Core Viewpoint - Targeting age-related LINE-1 activation can alleviate cardiac aging, highlighting its potential as a therapeutic target for age-related cardiac dysfunction [4]. Group 1: Research Findings - The study indicates that the expression of LINE-1 in the heart increases with age [7]. - Researchers created heart-specific Mov10 gene knockout mice, which could not suppress LINE-1 expression, leading to LINE-1 de-repression, cardiac dysfunction, and early cardiac aging by three months of age [7]. - Activation of the cGAS-STING pathway was observed in these knockout mice, suggesting a link between LINE-1 and cardiac aging [7]. Group 2: Therapeutic Implications - The use of Lamivudine (3TC), a reverse transcriptase inhibitor, and H-151, which inhibits STING, both suppressed cGAS-STING activation and alleviated aging in new muscle cells from Mov10 knockout mice [7]. - Both inhibitors improved cardiac function in naturally aged mice and reduced cardiac inflammation and aging phenotypes [7]. - These findings suggest that LINE-1 and its downstream effectors could be potential targets for treating age-related cardiac dysfunction [7].

Core Insights - Greenland sharks exhibit signs of cardiac aging at a young age but maintain heart function, indicating an evolutionary adaptation to chronic oxidative damage [1][2] Group 1: Research Findings - Researchers analyzed heart samples from six Greenland sharks aged between 100 to 150 years, revealing significant fibrosis and accumulation of oxidative damage markers, specifically lipofuscin and 3-nitrotyrosine [1] - Despite the presence of these aging markers, the sharks were in good health and showed no abnormalities in physiological function, suggesting robust myocardial cell vitality [1] Group 2: Implications - The ability of Greenland sharks to withstand chronic oxidative damage without a decline in heart function may be crucial for their exceptional longevity, providing new insights for improving heart health in the elderly [2]

编辑丨王多鱼 排版丨水成文 心脏 是人体循环系统的核心动力器官，其结构和功能的完整性对于生命和健康的维系至关重要。根据世界 卫生组织和全球健康研究数据，心血管疾病长期以来一直是人类健康的"头号杀手"。随着年龄增长，心脏逐 渐出现结构重塑、收缩与舒张功能减退以及心肌纤维化等衰老特征，显著增加了冠心病、心力衰竭、心律 失常等心脏疾病的风险，并且常常与高血压、动脉粥样硬化等疾病交织存在，进一步加重疾病负担。 然而，当前针对心脏衰老的干预手段非常有限。深入解析心脏衰老的分子机制，对于开发延缓心脏功能退 化、预防老年相关心血管疾病的新策略具有极为重要的科研意义和临床应用价值。 2025 年 4 月 29 日，国家生物信息中心 张维绮 团队联合中国科学院动物研究所 曲静 、 刘光慧 团队，首都 医科大学附属北京安贞医院 姚艳 团队，在 Nature 子刊 Nature Cardiovascular Research 上 发表了题为： ARID5A Orchestrates Cardiac Aging and Inflammation through MAVS mRNA Stabilization 的研究论文。 该研究利用 ...