Core Insights - A compound called indole-3-carbinol found in cruciferous vegetables enhances the efficacy of immunotherapy by restoring the function of cytotoxic T lymphocytes [1][2] - The study published in Nature Communications indicates that a diet containing indole-3-carbinol significantly improves the response rate to cancer treatment [1] Group 1: Research Findings - Indole-3-carbinol is abundant in vegetables like cabbage and broccoli, and its presence in the diet led to a 50% to 60% effectiveness rate in cancer treatment among animals [1] - When the diet was devoid of indole-3-carbinol, the effectiveness rate dropped to 20% [1] - The research highlights the role of indole-3-carbinol in activating cytotoxic T lymphocytes, which are crucial for targeting and eliminating tumor cells [1][2] Group 2: Mechanism of Action - Indole-3-carbinol binds to a transcription factor known as the "aryl hydrocarbon receptor," which is more prominently expressed in cytotoxic T lymphocytes [2] - In the absence of indole-3-carbinol, cytotoxic T lymphocytes fail to respond to immunotherapy [2] - The findings suggest that dietary components can play a significant role in enhancing anti-tumor immune responses, potentially guiding dietary recommendations for patients undergoing treatment [2]