格隆汇12月29日丨奥赛康(002755.SZ)公布，子公司江苏奥赛康药业有限公司（简称"奥赛康药业"）与杭 州阿诺生物医药科技有限公司（简称"阿诺医药"）达成许可引进协议。根据协议，奥赛康药业将获得阿 诺医药在研的1类创新药AN9025项目在许可区域内的开发、生产及商业化的独占权益。在协议生效后的 10个工作日内，奥赛康药业将向阿诺医药支付3500万元人民币的一次性、不可退还、不可抵扣的首付 款。奥赛康药业将向阿诺医药支付与产品研发、注册及上市相关的各阶段开发里程碑付款，总计不超过 4.7亿元人民币。奥赛康药业将向阿诺医药支付与若干销售里程碑事件达成相关的付款，总计不超过 11.28亿元人民币。 奥赛康药业围绕肿瘤治疗领域，通过自主研发与战略合作，搭建起丰富且具有潜力的研发管线。本次引 进的创新药AN9025项目是一款泛RAS抑制剂，可用于肺癌及结直肠癌、胰腺癌等肿瘤的治疗，有望进 一步强化公司在肺癌、消化道肿瘤等优势治疗领域的布局，与公司现有临床资源和商业化资源形成协同 效应。AN9025的引进将进一步丰富公司创新药产品管线，提升公司在抗肿瘤治疗领域的竞争力，对公 司的战略布局起到积极作用。 AN9025 ...

Core Viewpoint - Aosaikang Pharmaceutical has entered into a licensing agreement with Hangzhou Anuo Biopharmaceutical Technology, acquiring exclusive rights for the development, production, and commercialization of the innovative drug AN9025, a pan-RAS inhibitor targeting RAS mutation-related solid tumors [1][2] Group 1: Financial Terms of the Agreement - Aosaikang Pharmaceutical will pay a non-refundable upfront fee of 35 million RMB within 10 working days after the agreement takes effect [1] - Total milestone payments related to product development, registration, and market launch will not exceed 470 million RMB [1] - Additional payments related to sales milestones will not exceed 1.128 billion RMB [1] Group 2: Product Details and Clinical Development - AN9025 is a novel oral pan-RAS inhibitor that effectively targets KRAS, NRAS, and HRAS mutations by forming a ternary complex with activated RAS-GTP and molecular chaperone [1] - The drug is intended for the treatment of RAS mutation-related solid tumors and has received clinical trial approval from the FDA in the United States [1] Group 3: Strategic Implications for Aosaikang - The introduction of AN9025 enhances Aosaikang's pipeline in oncology, particularly in lung cancer, colorectal cancer, and pancreatic cancer, reinforcing its competitive position in these therapeutic areas [2] - The collaboration is expected to create synergies with the company's existing clinical and commercialization resources, positively impacting its strategic layout in the oncology sector [2]