Core Viewpoint - The research indicates that oral administration of clinical safe doses of Vitamin C can significantly delay ovarian aging in primates, revealing its protective mechanism through the activation of the NRF2 signaling pathway [2][4][5]. Group 1: Research Background - Ovarian aging plays a critical role in women's reproductive health, impacting treatment strategies and quality of life [3]. - Previous studies by Liu Guanghui's team have established that Vitamin C can delay cellular aging and has been linked to a significant decline in antioxidant capacity during ovarian aging in primates [3]. Group 2: Key Findings - A 3.3-year intervention study on middle-aged crab-eating macaques demonstrated that oral Vitamin C can reduce key aging biomarkers, including oxidative stress and follicle depletion [4]. - The study constructed a primate ovarian single-cell transcriptome aging clock, showing that Vitamin C can make oocyte biological age younger by an average of 1.35 years and somatic cell biological age younger by 5.66 years, particularly in granulosa, endothelial, and stromal cells [4]. - Vitamin C effectively reverses aging and inflammation-related phenotypes in endothelial cells, making their biological age nearly 7 years younger [4]. Group 3: Mechanism of Action - The effect of Vitamin C in delaying ovarian aging is partially mediated through the NRF2 pathway, which plays multiple protective roles in human ovarian cells, including delaying aging, inhibiting inflammation, maintaining chromatin stability, and enhancing mitochondrial function [5]. Group 4: Implications - This research validates the concept of using a single compound to delay ovarian aging in primate models and highlights the potential of Vitamin C in developing interventions for human ovarian aging [8].

Core Viewpoint - The article discusses the significance of ovarian aging, its implications on female fertility, and highlights a recent study that identifies NCOA7 as a potential target for mitigating ovarian aging and improving reproductive health [2][3][10]. Group 1: Ovarian Aging and Its Implications - Ovarian aging is one of the earliest forms of aging in the human body, leading to a decline in oocyte quantity and quality, which increases the risks of infertility, miscarriage, pregnancy complications, and birth defects [2]. - Factors such as genetic predisposition, autoimmune conditions, medical interventions, and environmental stimuli can accelerate ovarian aging, resulting in premature ovarian insufficiency (POI) [2]. - The global trend of delayed childbirth and extended post-menopausal lifespan underscores the urgent need for interventions to alleviate ovarian aging and enhance quality of life [3]. Group 2: Recent Research Findings - A study published in Nature Aging reveals that NCOA7 plays a crucial role in regulating ovarian aging by mediating the autophagic clearance of stress granules (SG), which are formed under oxidative stress [3][6]. - The research indicates that harmful mutations and reduced expression of NCOA7 are associated with ovarian aging in both physiological and pathological contexts, leading to accelerated cellular aging and decreased fertility in mice [6][8]. - The study suggests that enhancing the autophagic degradation of stress granules through NCOA7 mRNA delivery or rapamycin can mitigate ovarian aging and improve reproductive capacity [8][10].

Core Insights - Ovarian aging is a significant process affecting women's overall health, leading to accelerated bodily decline and chronic diseases [2][6] - Recent advancements in regenerative medicine, particularly with placental peptides, offer new strategies to delay ovarian aging at the cellular level [1][9] Group 1: Ovarian Aging and Its Implications - Ovarian aging is not as visibly apparent as skin aging but has profound effects on bodily functions and can lead to chronic diseases [2] - Research indicates that aging ovarian cells exhibit increased senescence signaling pathways, with specific markers like CDKN1A/p21 showing elevated expression in older populations [5][6] Group 2: Regenerative Medicine and Interventions - The modern aesthetic medicine industry is shifting its focus from external modifications to internal nourishment, utilizing placental peptides to activate cellular self-healing and enhance ovarian health [7][9] - Placental peptides contain over 400 active cell factors that nourish ovarian cells, regulate the AKT signaling pathway, and improve hormonal balance, potentially restoring ovarian function to a youthful state [9] Group 3: Research Findings and Future Directions - Researchers have categorized ovarian granulosa cells into three subtypes based on their spatial distribution, indicating a shift in functional characteristics during ovarian aging [8] - The introduction of placental peptides as a NMPA-approved intravenous product marks a significant advancement in the field, offering a more effective delivery method with nearly 100% bioavailability [9]