Core Insights - The recent rise in COVID-19 cases has drawn public attention, particularly following the announcement of singer Eason Chan's infection, indicating a potential resurgence of the virus in the population [1][2]. Summary by Sections COVID-19 Case Trends - In March 2025, a total of 56,286 new confirmed COVID-19 cases were reported across 31 provinces, with 131 severe cases and 7 deaths attributed to underlying health conditions combined with COVID-19 [2]. - The positivity rate for COVID-19 among influenza-like illness cases increased from 3.5% in the 10th week of 2025 to 6.3% by the end of March [2]. Variants and Mutations - The dominant COVID-19 variants in China have undergone multiple changes over the past two and a half years, transitioning from BA.5.2 and BF.7 to XDV and its sub-variants [1][3]. - The emergence of new variants with immune evasion capabilities has contributed to the re-infection of individuals and the occurrence of new infection peaks [3][4]. Seasonal Patterns and Infection Dynamics - Unlike typical respiratory viruses that peak in winter and spring, COVID-19 has shown a tendency to have peaks in summer as well, suggesting that its spread is more influenced by variant mutations and population immunity rather than seasonal changes [4][5]. - The current dominant variant, XDV and its sub-variant NB.1.8.1, has shown significant transmission advantages, affecting not only mainland China but also regions like Hong Kong, Macau, Japan, and South Korea [6]. Symptoms and Severity - The currently circulating variants have not shown new symptoms; common symptoms remain fever, sore throat, cough, and muscle pain, with a low proportion of severe cases overall [5][6].