Core Insights - Researchers at Columbia University and Rockefeller University have developed a method using bacteria as "Trojan horses" to bypass the immune system and deliver viruses directly to tumors, marking a significant advancement in cancer treatment [2][3] - This "Trojan horse" system combines the tumor-targeting capabilities of bacteria with the virus's ability to infect and destroy cancer cells, providing a new approach for safe and precise cancer therapy [2] - The technology has been validated in mouse experiments and represents the first example of engineered collaboration between bacteria and oncolytic viruses, laying the groundwork for multi-biological combination therapies [2] Summary by Sections - **Bacterial-Viral Collaboration**: The research team successfully utilized bacteria, specifically Salmonella, to deliver oncolytic viruses to solid tumors, overcoming the challenge posed by the immune system [3] - **Clinical Application Potential**: The latest advancements indicate a significant step towards clinical application, with ongoing tests on various tumor types and the exploration of combining this system with clinically safe bacterial strains [3] - **Oncolytic Virus Therapy**: Oncolytic virus therapy, which uses naturally occurring or genetically modified viruses to specifically target and destroy cancer cells, shows strong potential, particularly in brain tumors, but faces challenges from the body's immune defenses [2]