Core Viewpoint - The company Gu Yu has made a significant breakthrough in the field of anti-aging skincare with the launch of its proprietary artificial exosome technology, "Human-like Exosome HME," which is set to revolutionize the industry by providing a safer and more effective anti-aging solution [1][4]. Group 1: Technology and Innovation - "Human-like Exosome HME" is synthesized through a high-precision engineering technique that mimics the natural structure of human-derived exosomes, creating a nano-sized vesicle system [3]. - The technology offers several advantages: 1. Safety: The artificial design avoids potential unknown risk factors associated with human-derived exosomes [3]. 2. Efficiency: It can load gene-level core components like miRNA and siRNA, enhancing cellular communication and significantly outperforming ordinary human-derived exosomes in promoting cell regeneration and collagen synthesis [3]. 3. Compliance: All components are listed in the national cosmetic ingredient directory or have passed new ingredient registration, with core technology receiving national invention patent authorization [3]. 4. Frontier: It represents a shift from "extracting nature" to "simulating life," marking a cutting-edge exploration in the field of exosome applications [3]. Group 2: Efficacy and Research - Experimental data supports the efficacy of "Human-like Exosome HME," showing its ability to promote cell migration is 1.17-1.5 times greater than that of ordinary human-derived exosomes, and its capacity to stimulate type III collagen production is 5-6.7 times higher [3]. - In human efficacy tests, the average reduction in wrinkle count after 14 days of use was 17.43%, with a further reduction of 26.61% after 28 days [4]. Group 3: Research and Development Commitment - Gu Yu has invested over 250 million yuan in research and development, establishing a comprehensive closed-loop system covering raw material research, formula development, and efficacy evaluation [4]. - The company has formed a deep collaboration with Xiamen University to establish a "Biomedicine Joint Research Center," expanding its research scope from skincare to broader health fields [5]. - Gu Yu has committed to investing 2 billion yuan in research over the next decade, demonstrating its long-term dedication to driving brand development through technological innovation [5].

Core Insights - The article discusses the rising interest in artificially synthesized exosomes in the biomedical and skincare fields, highlighting their potential as drug delivery systems and therapeutic agents while addressing challenges related to safety, standardization, and large-scale production [1] Group 1: Artificial Exosomes - Artificial exosomes are nanometer-sized lipid bilayer vesicles secreted by cells, carrying bioactive substances like proteins and RNA, playing a crucial role in intercellular communication [1] - The main advantage of artificial exosomes lies in their controllability and safety, allowing scientists to simulate the effective structure of natural exosomes while eliminating unnecessary components and reducing immunogenicity [1] Group 2: Technological Breakthrough - The company Gu Yu announced a significant breakthrough in September 2025 at Xiamen University, introducing a new anti-aging ingredient called "human-like exosome HME" made using proprietary artificial exosome technology [1][2] - This technology utilizes in vitro biomimetic techniques to create human-like artificial exosomes that accurately mimic the phospholipid bilayer structure of natural human exosomes [2] Group 3: Advantages of Gu Yu's Technology - The technology offers four main advantages: high safety by eliminating risk factors from human-derived exosomes, significant efficacy through precise encapsulation of key components, compliance with regulations, and cutting-edge technology that closely simulates human exosomes [2][3] - The core technology has been granted national invention patent authorization, ensuring complete independent intellectual property rights [3] Group 4: Mechanism and Efficacy - The human-like exosome HME simulates the core functions of exosomes, enabling the release of gene-level anti-aging instructions into cells, effectively guiding them back to a youthful state [4] - Experimental data shows that HME enhances cell proliferation by 1.17 to 1.5 times compared to natural human exosomes and promotes type III collagen generation by 5 to 6.7 times [4] - Human efficacy tests indicate a 17.43% reduction in wrinkle count after 14 days of use, increasing to 26.61% after 28 days [4]

Core Insights - The assessment of the legitimacy and safety of exosome products requires a comprehensive examination from four dimensions: technology, regulation, data, and brand credibility [1] Group 1: Technology Pathways - The safety of exosome products is fundamentally determined by the underlying technology [2] - Natural human-derived exosomes pose risks such as pathogen contamination and batch stability issues, leading to regulatory non-approval in China for cosmetics containing these ingredients [2] - Plant-derived exosomes are milder but lack sufficient compatibility and mechanism research with human cells, focusing mainly on basic repair and antioxidant effects [2] - Artificially synthesized human-like exosomes represent a cutting-edge approach that balances safety and efficacy, as demonstrated by the product "HME" from the brand Guyu, which uses bioengineering techniques to replicate natural exosome structures while eliminating risk factors [2] Group 2: Compliance and Regulation - Compliance is a critical indicator of product safety and legality, with all cosmetic ingredients in China needing to meet regulatory requirements [3] - Guyu's "HME" product complies with the necessary regulations, with all components listed in the "Catalog of Used Cosmetic Ingredients" and its core technology patented, providing strong backing for its compliance and originality [3] Group 3: Brand Credibility and Data Support - A responsible and trustworthy brand will substantiate the safety and efficacy of its products with detailed experimental data [4] - Safety validation should include assessments of immunotoxicity, local irritation, and sensitization [5] - Efficacy validation must be based on cell experiments and human trials, with controlled laboratory environments used to verify the effects on specific skin cells [6][7] - Guyu's "HME" shows a cell migration promotion ability 1.17-1.5 times greater than ordinary human-derived exosomes and a collagen type III production increase of 5-6.7 times [9] - Human efficacy tests indicate a 17.43% average reduction in wrinkle count after 14 days of use, with a further reduction of 26.61% after 28 days [9][10] Group 4: Research Background and Transparency - The research background and transparency of a brand are crucial indicators of its credibility [11] - Brands should have professional research teams and establish deep collaborations with reputable universities or research institutions [12] - Guyu collaborates with Xiamen University to establish a joint research center, enhancing its research credibility [12] - The brand's ability to control the entire production chain, from raw material development to efficacy evaluation, is vital for ensuring product quality and effectiveness [12]

Core Viewpoint - The rise of Gu Yu in the competitive domestic skincare market is attributed to its strategic shift from traditional competition to redefining industry standards through innovative research and development [1] Group 1: Ideological Leadership - Gu Yu's approach marks a transition from "following trends" to "defining standards," moving away from mimicking international brands to creating unique products based on extensive data analysis of nearly 100,000 skin samples from Chinese women [2][3] - The company emphasizes a "component-centric" research logic, focusing on rigorous molecular biology methods to ensure genuine safety and efficacy rather than relying on marketing concepts [2][3] Group 2: Technological Breakthroughs - Gu Yu's technology matrix showcases its disruptive thinking, including extreme purification and precise delivery of traditional plant extracts [5] - The company has developed proprietary technologies such as melt crystallization purification, achieving a purity level of 99% for its star ingredient, Glycyrrhizic acid, significantly enhancing its efficacy and reducing allergy risks [6] - The 28-nanometer encapsulation technology improves transdermal absorption by 3.4 times, while targeted delivery technology allows for precise intervention at the cellular level [6] Group 3: Innovative Production Methods - Gu Yu has shifted from sourcing rare ingredients to producing them through synthetic biology, exemplified by its enzyme biomimetic technology that enables the large-scale production of ginsenoside CK with over 98% purity [7] - This innovation breaks the dependency on natural resources, moving the industry towards a customizable bio-manufacturing era [7] Group 4: Advanced Anti-Aging Solutions - The introduction of human-like exosome HME represents a new standard in anti-aging research, utilizing high-precision biomimetic technology to create a safe and effective product without the risks associated with natural exosomes [8][9] - The AI-driven process enhances the efficiency of component analysis and selection, resulting in an anti-aging product that outperforms natural counterparts [9][11] Group 5: Market Impact and Validation - Gu Yu's ginsenoside CK shows remarkable efficacy, promoting collagen production significantly more than leading competitors, establishing a generational gap in effectiveness [13] - Clinical trials demonstrate that products containing HME reduce wrinkle count by an average of 26.61% after 28 days, providing strong evidence for its anti-aging claims [13] - Collaborations with academic institutions have revealed broader health implications, linking Gu Yu's products to overall anti-aging benefits, thus redefining skincare as a field closely related to biotechnology [13][14]

Core Insights - The article highlights that Gu Yu has established itself as a leading "R&D powerhouse" among domestic brands, emphasizing its commitment to long-term development through substantial R&D investments [1][5]. R&D Investment - Gu Yu has made significant long-term R&D investments, marking a shift from a focus on short-term market hits to a "long-termism" approach, aligning with strategies of top international skincare groups [1]. Technological Barriers - The brand is building its own "technological barriers" by developing exclusive patented ingredients like "human-like exosome HME," transitioning from merely utilizing popular ingredients to creating new ones, which distinguishes it from ordinary domestic brands [1][2]. Strategic Development of Raw Materials - Gu Yu has evolved from focusing on single core ingredients to constructing a systematic "Chinese core raw material library," leveraging proprietary technologies for groundbreaking whitening and anti-aging ingredients [1][2]. Comprehensive Self-Research - The company has adopted a unique "full-stack self-research" model, establishing its own factories for synthetic biology, chemical synthesis, and plant extraction, enhancing its control over core raw materials and ensuring product uniqueness [4]. Future Vision - Collaborating with Xiamen University to establish a "Biomedicine Joint Research Center," led by an academician from the Chinese Academy of Sciences, indicates Gu Yu's ambition to transition from a cosmetics brand to a biotechnology company, showcasing a broader research vision [5]. Conclusion - Gu Yu has solidified its position as a "core player" in the domestic skincare landscape through continuous R&D investment, unique full-industry chain layout, and forward-looking technological breakthroughs, demonstrating that the value of domestic brands extends beyond cost-effectiveness and design to robust, globally competitive R&D capabilities [5].

Core Viewpoint - The company is positioning itself as a "research-driven" brand by focusing on scientific evidence for its product claims and emphasizing foundational research over mere marketing [1][4]. Group 1: Product Development and Innovation - The company emphasizes the importance of understanding not just the ingredients used in products, but also the rationale behind their effectiveness, showcasing its foundational research capabilities [1]. - A breakthrough ingredient, "human-like exosome HME," was introduced at a research conference, highlighting the company's proprietary technology in developing advanced anti-aging solutions [1][3]. Group 2: Safety, Efficacy, and Compliance - The new ingredient is designed with safety in mind, utilizing patented high-precision engineering technology to eliminate risk factors associated with human-derived exosomes [3]. - The efficacy of the ingredient is enhanced through artificial synthesis that mimics human exosome structures, incorporating targeted peptides and gene-level components, resulting in superior anti-aging effects compared to traditional human exosomes [3]. - All components of the new ingredient are compliant with the "Catalog of Used Cosmetic Ingredients" and have received national patent authorization, ensuring regulatory adherence and intellectual property protection [3]. Group 3: Long-term Investment in Research - The company plans to invest 2 billion yuan in research and development over the next decade, supported by established research centers and certified laboratories, ensuring a robust foundation for product reliability [3]. - The company’s integrated model covering "research-production-raw materials" allows for stringent quality control from the raw material stage, enhancing product stability and consistency [3]. Group 4: Evolution of Research Capabilities - The introduction of "human-like exosome HME" signifies the company's advancement into modern biological research, moving beyond plant-based ingredients to cellular and genetic regulation [4].

Core Viewpoint - The competition in anti-aging ingredients has evolved from mere concentration comparisons to a comprehensive battle focusing on targeting, safety, and mechanisms of action. The newly launched "human-like exosome HME" by Gu Yu has garnered attention for its unique cellular gene-level anti-aging mechanism, raising questions about its advantages over traditional ingredients like Bosen and A-Retinol [1][15]. Group 1: Mechanism Comparison - Human-like exosome HME represents a breakthrough in anti-aging ingredients, utilizing proprietary artificial exosome technology to simulate natural human exosomes, which are crucial for cellular communication [1]. - Bosen acts as a conservative anti-aging ingredient, stimulating glycosaminoglycan synthesis and enhancing the extracellular matrix in the dermis [3]. - A-Retinol, a derivative of Vitamin A, promotes skin renewal and collagen synthesis but is known for its strong irritation potential [5]. Group 2: Safety Comparison - Human-like exosome HME ensures safety by eliminating risk factors through high-precision engineering technology, complying with cosmetic ingredient regulations [6][7]. - Bosen may increase skin sensitivity and lead to adverse reactions such as redness and itching with prolonged use [8]. - A-Retinol poses significant safety risks, including skin irritation and phototoxicity, especially at higher concentrations [9]. Group 3: Efficacy and Innovation - Human-like exosome HME is backed by Gu Yu's comprehensive R&D capabilities, including advanced facilities and AI technology to optimize ingredient analysis and formulation [10]. - Bosen's efficacy is concentration-dependent, with noticeable effects typically requiring a minimum of 3% concentration [11][12]. - A-Retinol requires careful usage and gradual acclimatization due to its potential side effects, particularly in certain demographics [13][14]. Group 4: Choosing the Right Anti-Aging Ingredient - Human-like exosome HME is positioned as the future of anti-aging skincare, suitable for consumers seeking effective and safe solutions [15]. - Bosen is recommended for those with mild anti-aging needs, particularly for dry skin types [16]. - A-Retinol is ideal for consumers with resilient skin looking for rapid results, but caution is advised regarding its use [16].

Core Viewpoint - Gu Yu Biotechnology Group officially launched its third innovative raw material, human-like exosome HME, marking a significant shift from marketing-driven to research-driven strategies in the domestic beauty industry [1] Group 1: Exosome and Aging - The essence of skin aging is the inability of the human body to maintain normal cell renewal and homeostasis, leading to the accumulation of aging cells and disrupted cell communication [1] - Exosomes, nano-sized vesicles secreted by cells, play a crucial role in cell communication and have been recognized for their scientific value, receiving four Nobel Prizes in the past two decades [1] Group 2: Industry Challenges - Despite the proven anti-aging and repair functions of exosomes, their application in cosmetics faces obstacles, particularly the risks associated with human-derived exosomes, which are not permitted for direct addition to cosmetics in China [1][2] - Brands have turned to plant-derived exosomes, but these face challenges such as low extraction efficiency, difficulty in large-scale production, and instability [2] Group 3: Gu Yu's Breakthrough - Gu Yu has developed human-like exosome HME using proprietary artificial exosome technology, simulating the structure and active components of human-derived exosomes to create a highly human-like artificial exosome [3] - The technology accurately mimics the phospholipid bilayer structure of natural human-derived exosomes, loading gene-level active ingredients like miRNA and siRNA, achieving multiple anti-aging effects [3] Group 4: Core Advantages of HME - Human-like exosome HME has four core advantages: - Safety: High-precision engineering technology eliminates any human-derived risk factors [4] - Efficacy: The artificial exosome structure enhances cell regeneration capabilities by 1.17-1.5 times compared to human-derived exosomes and promotes type III collagen production by 5-6.7 times [4] - Compliance: All components are listed in the "Catalog of Used Cosmetic Ingredients" or have passed new ingredient filing, fully complying with regulations [4] - Innovation: Compared to commonly used plant exosomes or ordinary liposomes, Gu Yu achieves a high degree of human-like simulation and enhances overall efficacy through precise modifications [4] Group 5: Efficacy Validation - Human efficacy tests show that after 48 hours of using human-like exosome HME, the proportion of aging cells decreased by 41.5%, and cell renewal and repair improved by 60%, demonstrating its outstanding anti-aging efficacy [6] - Gu Yu has proven that Chinese brands can also gain a voice in the upstream core raw material field, emphasizing a return to research-driven approaches as the future of domestic beauty [6]

Core Insights - The article highlights the significant breakthrough of Gu Yu's latest anti-aging innovation, "Human-like Exosome HME," which demonstrates a reduction in wrinkles by 17.43% in 14 days and 26.61% in 28 days, marking a new era in cellular-level anti-aging skincare [1][4]. Group 1: Understanding Exosomes - Exosomes are described as natural nano-sized vesicles in the human body that facilitate communication between cells, playing a crucial role in skin metabolism, repair, and regeneration [2]. - The decline in high-quality exosome quantity with age leads to reduced skin repair capabilities, prompting the question of whether supplementing exosomes can slow the aging process [2]. Group 2: Innovation of Human-like Exosome HME - Gu Yu's Human-like Exosome HME is developed using proprietary artificial exosome technology, which has been patented, showcasing a significant advancement in anti-aging ingredients [3]. - This innovation addresses three core challenges in the industry: safety, efficiency, and industrialization of exosomes [3]. Group 3: Efficacy Data - Experimental results indicate that Human-like Exosome HME enhances cell migration ability by 1.17-1.5 times compared to human-derived exosomes and increases collagen type III production by 5-6.7 times [4]. - The product has shown substantial efficacy in reducing wrinkle count in human trials, with an average reduction of 17.43% after 14 days and 26.61% after 28 days [4]. Group 4: Mechanism of Action - The mechanism of Human-like Exosome HME differs fundamentally from traditional anti-aging ingredients by directly supplementing safe exosomes that release gene-level anti-aging instructions within cells [5]. - The technology achieves three breakthroughs: direct regulation of target genes, precise delivery to key skin cells, and stability at room temperature, addressing industrialization challenges [5]. Group 5: Research and Development Commitment - Gu Yu has established a comprehensive research and development system, including a 45,000 square meter cosmetics manufacturing facility and a total R&D investment exceeding 250 million yuan, with plans for an additional 2 billion yuan over the next decade [6]. - The commitment to R&D positions Gu Yu as a leader in innovation within the domestic beauty industry, transitioning from a follower to a technology pioneer [6].

Core Insights - Gu Yu has launched a new anti-aging ingredient, "Human-like Exosome HME," which is the third core ingredient developed through exclusive patented research, enhancing its competitive edge in the global life and health sector [1][3] - The company aims to establish a complete research and development ecosystem, focusing on original ingredient innovation and addressing the unique skin characteristics of Chinese consumers [1][8] - Gu Yu plans to invest 2 billion yuan in research and development over the next decade, demonstrating its commitment to technological advancement in the competitive beauty market [16] Research and Development Strategy - The newly developed "Human-like Exosome HME" utilizes proprietary artificial exosome technology to create a nanovesicle system that mimics natural human exosomes, delivering key genetic components for anti-aging effects [3][4] - The ingredient has shown significant efficacy in cell migration and collagen production, outperforming natural human exosomes in various tests [7][10] - Gu Yu has established a comprehensive R&D framework, including a 3,000 square meter research center and multiple production facilities, positioning itself as a leader in the industry [10][12] Collaboration and Innovation - The company collaborates with academic institutions, including the establishment of a joint research center with Xiamen University, focusing on the development of bioactive components and anti-aging research [13][14] - Gu Yu's research team consists of over 100 professionals, including 10 senior scientists and 15 PhDs, ensuring a robust talent pool for innovation [13] - The company has successfully developed other core ingredients, such as "Aurora Glycyrrhizin" and "Rare Ginseng Saponin CK," which have achieved high purity and efficacy through advanced biotechnological methods [8][10] Market Positioning - Gu Yu aims to enhance the global competitiveness of Chinese beauty brands by leveraging its proprietary technologies and research capabilities [1][16] - The company emphasizes the importance of safety, efficacy, compliance, and innovation in its product development, ensuring that its ingredients meet market standards [6][7] - With a focus on scientific rigor and consumer needs, Gu Yu is positioned to lead the domestic beauty market and expand its international presence [1][16]