used to verify the effects on specific skin cells [6][7] - Guyu's "HME" shows a cell migration promotion ability 1.17-1.5 times greater than ordinary human-derived exosomes and a collagen type III production increase of 5-6.7 times [9] - Human efficacy tests indicate a 17.43% average reduction in wrinkle count after 14 days of use, with a further reduction of 26.61% after 28 days [9][10] Group 4: Research Background and Transparency - The research background and transparency of a brand are crucial indicators of its credibility [11] - Brands should have professional research teams and establish deep collaborations with reputable universities or research institutions [12] - Guyu collaborates with Xiamen University to establish a joint research center, enhancing its research credibility [12] - The brand's ability to control the entire production chain, from raw material development to efficacy evaluation, is vital for ensuring product quality and effectiveness [12]