Core Viewpoint - The Chinese Academy of Agricultural Sciences, in collaboration with domestic universities, has identified a key "susceptibility switch" gene related to wheat fusarium head blight, leading to the development of new wheat materials that are resistant to both fusarium head blight and powdery mildew without affecting growth and yield [1]. Group 1: Research Findings - The research team identified the key gene TaROD1 in wheat, which, when knocked out, significantly enhances resistance to fusarium head blight and also improves resistance to powdery mildew [1]. - The study highlights the urgent need to discover new regulatory genes for fusarium head blight resistance, as there are currently only two main effective resistance loci cloned [1]. Group 2: Agricultural Implications - The newly developed mutant wheat lines show no significant differences in key agronomic traits such as plant height, spike characteristics, and single-plant yield compared to the wild type, achieving disease resistance without yield loss [1]. - The research results provide important genetic resources and technical pathways for improving disease resistance in wheat [1].