Core Viewpoint - The study highlights that cohabitation can reshape gut microbiota, specifically increasing the presence of Rikenella microfusus, which mitigates acute liver injury (ALI) and provides new scientific evidence for the prevention and treatment of ALI [2][3][5]. Group 1: Research Findings - Cohabitation leads to an increase in Rikenella microfusus, which reduces the severity of acute liver injury [5][7]. - Rikenella microfusus secretes β-galactosidase, enhancing the absorption of dietary isoflavone Bio-A, which plays a crucial role in liver protection [4][5]. - Bio-A interacts with pyruvate carboxylase (PC) and propionyl-CoA carboxylase α subunit (PCCA), boosting the tricarboxylic acid cycle and promoting the synthesis of protective glutathione in liver cells [4][5]. Group 2: Implications - The findings underscore the impact of microbiome composition on acute liver injury and the ability of isoflavone absorption to alleviate the severity of ALI [7]. - The research suggests a new connection between social behavior and health, indicating that regulating gut microbiota or supplementing specific metabolites could be a novel strategy for preventing and treating acute liver injury [7].