Core Insights - A compound called indole-3-carbinol found in cruciferous vegetables enhances the efficacy of immunotherapy by restoring the function of cytotoxic T lymphocytes [1][2] - The study published in Nature Communications indicates that a diet containing indole-3-carbinol significantly improves the response rate to cancer treatment [1] Group 1: Research Findings - Indole-3-carbinol is abundant in vegetables like cabbage and broccoli, and its presence in the diet led to a 50% to 60% effectiveness rate in cancer treatment among animals [1] - When the diet was devoid of indole-3-carbinol, the effectiveness rate dropped to 20% [1] - The research highlights the role of indole-3-carbinol in activating cytotoxic T lymphocytes, which are crucial for targeting and eliminating tumor cells [1][2] Group 2: Mechanism of Action - Indole-3-carbinol binds to a transcription factor known as the "aryl hydrocarbon receptor," which is more prominently expressed in cytotoxic T lymphocytes [2] - In the absence of indole-3-carbinol, cytotoxic T lymphocytes fail to respond to immunotherapy [2] - The findings suggest that dietary components can play a significant role in enhancing anti-tumor immune responses, potentially guiding dietary recommendations for patients undergoing treatment [2]

撰文丨王聪 编辑丨王多鱼 排版丨水成文 癌症转移，包括肿瘤细胞在远端器官的迁移、侵袭和定植，是癌症患者死亡的主要原因。癌症转移的一个关键步骤是肿瘤细胞在远端器官的植入，这 常常受到宿主免疫系统的挑战。CD8 + T 细胞在免疫反应中发挥着关键作用，充当哨兵来识别并清除肿瘤细胞。然而，使 CD8 + T 细胞能够满足有 效抗肿瘤反应的代谢需求，尚未完全明了。 近日，广州大学 王雄军 、江南大学 冯宁翰 、同济大学附属同济医院 于观贞 团队合作，在 Cell 子刊 Cell Metabolism 上发表了题为： Xylulose 5-phosphate Fosters Sustained Antitumor Activity of Progenitor-like Exhausted SLC35E2 + CD8 + T Effector Cells 的研究论文，该论文被选 为 封面论文 。 该研究表明，代谢物 木酮糖 5-磷酸 （Xu5P） 促进 SLC35E2 + CD8 + 耗竭前体 T 细胞的持续抗肿瘤活性。而补充 Xu5P 或摄入富含 Xu5P 的饮 食 （例如苦瓜，百合等蔬菜） 能够 与抗 PD-1 疗法 ...