Core Insights - Ovarian aging is a significant process affecting women's overall health, leading to accelerated bodily decline and chronic diseases [2][6] - Recent advancements in regenerative medicine, particularly with placental peptides, offer new strategies to delay ovarian aging at the cellular level [1][9] Group 1: Ovarian Aging and Its Implications - Ovarian aging is not as visibly apparent as skin aging but has profound effects on bodily functions and can lead to chronic diseases [2] - Research indicates that aging ovarian cells exhibit increased senescence signaling pathways, with specific markers like CDKN1A/p21 showing elevated expression in older populations [5][6] Group 2: Regenerative Medicine and Interventions - The modern aesthetic medicine industry is shifting its focus from external modifications to internal nourishment, utilizing placental peptides to activate cellular self-healing and enhance ovarian health [7][9] - Placental peptides contain over 400 active cell factors that nourish ovarian cells, regulate the AKT signaling pathway, and improve hormonal balance, potentially restoring ovarian function to a youthful state [9] Group 3: Research Findings and Future Directions - Researchers have categorized ovarian granulosa cells into three subtypes based on their spatial distribution, indicating a shift in functional characteristics during ovarian aging [8] - The introduction of placental peptides as a NMPA-approved intravenous product marks a significant advancement in the field, offering a more effective delivery method with nearly 100% bioavailability [9]